BRADYKININ, ACETATE SALT, 98
- Product Name
- BRADYKININ, ACETATE SALT, 98
- CAS No.
- 6846-03-3
- Chemical Name
- BRADYKININ, ACETATE SALT, 98
- Synonyms
- Bradykinin xacetate salt;BRADYKININ, ACETATE SALT, 98;Bradykinin acetate salt powder, ≥ 98%;Bradykinin BK, Kallidin I, Kallidin-9, BRS-640;Bradykinin (human, mouse, rat, bovine) (acetate)
- CBNumber
- CB4501833
- Molecular Formula
- C50H73N15O11
- Formula Weight
- 1060.22
- MOL File
- 6846-03-3.mol
BRADYKININ, ACETATE SALT, 98 Property
- storage temp.
- Store at 0°C
- solubility
- ≥113 mg/mL in DMSO with gentle warming; ≥113.5 mg/mL in EtOH with gentle warming; ≥226.6 mg/mL in H2O
- form
- powder
- color
- white
- Water Solubility
- Soluble in water.
- Stability:
- Hygroscopic
Safety
- WGK Germany
- 3
- HS Code
- 2937190000
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- B3259
- Product name
- Bradykinin acetate salt
- Purity
- powder, ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $80.5
- Updated
- 2024/03/01
- Product number
- B3259
- Product name
- Bradykinin acetate salt
- Purity
- powder, ≥98% (HPLC)
- Packaging
- 10mg
- Price
- $122
- Updated
- 2024/03/01
- Product number
- J60345
- Product name
- Bradykinin acetate salt
- Packaging
- 25mg
- Price
- $207
- Updated
- 2023/06/20
- Product number
- J60345
- Product name
- Bradykinin acetate salt
- Packaging
- 100mg
- Price
- $420
- Updated
- 2023/06/20
- Product number
- 15539
- Product name
- Bradykinin (acetate)
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $35
- Updated
- 2021/12/16
BRADYKININ, ACETATE SALT, 98 Chemical Properties,Usage,Production
Chemical Properties
white fine crystalline powder
Uses
Bradykinin Acetate elicits vasoconstriction, a systemic blood pressure reflex, a stimulation of respiration, and contraction of the nictitating membrane. Bradykinin plays an important role in the regulation of fluid and electrolyte balance, smooth muscle contraction, vasodilation and capillary permeability.
Biological Activity
bradykinin (acetate) is a well-known 9-amino acid endogenous vasoactive peptide and a systemic vasodilator [1].bradykinin is a potent endothelium-dependent vasodilator, leading to the reduction in blood pressure. it also induces contraction of non-vascular smooth muscle in the bronchus and gut, increases vascular permeability and is also involved in the mechanism of pain. bradykinin is an inflammatory mediator. the bradykinin b1 receptor is expressed only as a result of tissue injury and plays a role in inflammation. the bradykinin b2 receptor is constitutively expressed and participates in bradykinin's vasodilatory role.in cultured endothelial cells, bradykinin promoted a rapid dissociation of the enos:b2 receptor complex [2]. in the mouse gastrointestinal tract and pancreas, bradykinin stimulated extravasation from postcapillary venules by two- to sevenfold by interacting with b2 receptors and stimulating tachykinin release from sensory nerves [3].in healthy men, bradykinin (100-3200 ng/kg min) dose-related increased plasma concentrations of 6-oxo-pgf1a , the stable hydrolysis product of prostacyclin (pgi2). so bradykinin may have a use as a probe of pg12 production in vivo in pathological states [1].
Biochem/physiol Actions
Bradykinin is a pro-inflammatory peptide that acts through G-protein-coupled receptors. It activates sphingolipid metabolism. Fibroblasts treated with bradykinin produce a rapid and important increase in ceramide which is followed by a transient rise in sphingosine content. The peptide also increases ceramide cellular content by rapidly mobilizing neutral glycolipids. Bradykinin plays an important role in the regulation of fluid and electrolyte balance, smooth muscle contraction, vasodilation and capillary permeability. The bradykinin potentiators, which possess no bradykinin activity themselves, enhance the activity of bradykinin.
References
[1]. barrow se, dollery ct, heavey dj, et al. effect of vasoactive peptides on prostacyclin synthesis in man. br j pharmacol. 1986 jan;87(1):243-7.
[2]. ju h, venema vj, marrero mb, et al. inhibitory interactions of the bradykinin b2 receptor with endothelial nitric-oxide synthase. j biol chem. 1998 sep 11;273(37):24025-9.
[3]. figini m, emanueli c, grady ef, et al. substance p and bradykinin stimulate plasma extravasation in the mouse gastrointestinal tract and pancreas. am j physiol. 1997 apr;272(4 pt 1):g785-93.
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