ChemicalBook > CAS DataBase List > CLOTRIMAZOLE IMP. A (PHARMEUROPA): (2-CHLOROPHENYL)DIPHENYLMETHANOL

CLOTRIMAZOLE IMP. A (PHARMEUROPA): (2-CHLOROPHENYL)DIPHENYLMETHANOL

Product Name: CLOTRIMAZOLE IMP. A (PHARMEUROPA): (2-CHLOROPHENYL)DIPHENYLMETHANOL
CAS No.: 66774-02-5
Chemical Name: CLOTRIMAZOLE IMP. A (PHARMEUROPA): (2-CHLOROPHENYL)DIPHENYLMETHANOL
Synonyms: TRAM 3;MDK-4025;NSC 170882;MDK 4025,MDK4025;2-Chlorotrityl alcohol;ClotriMazole IMpurity A;o-chlorotriphenylmethanol;Clotrimazole EP Impurity A;ClotriMazole Related CoMpound A;2-CHLOROPHENYL DIPHENYL METHANOL
CBNumber: CB4500669
Molecular Formula: C19H15ClO
Formula Weight: 294.77
MOL File: 66774-02-5.mol

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CLOTRIMAZOLE IMP. A (PHARMEUROPA): (2-CHLOROPHENYL)DIPHENYLMETHANOL Property

Melting point:: 91-92 °C(Solv: acetic acid (64-19-7))
Boiling point:: 144-146 °C(Press: 0.01 Torr)
Density: 1.216±0.06 g/cm3(Predicted)
storage temp.: Refrigerator
solubility: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
form: Solid
pka: 12.36±0.29(Predicted)
color: White to Pale Yellow
InChI: InChI=1S/C19H15ClO/c20-18-14-8-7-13-17(18)19(21,15-9-3-1-4-10-15)16-11-5-2-6-12-16/h1-14,21H
InChIKey: KTVAHLGKTSPDOG-UHFFFAOYSA-N
SMILES: C(O)(C1=CC=CC=C1)(C1=CC=CC=C1)C1=CC=CC=C1Cl

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Safety

HS Code: 2906290000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

H413May cause long lasting harmful effects to aquatic life

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PHR2700
Product name: Clotrimazole Related Compound A
Purity: Pharmaceutical Secondary Standard; Certified Reference Material
Packaging: 50MG
Price: $545.3
Updated: 2025/07/31

Sigma-Aldrich

Product number: BP079
Product name: 2-Chlorotritanol
Purity: British Pharmacopoeia (BP) Reference Standard
Packaging: 25 mg
Price: $227
Updated: 2025/07/31

TRC

Product number: C377905
Product name: (2-Chlorophenyl)diphenylmethanol
Packaging: 100mg
Price: $120
Updated: 2021/12/16

AK Scientific

Product number: J11479
Product name: ClotrimazolImpurezaA
Packaging: 25mg
Price: $101
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC162386
Product name: (2-Chlorophenyl)diphenylmethanol
Packaging: 25mg
Price: $150
Updated: 2021/12/16

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CLOTRIMAZOLE IMP. A (PHARMEUROPA): (2-CHLOROPHENYL)DIPHENYLMETHANOL Chemical Properties,Usage,Production

Chemical Properties

Crystallization. Melting point 84-86℃.

Uses

(2-Chlorophenyl)diphenylmethane is a triarylmethane with antiproliferative activity. (2-Chlorophenyl)diphenylmethane is a degradation product of the antifungal agent Clotrimazole (C587400).

Uses

(2-Chlorophenyl)diphenylmethane (Clotrimazole EP Impurity A) is a triarylmethane with antiproliferative activity. (2-Chlorophenyl)diphenylmethane is a degradation product of the antifungal agent Clotrimazole (C587400). Clotrimazole Related Compound A

Definition

ChEBI: TRAM-3 is an organochlorine compound.

CLOTRIMAZOLE IMP. A (PHARMEUROPA): (2-CHLOROPHENYL)DIPHENYLMETHANOL Preparation Products And Raw materials

Raw materials

Ethyl 2-Chlorobenzoate Bromobenzene 2-Chlorobenzoic acid PARA TOLUENE MAGNESIUM METHOXIDE Benzhydrol

Preparation Products

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66774-02-5, CLOTRIMAZOLE IMP. A (PHARMEUROPA): (2-CHLOROPHENYL)DIPHENYLMETHANOLRelated Search:

ROSE BENGAL Acid Red 92 2',4',5',7'-TETRABROMO-3,4,5,6-TETRACHLOROFLUORESCEIN CLOTRIMAZOLE IMP. A (PHARMEUROPA): (2-CHLOROPHENYL)DIPHENYLMETHANOL 3,4,5,6-TETRACHLOROFLUORESCEIN ROSE BENGAL Clotrimazole FMOC-ASP(OTBU)-2-CHLOROTRITYL RESIN FMOC-D-TYR(2-CLTRT)-OH FMOC-TYR(2-CLTRT)-OH FMOC-GLY-2-CHLOROTRITYL RESIN ROSE BENGAL LACTONE FMOC-L-VALINE-2-CHLOROTRITYL RESIN FMOC-MET-2-CL-TRT RESIN FMOC-LEU-2-CL-TRT RESIN FMOC-ALA-2-CL-TRT RESIN BENGALE ROSE 4,5,6,7-TETRACHLORO-2',4',5',7'-TETRAIODOFLUORESCEIN Clotrimazole Related Compound A

Clotrimazole EP Impurity A(USP RC A)

o-chlorotriphenylmethanol

Clotrimazole EP Impurity A

ClotriMazole Related CoMpound A

Benzenemethanol, 2-chloro-α,α-diphenyl-

Clotrimazole ImpuritⅠ:(2-chlorophenyl)diphenylmethanol

Clotrimazole Impurity 1(Clotrimazole EP Impurity A)

ClotriMazole IMpurity A

NSC 170882

TRAM 3

CLOTRIMAZOLE IMP. A (PHARMEUROPA): (2-CHLOROPHENYL)DIPHENYLMETHANOL

2-CHLOROPHENYL DIPHENYL METHANOL

(O-CHLOROPHENYL)DIPHENYL MENTHANOL

2-Chloro-,-diphenylbenzenemethanol

2-Chlorotrityl alcohol

2-Chloro-α,α-diphenylbenzyl alcohol

α,α-Diphenyl-2-chlorobenzenemethanol

Clotrimazole Related Compound A (25 mg) ((o-chlorophenyl)diphenylmethanol)

ClotriMazole IMp. A (EP): (2-Chlorophenyl)-diphenylMethanol

(o-Chlorophenyl)diphenylmethanol

CLOTRIMAZOLE IMP. A (PHARMEUROPA)

MDK-4025

Clotrimazole EP Impurity A/ Clotrimazole USP Related Compound A

Clotrimazole Related Compound A ((o-chlorophenyl)diphenylmethanol) (1141024)

Clotrimazole USP Related Compound A

MDK 4025,MDK4025

(2-Chlorophenyl)diphenylmethanol（Clotrimazole impurity I）

REFERENCE STANDARDS 2-Chorotritanol (Clotrimazole EP Impurity A) EPRS-25 MG

(2-Chlorophenyl)diphenylmethanol (Clotrimazole Impurity)

CLOTRIMAZOLE EP IMPURITY A/2- CHLOROTRITANOL

66774-02-5

C19H15ClO

Aromatics

Impurities

Intermediates & Fine Chemicals

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