DIF-3

Product Name: DIF-3
CAS No.: 113411-17-9
Chemical Name: DIF-3
Synonyms: DIF-3, 10 mM in DMSO;DIF-3 >=99% (HPLC), solid;1-(3-Chloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one;1-Hexanone, 1-(3-chloro-2,6-dihydroxy-4-methoxyphenyl)-;1-(3-Chloro-2,6-dihydroxy-4-methoxyphenyl)-1-hexanone, Differentiation-inducing factor 3
CBNumber: CB4498007
Molecular Formula: C13H17ClO4
Formula Weight: 272.72
MOL File: 113411-17-9.mol

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DIF-3 Property

Boiling point:: 416.9±45.0 °C(Predicted)
Density: 1.240±0.06 g/cm3(Predicted)
solubility: DMSO: 46 mg/mL, soluble
form: solid
pka: 5.92±0.45(Predicted)
color: White to off-white

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: D0567
Product name: DIF-3
Purity: ≥99% (HPLC), solid
Packaging: 1mg
Price: $135
Updated: 2025/07/31

AK Scientific

Product number: 0324AQ
Product name: DIF-3
Packaging: 1mg
Price: $188
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: MTB0000064
Product name: DIF-3
Purity: 95.00%
Packaging: 1MG
Price: $554.23
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: MTB0000064
Product name: DIF-3
Purity: 95.00%
Packaging: 25MG
Price: $1298.86
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: MTB0000064
Product name: DIF-3
Purity: 95.00%
Packaging: 50MG
Price: $1593.9
Updated: 2021/12/16

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DIF-3 Chemical Properties,Usage,Production

Uses

DIF-3 has been used: as a glycogen synthase kinase-3β (GSK-3β) activator to determine if GSK-3β is required for the anti-inflammatory actions of VU0360172 (VuPAM) in murine microglia, as a phosphorylation inhibitor for GSK-3β to examine the links between activation of protein kinase B (PKB)/GSK-3β/Fyn axis and nuclear factor erythroid 2–related factor 2 (NRF2) retention, as a GSK3β activator to study its effects on the cyclooxygenase 2 (COX2) expression levels in human primary chondrocytes in response to visfatin, as a GSK3β activator to study its effects on the intracellular mechanics along with F-actin and β-tubulin fiber networks in human primary chondrocytes

Biological Activity

Differentiation-inducing factor-3 (DIF-3) prevents the proliferation of intestinal cancer cells in vitro and in vivo. It may serve as a novel anti-cancer agent.', 'DIF-3 Inhibits cell cycle by inducing G0/G1 arrest.

in vivo

DIF-3 (150 mg/kg; p.o.; once a day for 5 days/week over 4 weeks) inhibits oxidative stress (0.2% KBrO₃)-induced tumors in Mutyh^-/- mice^[1].

Animal Model:	Mutyh^-/- mice (KBrO3 dissolved in water at a concentration of 2 g/L was administered to 4-week-old mice for 12 weeks)^[1]
Dosage:	150 mg/kg
Administration:	Oral gavage (p.o.); once a day for 5 days/week over 4 weeks
Result:	Markedly reduced the number of intestinal tumors, especially the number of large tumors with a diameter of >2.0 mm. No differences in the appearance, activity, body weight, or blood cell counts. The numbers of TCF7L2-and cyclin D1-positive nuclei in tumors were significantly decreased.

DIF-3 Preparation Products And Raw materials

Raw materials

Preparation Products

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DIF-3 Suppliers

China 18 Switzerland 1 United States 4 Global 23

Shanghai Beckham Medical Technology Co., Ltd

Tel: 13816613772
Fax: QQ: 12922499
Email: huahero21@sina.com
Country: China
ProdList: 2391
Advantage: 55

Shandong Ono Chemical Co., Ltd.

Tel: 0539-6362799 20）
Fax: 0539-6362799（To 20）
Country: China
ProdList: 9998
Advantage: 58

TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Country: United States
ProdList: 32435
Advantage: 58

Energy Chemical

Tel: 021-58432009 400-005-6266
Fax: 021-58436166
Email: marketing1@energy-chemical.com
Country: China
ProdList: 44894
Advantage: 58

Jinan Jiuli Biotechnology Co. , Ltd.

Tel: 15865264761
Email: 486064515@qq.com
Country: China
ProdList: 4810
Advantage: 58

Zhengzhou convergence chemical co., LTD

Tel: 0371-0371-55153829 18003835034
Email: 2853979819@qq.com
Country: China
ProdList: 9998
Advantage: 58

Bide Pharmatech Ltd.

Tel: 400-1647117 13681763483
Email: product02@bidepharm.com
Country: China
ProdList: 59936
Advantage: 58

TargetMol Chemicals Inc.

Tel: 4008200310
Email: marketing@tsbiochem.com
Country: China
ProdList: 24961
Advantage: 58

Nantong QuanYi Biotechnology Co., Ltd

Tel: 0513-66337626 18051384581
Email: sales@chemhifuture.com
Country: China
ProdList: 5929
Advantage: 58

Shanghai Yifei Biotechnology Co. , Ltd.

Tel: 021-65675885 18964387627
Email: customer_service@efebio.com
Country: China
ProdList: 11973
Advantage: 58

113411-17-9, DIF-3Related Search:

LABOTEST-BB LT00244818 (+)-Griseofulvin 1-((3,5-dichloro)-2,6-dihydroxy-4-methoxyphenyl)-1-hexanone DIF-3

1-(3-Chloro-2,6-dihydroxy-4-methoxyphenyl)-1-hexanone, Differentiation-inducing factor 3

1-Hexanone, 1-(3-chloro-2,6-dihydroxy-4-methoxyphenyl)-

DIF-3 >=99% (HPLC), solid

1-(3-Chloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one

DIF-3, 10 mM in DMSO

113411-17-9

Bioactive Small Molecules

Building Blocks

C13 to C14

Carbonyl Compounds

Cell Biology

Chemical Synthesis

D-DIF

Ketones

Organic Building Blocks