ChemicalBook > CAS DataBase List > BRADYKININ, ACETATE SALT, 98

BRADYKININ, ACETATE SALT, 98

Product Name
BRADYKININ, ACETATE SALT, 98
CAS No.
6846-03-3
Chemical Name
BRADYKININ, ACETATE SALT, 98
Synonyms
Bradykinin xacetate salt;BRADYKININ, ACETATE SALT, 98;Bradykinin acetate salt powder, ≥ 98%;Bradykinin BK, Kallidin I, Kallidin-9, BRS-640;Bradykinin (human, mouse, rat, bovine) (acetate)
CBNumber
CB4501833
Molecular Formula
C50H73N15O11
Formula Weight
1060.22
MOL File
6846-03-3.mol
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BRADYKININ, ACETATE SALT, 98 Property

storage temp. 
Store at 0°C
solubility 
≥113 mg/mL in DMSO with gentle warming; ≥113.5 mg/mL in EtOH with gentle warming; ≥226.6 mg/mL in H2O
form 
powder
color 
white
Water Solubility 
Soluble in water.
Stability:
Hygroscopic
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Safety

WGK Germany 
3
HS Code 
2937190000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
B3259
Product name
Bradykinin acetate salt
Purity
powder, ≥98% (HPLC)
Packaging
5mg
Price
$80.5
Updated
2024/03/01
Sigma-Aldrich
Product number
B3259
Product name
Bradykinin acetate salt
Purity
powder, ≥98% (HPLC)
Packaging
10mg
Price
$122
Updated
2024/03/01
Alfa Aesar
Product number
J60345
Product name
Bradykinin acetate salt
Packaging
25mg
Price
$207
Updated
2023/06/20
Alfa Aesar
Product number
J60345
Product name
Bradykinin acetate salt
Packaging
100mg
Price
$420
Updated
2023/06/20
Cayman Chemical
Product number
15539
Product name
Bradykinin (acetate)
Purity
≥95%
Packaging
5mg
Price
$35
Updated
2021/12/16
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BRADYKININ, ACETATE SALT, 98 Chemical Properties,Usage,Production

Chemical Properties

white fine crystalline powder

Uses

Bradykinin Acetate elicits vasoconstriction, a systemic blood pressure reflex, a stimulation of respiration, and contraction of the nictitating membrane. Bradykinin plays an important role in the regulation of fluid and electrolyte balance, smooth muscle contraction, vasodilation and capillary permeability.

Biological Activity

bradykinin (acetate) is a well-known 9-amino acid endogenous vasoactive peptide and a systemic vasodilator [1].bradykinin is a potent endothelium-dependent vasodilator, leading to the reduction in blood pressure. it also induces contraction of non-vascular smooth muscle in the bronchus and gut, increases vascular permeability and is also involved in the mechanism of pain. bradykinin is an inflammatory mediator. the bradykinin b1 receptor is expressed only as a result of tissue injury and plays a role in inflammation. the bradykinin b2 receptor is constitutively expressed and participates in bradykinin's vasodilatory role.in cultured endothelial cells, bradykinin promoted a rapid dissociation of the enos:b2 receptor complex [2]. in the mouse gastrointestinal tract and pancreas, bradykinin stimulated extravasation from postcapillary venules by two- to sevenfold by interacting with b2 receptors and stimulating tachykinin release from sensory nerves [3].in healthy men, bradykinin (100-3200 ng/kg min) dose-related increased plasma concentrations of 6-oxo-pgf1a , the stable hydrolysis product of prostacyclin (pgi2). so bradykinin may have a use as a probe of pg12 production in vivo in pathological states [1].

Biochem/physiol Actions

Bradykinin is a pro-inflammatory peptide that acts through G-protein-coupled receptors. It activates sphingolipid metabolism. Fibroblasts treated with bradykinin produce a rapid and important increase in ceramide which is followed by a transient rise in sphingosine content. The peptide also increases ceramide cellular content by rapidly mobilizing neutral glycolipids. Bradykinin plays an important role in the regulation of fluid and electrolyte balance, smooth muscle contraction, vasodilation and capillary permeability. The bradykinin potentiators, which possess no bradykinin activity themselves, enhance the activity of bradykinin.

References

[1]. barrow se, dollery ct, heavey dj, et al. effect of vasoactive peptides on prostacyclin synthesis in man. br j pharmacol. 1986 jan;87(1):243-7.
[2]. ju h, venema vj, marrero mb, et al. inhibitory interactions of the bradykinin b2 receptor with endothelial nitric-oxide synthase. j biol chem. 1998 sep 11;273(37):24025-9.
[3]. figini m, emanueli c, grady ef, et al. substance p and bradykinin stimulate plasma extravasation in the mouse gastrointestinal tract and pancreas. am j physiol. 1997 apr;272(4 pt 1):g785-93.

BRADYKININ, ACETATE SALT, 98 Preparation Products And Raw materials

Raw materials

Preparation Products

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BRADYKININ, ACETATE SALT, 98 Suppliers

3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15839
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69
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Country
China
ProdList
42958
Advantage
64
Cellmano Biotech Limited
Tel
0551-65326643 18156095617
Fax
0551-65326641
Email
info@cellmano.com
Country
China
ProdList
1011
Advantage
55
Hangzhou Sage Chemical Co., Ltd.
Tel
+86057186818502 13588463833
Fax
Pls mail us for more information!
Email
info@sagechem.com
Country
China
ProdList
10266
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Sichuan Wei Keqi Biological Technology Co., Ltd.
Tel
028-81700200 18116577057
Fax
028-81705658
Email
3003855609@qq.com
Country
China
ProdList
7887
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56
Wuxi Zhongkun Biochemical Technology Co., Ltd.
Tel
0510-85629785 18013409632
Fax
051085625359
Email
sales@reading-chemicals.com
Country
China
ProdList
15178
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Sigma-Aldrich
Tel
021-61415566 800-8193336
Email
orderCN@merckgroup.com
Country
China
ProdList
51456
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Creative Peptides
Tel
Email
info@creative-peptides.com
Country
United States
ProdList
6083
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Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9806
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58
Chengdu Youngshe Chemical Co., Ltd.
Tel
+86-17380623303 +86-17380623303
Fax
028-62328193
Email
Caroline@youngshechem.com
Country
China
ProdList
4841
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6846-03-3, BRADYKININ, ACETATE SALT, 98Related Search:


  • BRADYKININ, ACETATE SALT, 98
  • Bradykinin BK, Kallidin I, Kallidin-9, BRS-640
  • Bradykinin xacetate salt
  • Bradykinin acetate salt powder, ≥ 98%
  • Bradykinin (human, mouse, rat, bovine) (acetate)
  • 6846-03-3
  • C50H73N15O11xC2H4O2
  • C50H73N15O11C2H4O2