Sobuzoxane Property

Melting point:

128-130°; mp 132-133° (Cai, 1989)

Boiling point:

664.9±55.0 °C(Predicted)

Density 

1.272±0.06 g/cm3(Predicted)

solubility 

DMSO: 19 mg/mL

form 

solid

pka

2.75±0.20(Predicted)

Safety

WGK Germany 

2

RTECS 

FG1582500

Toxicity

LD50 in male, female mice, rats (mg/kg): 807, 960, 877, 567 i.p.; 400, 673, 3025, 2821 s.c.; >5 g/kg orally in all species (Tokiwa)

Hazard and Precautionary Statements (GHS)

Sobuzoxane Chemical Properties,Usage,Production

Description

Sobuzoxane, a novel bis(2,6-dioxopiperazine) derivative, was introduced in Japan for the treatment of malignant lymphoma and adult T-cell IeukemiaQmphoma (ATLL), which is resistant to chemotherapy and has a poor prognosis. Sobuzoxane exhibits 8 broad spectrum of antitumor activity. It is a noncleavable complexstabilizing topoisomerase II inhibitor and exerts its function via interfering with the catalytic activity of the enzyme to result in an irreversible inhibition of cell division by blockade of chromosome condensation and segregation. Due to Its unique mode of cytocidai activity, it has no cross resistance with many currently available anticancer agents. Sobuzoxane is reported to significantly inhibit growth of human colon, lung, gastric, and breast cancers and is in clinical trials for these indications.

Originator

Zenyaku Kogyo (Japan)

Uses

Sobuzoxane is an inhibitor of DNA topoisomerase II which induces apoptosis.

Definition

ChEBI: Sobuzoxane is an organic molecular entity.

brand name

Perazolln