ChemicalBook > CAS DataBase List > BRADYKININ, ACETATE SALT, 98

BRADYKININ, ACETATE SALT, 98

Product Name: BRADYKININ, ACETATE SALT, 98
CAS No.: 6846-03-3
Chemical Name: BRADYKININ, ACETATE SALT, 98
Synonyms: Bradykinin Acetate (GMP);Bradykinin xacetate salt;BRADYKININ, ACETATE SALT, 98;Bradykinin acetate salt powder, ≥ 98%;Bradykinin, Bradykinin receptor agonist;Bradykinin BK, Kallidin I, Kallidin-9, BRS-640;Bradykinin (human, mouse, rat, bovine) (acetate);(S)-2-((S)-2-((S)-1-((S)-2-((S)-2-(2-((S)-1-((S)-1-((S)-2-amino-5-guanidinopentanoyl)pyrrolidine-2-carbonyl)pyrrolidine-2-carboxamido)acetamido)-3-phenylpropanamido)-3-hydroxypropanoyl)pyrrolidine-2-carboxamido)-3-phenylpropanamido)-5-guanidinopentanoic acid compound with acetic acid (1:1)
CBNumber: CB4501833
Molecular Formula: C50H73N15O11
Formula Weight: 1060.22
MOL File: 6846-03-3.mol

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BRADYKININ, ACETATE SALT, 98 Property

storage temp.: Store at 0°C
solubility: ≥113 mg/mL in DMSO with gentle warming; ≥113.5 mg/mL in EtOH with gentle warming; ≥226.6 mg/mL in H2O
form: powder
color: white
Water Solubility: Soluble in water.
Sequence: Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg
Stability:: Hygroscopic

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Safety

WGK Germany: 3
HS Code: 2937190000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: B3259
Product name: Bradykinin acetate salt
Purity: powder, ≥98% (HPLC)
Packaging: 5mg
Price: $82.8
Updated: 2025/07/31

Sigma-Aldrich

Product number: B3259
Product name: Bradykinin acetate salt
Purity: powder, ≥98% (HPLC)
Packaging: 10mg
Price: $125
Updated: 2025/07/31

Cayman Chemical

Product number: 15539
Product name: Bradykinin (acetate)
Purity: ≥95%
Packaging: 5mg
Price: $35
Updated: 2021/12/16

Cayman Chemical

Product number: 15539
Product name: Bradykinin (acetate)
Purity: ≥95%
Packaging: 10mg
Price: $60
Updated: 2021/12/16

Sigma-Aldrich

Product number: B3259
Product name: Bradykinin acetate salt
Purity: powder, ≥98% (HPLC)
Packaging: 1mg
Price: $33.1
Updated: 2025/07/31

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BRADYKININ, ACETATE SALT, 98 Chemical Properties,Usage,Production

Chemical Properties

white fine crystalline powder

Uses

Bradykinin Acetate elicits vasoconstriction, a systemic blood pressure reflex, a stimulation of respiration, and contraction of the nictitating membrane. Bradykinin plays an important role in the regulation of fluid and electrolyte balance, smooth muscle contraction, vasodilation and capillary permeability.

Biological Activity

bradykinin (acetate) is a well-known 9-amino acid endogenous vasoactive peptide and a systemic vasodilator [1].bradykinin is a potent endothelium-dependent vasodilator, leading to the reduction in blood pressure. it also induces contraction of non-vascular smooth muscle in the bronchus and gut, increases vascular permeability and is also involved in the mechanism of pain. bradykinin is an inflammatory mediator. the bradykinin b1 receptor is expressed only as a result of tissue injury and plays a role in inflammation. the bradykinin b2 receptor is constitutively expressed and participates in bradykinin's vasodilatory role.in cultured endothelial cells, bradykinin promoted a rapid dissociation of the enos:b2 receptor complex [2]. in the mouse gastrointestinal tract and pancreas, bradykinin stimulated extravasation from postcapillary venules by two- to sevenfold by interacting with b2 receptors and stimulating tachykinin release from sensory nerves [3].in healthy men, bradykinin (100-3200 ng/kg min) dose-related increased plasma concentrations of 6-oxo-pgf1a , the stable hydrolysis product of prostacyclin (pgi2). so bradykinin may have a use as a probe of pg12 production in vivo in pathological states [1].

Biochem/physiol Actions

Bradykinin is a pro-inflammatory peptide that acts through G-protein-coupled receptors. It activates sphingolipid metabolism. Fibroblasts treated with bradykinin produce a rapid and important increase in ceramide which is followed by a transient rise in sphingosine content. The peptide also increases ceramide cellular content by rapidly mobilizing neutral glycolipids. Bradykinin plays an important role in the regulation of fluid and electrolyte balance, smooth muscle contraction, vasodilation and capillary permeability. The bradykinin potentiators, which possess no bradykinin activity themselves, enhance the activity of bradykinin.

in vivo

Application of 1 μM bradykinin acetate to the ovary produces significant decreases in heart rate and mean arterial pressure. In vagotomized animals, application of 1 μM bradykinin acetate to the ovary produces bradycardia and hypotension similar to the responses evoked when vagal innervation is intact^[4].Vascular bradykinin acetate can improve pancreatic microcirculation and hemorheology in rats with severe acute pancreatitis. The pancreatic microcirculatory blood flow volume and velocity in the vascular bradykinin acetate treatment group increase gradually after 48 h^[5].PI3K/Akt signaling pathway activation induced by bradykinin administration reduces the activity of GSK-3β and MAPK, and reduces NF-x03BA; B level in the nucleus, thereby inhibiting TF expression. Consistent with this, intraperitoneal injection of C57/BL6 mice with bradykinin also inhibits the thrombus formation induced by ligation of inferior vena cava^[3].

IC 50

Bradykinin B2 Receptor (B2R); Human Endogenous Metabolite

References

[1]. barrow se, dollery ct, heavey dj, et al. effect of vasoactive peptides on prostacyclin synthesis in man. br j pharmacol. 1986 jan;87(1):243-7.
[2]. ju h, venema vj, marrero mb, et al. inhibitory interactions of the bradykinin b2 receptor with endothelial nitric-oxide synthase. j biol chem. 1998 sep 11;273(37):24025-9.
[3]. figini m, emanueli c, grady ef, et al. substance p and bradykinin stimulate plasma extravasation in the mouse gastrointestinal tract and pancreas. am j physiol. 1997 apr;272(4 pt 1):g785-93.

BRADYKININ, ACETATE SALT, 98 Preparation Products And Raw materials

Raw materials

Preparation Products

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6846-03-3, BRADYKININ, ACETATE SALT, 98Related Search:

Ethylenediaminetetraacetic acid Acetate BRADYKININ KALLIDIN KALLIDIN (HUMAN, BOVINE) 3ACOH 4H2O ARG-PRO-PRO-GLY-PHE-SER-PRO-PHE-ARG 2ACOH 3H2O LYS-ARG-PRO-HYP-GLY-PHE-SER-PRO-PHE-ARG 3ACOH 4H2O BOMBINAKININ M N-FORMYL-MET-LEU-PHE BRADYKININ TRIACETATE TRIHYDRATE BRADYKININ, ACETATE SALT, 98

BRADYKININ, ACETATE SALT, 98

Bradykinin BK, Kallidin I, Kallidin-9, BRS-640

Bradykinin xacetate salt

Bradykinin acetate salt powder, ≥ 98%

Bradykinin (human, mouse, rat, bovine) (acetate)

Bradykinin, Bradykinin receptor agonist

Bradykinin Acetate (GMP)

(S)-2-((S)-2-((S)-1-((S)-2-((S)-2-(2-((S)-1-((S)-1-((S)-2-amino-5-guanidinopentanoyl)pyrrolidine-2-carbonyl)pyrrolidine-2-carboxamido)acetamido)-3-phenylpropanamido)-3-hydroxypropanoyl)pyrrolidine-2-carboxamido)-3-phenylpropanamido)-5-guanidinopentanoic acid compound with acetic acid (1:1)

6846-03-3

C50H73N15O11xC2H4O2

C50H73N15O11C2H4O2