ChemicalBook > CAS DataBase List > Methyl 5-amino-1H-1,2,4-triazole-3-carboxylate

Methyl 5-amino-1H-1,2,4-triazole-3-carboxylate

Product Name: Methyl 5-amino-1H-1,2,4-triazole-3-carboxylate
CAS No.: 3641-14-3
Chemical Name: Methyl 5-amino-1H-1,2,4-triazole-3-carboxylate
Synonyms: Asciminib Impurity 21;5-AMINO-1H-1 2 4-TRIAZOLE-3-CARBOXYLIC;3-Amino-5-(methoxycarbonyl)-1,2,4-triazole;Methyl 5-aMino-1,2,4-triazole-3-carboxylate;Methyl 3-aMino-1,2,4-triazole-5-carboxylate;ethyl 5-aMino-1H-1,2,4-triazole-3-carboxylate;Methyl 5-amino-1H-1,2,4-triazole-3-carboxylate;Methyl 5-aMino-2H-1,2,4-triazole-3-carboxylate;methyl 3-azanyl-1H-1,2,4-triazole-5-carboxylate;2,4-triazole-3-carboxylicacid,5-amino-1h-methylester
CBNumber: CB4498603
Molecular Formula: C4H6N4O2
Formula Weight: 142.12
MOL File: 3641-14-3.mol

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Methyl 5-amino-1H-1,2,4-triazole-3-carboxylate Property

Melting point:: 218-222 °C (lit.)
Boiling point:: 379.0±25.0 °C(Predicted)
Density: 1.505±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
pka: 8.92±0.40(Predicted)
form: Crystalline Powder
color: White
InChI: InChI=1S/C4H6N4O2/c1-10-3(9)2-6-4(5)8-7-2/h1H3,(H3,5,6,7,8)
InChIKey: MGRNUMFYRVKLEO-UHFFFAOYSA-N
SMILES: N1C(N)=NC(C(OC)=O)=N1
CAS DataBase Reference: 3641-14-3(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 43
Safety Statements: 36/37
WGK Germany: 3
HazardClass: IRRITANT

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning
Hazard statements: H317May cause an allergic skin reaction
Precautionary statements: P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 573787
Product name: 5-Amino-1H-[1,2,4]-triazole-3-carboxylic acid methyl ester
Purity: 96%
Packaging: 1g
Price: $47.18
Updated: 2025/07/31

TRC

Product number: M328680
Product name: Methyl5-amino-1h-1,2,4-triazole-3-carboxylate
Packaging: 500mg
Price: $65
Updated: 2021/12/16

Usbiological

Product number: 455626
Product name: Methyl 5-amino-1h-1,2,4-triazole-3-carboxylate
Packaging: 100mg
Price: $305
Updated: 2021/12/16

TRC

Product number: M328680
Product name: Methyl5-amino-1h-1,2,4-triazole-3-carboxylate
Packaging: 100mg
Price: $45
Updated: 2021/12/16

Matrix Scientific

Product number: 073914
Product name: Methyl 5-amino-4H-[1,2,4]triazole-3-carboxylate
Purity: 95+%
Packaging: 1g
Price: $278
Updated: 2021/12/16

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Methyl 5-amino-1H-1,2,4-triazole-3-carboxylate Chemical Properties,Usage,Production

Synthesis

67-56-1

3641-13-2

3641-14-3

To a solution of 5-amino-1H-1,2,4-triazole-3-carboxylic acid (3.9 g, 30.45 mmol) in methanol (100 mL) was slowly added thionyl chloride (SOCl2, 12 g, 100.84 mmol). The reaction mixture was stirred at 70 °C for 48 hours. Upon completion of the reaction, the mixture was concentrated under reduced pressure to remove the solvent. The residue was dissolved in water (100 mL) and the pH was adjusted with saturated sodium bicarbonate (NaHCO3) solution to 8. Subsequently, the aqueous phase was extracted with dichloromethane (3 x 50 mL). The organic layers were combined, dried with anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to afford methyl 5-amino-1H-1,2,4-triazole-3-carboxylate as a white solid (800 mg, 65% yield). The product was confirmed by LC/MS (ES, m/z): [M + H]+ 143.0. 1H NMR (300 MHz, DMSO-d6): δ 3.85 (s, 3H).

References

[1] Chemical and Pharmaceutical Bulletin, 2004, vol. 52, # 2, p. 192 - 198
[2] Russian Journal of Applied Chemistry, 2006, vol. 79, # 5, p. 783 - 786
[3] Patent: WO2014/66743, 2014, A1. Location in patent: Paragraph 0146

Methyl 5-amino-1H-1,2,4-triazole-3-carboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Methyl 5-amino-1H-1,2,4-triazole-3-carboxylate manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: Methyl 5-amino-1H-1,2,4-triazole-3-carboxylate 3641-14-3
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20t
Release date: 2024-07-15

Zhuozhou Wenxi import and Export Co., Ltd

Product: Methyl 5-amino-1H-1,2,4-triazole-3-carboxylate 3641-14-3
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-11

3641-14-3, Methyl 5-amino-1H-1,2,4-triazole-3-carboxylateRelated Search:

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5-Amino-1H-[1,2,4]-triazole-3-carboxylic acid methyl ester 96%

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5-Amino-1H-[1, 2, 4]-triazole-3-carboxylic acid methyleester

2,4-triazole-3-carboxylicacid,5-amino-1h-methylester

5-AMINO-1H-1 2 4-TRIAZOLE-3-CARBOXYLIC

Methyl 5-amino-1H-1,2,4-triazole-3-carboxylate

3-Amino-5-(methoxycarbonyl)-1,2,4-triazole

1H-5-Amino-1,2,4-trazole-3-caboxylic acid methyl ester

5-Amino-1h-1,2,4-Triazole-3-Carboxylic Acid Methyl Ester Sulfate

methyl 5-amino-1H-1,2,4-triazole-3-carboxylate hydrochloride

1H-1,2,4-triazole-3-carboxylic acid, 5-amino-, methyl este

methyl 5-amino-1H-1,2,4-triazole-3-carboxylate nitrate

3-amino-1H-1,2,4-triazole-5-carboxylic acid methyl ester

methyl 3-azanyl-1H-1,2,4-triazole-5-carboxylate

Methyl 5-aMino-2H-1,2,4-triazole-3-carboxylate

ethyl 5-aMino-1H-1,2,4-triazole-3-carboxylate

Asciminib Impurity 21

5-Amino-1<i>H</i>-[1,2,4]-triazole-3-carboxylic acid methyl ester

3641-14-3

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