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IC86621

Product Name
IC86621
CAS No.
404009-40-1
Chemical Name
IC86621
Synonyms
IC 86621 (IC86621);IC 86621/404009-40-1;IC 86621, 10 mM in DMSO;IC86621 CAS#: 404009-40-1;IC86621(DNA-PK Inhibitor III);1-(2-hydroxy-4-Morpholinophenyl)ethanone;1-(2-Hydroxy-4-morpholinophenyl)ethan-1-one;Ethanone, 1-[2-hydroxy-4-(4-morpholinyl)phenyl]-;DNA-PK Inhibitor III - CAS 404009-40-1 - Calbiochem;1-(2-Hydroxy-4-morpholinophenyl)ethan-1-one , IC 86621
CBNumber
CB4503635
Molecular Formula
C12H15NO3
Formula Weight
221.25
MOL File
404009-40-1.mol
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IC86621 Property

Melting point:
98-100.3 °C
Boiling point:
425.5±45.0 °C(Predicted)
Density 
1.210±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO: 15 mg/mL
pka
10.47±0.10(Predicted)
form 
solid
color 
off-white
InChI
1S/C12H15NO3/c1-9(14)11-3-2-10(8-12(11)15)13-4-6-16-7-5-13/h2-3,8,15H,4-7H2,1H3
InChIKey
YHKSBKQXCWHTQL-UHFFFAOYSA-N
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Safety

WGK Germany 
3
Storage Class
11 - Combustible Solids
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
260962
Product name
DNA-PK Inhibitor III
Packaging
1mg
Price
$154
Updated
2023/01/07
TRC
Product number
H852750
Product name
1-(2-Hydroxy-4-morpholinophenyl)ethanone
Packaging
10mg
Price
$45
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0073228
Product name
1-(2-HYDROXY-4-MORPHOLINOPHENYL)ETHANONE
Purity
95.00%
Packaging
100MG
Price
$824.19
Updated
2021/12/16
AK Scientific
Product number
4512AH
Product name
1-(2-Hydroxy-4-morpholinophenyl)ethanone
Packaging
250mg
Price
$428
Updated
2021/12/16
Chemenu
Product number
CM314918
Product name
1-(2-Hydroxy-4-morpholin-4-yl-phenyl)ethanone
Purity
95%
Packaging
1g
Price
$571
Updated
2021/12/16
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IC86621 Chemical Properties,Usage,Production

Uses

IC 86621 is a potent DNA-dependent protein kinase (DNA-PK) inhibitor, with an IC50 of 120 nM. IC 86621 also acts as a selective and reversible ATP-competitive inhibitor.IC 86621 inhibits DNA-PK mediated cellular DNA double-strand break (DSB) repair (EC50=68 μM). IC 86621 increases DSB-induced antitumor activity without cytotoxic effects. IC 86621 can protects rheumatoid arthritis (RA) T cells from apoptosis[1][2].

Definition

ChEBI: 1-[2-hydroxy-4-(4-morpholinyl)phenyl]ethanone is an aromatic ketone.

General Description

A cell-permeable aryl-morpholino compound that acts as a potent, selective, reversible, and ATP-competitive inhibitor of DNA-PK (IC50 = 120 nM) and PI 3-Kinase catalytic subunit p110β (IC50 = 135 nM). It inhibits DNA-PK-mediated cellular DNA DSB (double strand break) repair (EC50 = 68 μM) and enhances DSB-induced antitumor activity both in vitro and in vivo, while exhibiting no cytotoxic effects (up to 50 μM) in the absence of DSBs. It inhibits PI 3-K p110α, p110γ, and p110δ only at much higher concentrations (IC50 = 1.4, 0.88, and 1.0 μM, respectively) and exhibits no effect against a panel of several other kinases, including, Cdk2, Src, PKA, PKC, Chk1, CK1, ATM, and FKBP12, even at concentrations as high as 100 μM.

Biochem/physiol Actions

Cell permeable: yes

References

[1] Chandra G, et al. Improved synthesis of a DNA-dependent protein kinase inhibitor IC86621. Arch Pharm Res. 2012 Mar;35(4):639-45. DOI:10.1007/s12272-012-0407-1
[2] Shao L, et al. DNA-dependent protein kinase catalytic subunit mediates T-cell loss in rheumatoid arthritis. EMBO Mol Med. 2010 Oct;2(10):415-27. DOI:10.1002/emmm.201000096

IC86621 Preparation Products And Raw materials

Raw materials

Preparation Products

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IC86621 Suppliers

China 25 India 1 Switzerland 1 United States 5 Global 32
VDM Biochemicals
Tel
0330-2528181
Fax
0330-2528171
Email
sales@vdmbio.com
Country
United States
ProdList
510
Advantage
64
Sigma-Aldrich
Tel
021-61415566 800-8193336
Email
orderCN@merckgroup.com
Country
China
ProdList
51395
Advantage
80
SanoChem (Chengdu) Tech. Co., Ltd.
Tel
28-87999436 02887999436
Fax
QQ:2746983436
Email
sales@sano-chem.com
Country
China
ProdList
3795
Advantage
55
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9803
Advantage
58
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
71826
Advantage
60
Shanghai Chaolan Chemical Technology Center
Tel
021-QQ：65489617 15618227136
Fax
21-5161 9052
Email
Sales@ATKchemical.com
Country
China
ProdList
9531
Advantage
58
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
Advantage
58
Jiangsu aikang biomedical research and development co., LTD
Tel
025-58859352 13155353615
Email
qzhang@aikonchem.com
Country
China
ProdList
15525
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32470
Advantage
58
Changzhou Chenhong Biotechnology Co., Ltd.
Tel
+86-0519-85788828 +86-13775037613
Email
sales@chemrenpharm.com
Country
China
ProdList
4023
Advantage
58

404009-40-1, IC86621Related Search:


  • DNA-PK Inhibitor III - CAS 404009-40-1 - Calbiochem
  • IC 86621 (IC86621)
  • 1-(2-hydroxy-4-Morpholinophenyl)ethanone
  • IC86621 CAS#: 404009-40-1
  • Ethanone, 1-[2-hydroxy-4-(4-morpholinyl)phenyl]-
  • 1-(2-Hydroxy-4-morpholinophenyl)ethan-1-one
  • ATP,Buchwald-Hartwig amination,Inhibitor,IC-86621,IC86621,IC 86621,DSB,antitumor,inhibit,Apoptosis,Fries rearrangement,DNA-dependent protein kinase,DNA-PK
  • 1-(2-Hydroxy-4-morpholinophenyl)ethan-1-one , IC 86621
  • IC 86621, 10 mM in DMSO
  • IC86621(DNA-PK Inhibitor III)
  • IC 86621/404009-40-1
  • 404009-40-1
  • 1-(2-Hydroxy-4-morpholin-4-yl-phenyl)ethanone
  • IC86621