1-((3,5-dichloro)-2,6-dihydroxy-4-methoxyphenyl)-1-hexanone
- Product Name
- 1-((3,5-dichloro)-2,6-dihydroxy-4-methoxyphenyl)-1-hexanone
- CAS No.
- 111050-72-7
- Chemical Name
- 1-((3,5-dichloro)-2,6-dihydroxy-4-methoxyphenyl)-1-hexanone
- Synonyms
- DIF-1, cell proliferation inhibitor;1-(3,5-Chloro-2,6-dihydroxy-4-methoxyphenyl)-1-Hexanone;1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one;1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexane-1-one;1-Hexanone, 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)-;1-((3,5-dichloro)-2,6-dihydroxy-4-methoxyphenyl)-1-hexanone
- CBNumber
- CB31394912
- Molecular Formula
- C13H16Cl2O4
- Formula Weight
- 307.17
- MOL File
- 111050-72-7.mol
1-((3,5-dichloro)-2,6-dihydroxy-4-methoxyphenyl)-1-hexanone Property
- storage temp.
- 2-8°C
- solubility
- DMSO: soluble20mg/mL, clear
- form
- powder
- color
- white to beige
Safety
- WGK Germany
- 3
N-Bromosuccinimide Price
- Product number
- SML0599
- Product name
- DIF-1
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $128
- Updated
- 2024/03/01
- Product number
- SML0599
- Product name
- DIF-1
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $397
- Updated
- 2024/03/01
- Product number
- D445358
- Product name
- DIF-1
- Packaging
- 100μg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- HCH0123233
- Product name
- 1-((3,5-DICHLORO)-2,6-DIHYDROXY-4-METHOXYPHENYL)-1-HEXANONE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $503.02
- Updated
- 2021/12/16
1-((3,5-dichloro)-2,6-dihydroxy-4-methoxyphenyl)-1-hexanone Chemical Properties,Usage,Production
Uses
DIF-1 is a cell growth suppressor that promotes differentiation in HL-60 cells.
Definition
ChEBI: A differentiation-inducing factor that is hexaphenone bearing two chloro substituents at positions 3 and 5, two hydroxy substituents at positions 2 and 6 as well as a single methoxy substituent at position 4. A secreted, chlorinated molecule that controls ell fate during development of Dictyostelium cells.
Biological Activity
DIF-1 (differentiation-inducing factor-1) is isolated from a Dictyostelium slime mold, and is used to inhibit proliferation/promote differentiation in various cell lines.', 'DIF-1 is a cell differentiation inducing factor.
Differentiation-inducing factor-1 (DIF-1) blocks the migration and invasion of cells and decreases the expression of matrix metalloproteinase-2. It prevents the proliferation of cells using glycogen synthase kinase-3 (GSK-3)-dependent mechanism. DIF-1 is more active when compared to DIF-2 in promoting stalk cell differentiation under submerged assay conditions.
1-((3,5-dichloro)-2,6-dihydroxy-4-methoxyphenyl)-1-hexanone Preparation Products And Raw materials
Raw materials
Preparation Products
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