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OLOMOUCINE II

Product Name
OLOMOUCINE II
CAS No.
500735-47-7
Chemical Name
OLOMOUCINE II
Synonyms
Nsc736738;Olomoucine II - CAS 500735-47-7 - Calbiochem;Olomoucine ii, 6-[(2-hydroxybenzyl)amino]-2-[1-(hydroxymethyl)propylamino]- 9-isopropylpurine;2-[[[2-[[(1R)-1-(Hydroxymethyl)propyl]amino]-9-(1-methylethyl)-9H-purin-6-yl]amino]methyl]phenol;Phenol, 2-[[[2-[[(1R)-1-(hydroxymethyl)propyl]amino]-9-(1-methylethyl)-9H-purin-6-yl]amino]methyl]-
CBNumber
CB4504061
Molecular Formula
C19H26N6O2
Formula Weight
370.45
MOL File
500735-47-7.mol
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OLOMOUCINE II Property

Boiling point:
618.5±65.0 °C(Predicted)
Density 
1.32
storage temp. 
−20°C
solubility 
chloroform: 50 mg/mL, soluble
form 
powder
pka
9.83±0.30(Predicted)
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Safety

Safety Statements 
22-24/25
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
495621
Product name
Olomoucine II
Packaging
5mg
Price
$308
Updated
2023/01/07
American Custom Chemicals Corporation
Product number
API0008354
Product name
OLOMOUCINE II
Purity
95.00%
Packaging
1MG
Price
$144.9
Updated
2021/12/16
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OLOMOUCINE II Chemical Properties,Usage,Production

Definition

ChEBI: 2-[[[2-(1-hydroxybutan-2-ylamino)-9-propan-2-yl-6-purinyl]amino]methyl]phenol is a thiopurine.

General Description

A cell-permeable 2,6,9-trisubstituted purine analog that acts as a potent, reversible, and ATP-competitive inhibitor of Cdk1/B with an IC50 of 20 nM and displays increased potency over purvalanol A (Cat. No. 540500; IC50 = 50 nM), Roscovitine (Cat. No. 557360; IC50 = 450 nM), Bohemine (Cat. No. 203600; IC50 = 1.1 μM) and Olomoucine (Cat. No. 495620; IC50 = 7.0 μM). Further, exerts greater in vitro cytotoxicity in various cancer cell lines (IC50 = 3.0 μM, 5.3 μM, 6.3 μM, 6.3 μM and 11.1 μM for CEM, MCF7, HOS, G631 and K562, respectively).

Biochem/physiol Actions

Cell permeable: yes

OLOMOUCINE II Preparation Products And Raw materials

Raw materials

Preparation Products

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OLOMOUCINE II Suppliers

China 5 Switzerland 1 United States 5 Global 11
Sigma-Aldrich
Tel
021-61415566 800-8193336
Email
orderCN@merckgroup.com
Country
China
ProdList
51456
Advantage
80
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9806
Advantage
58
ChemeGen 中国
Tel
18818260767
Fax
QQ 3610331285
Email
2625930290@qq.com
Country
China
ProdList
6973
Advantage
58
TargetMol Chemicals Inc.
Tel
4008200310
Email
marketing@tsbiochem.com
Country
China
ProdList
24647
Advantage
58
Guangzhou WeiBo Chemical Co., Ltd.
Tel
--
Fax
--
Email
weibochem@163.com
Country
China
ProdList
6187
Advantage
67

500735-47-7, OLOMOUCINE IIRelated Search:

Ro 3306 N9-ISOPROPYL-OLOMOUCINE (S)-ROSCOVITINE NU6140 3-amino-10H-acridine-9-thione ARCYRIAFLAVIN A PURVALANOL A 2(BIS-(HYDROXYETHYL)AMINO)-6-(4-METHOXYBENZYLAMINO)-9-ISOPROPYL-PURINE AMINOPURVALANOL A SU 9516 NU6102 OLOMOUCINE

  • Olomoucine II - CAS 500735-47-7 - Calbiochem
  • Nsc736738
  • Olomoucine ii, 6-[(2-hydroxybenzyl)amino]-2-[1-(hydroxymethyl)propylamino]- 9-isopropylpurine
  • 2-[[[2-[[(1R)-1-(Hydroxymethyl)propyl]amino]-9-(1-methylethyl)-9H-purin-6-yl]amino]methyl]phenol
  • Phenol, 2-[[[2-[[(1R)-1-(hydroxymethyl)propyl]amino]-9-(1-methylethyl)-9H-purin-6-yl]amino]methyl]-
  • 500735-47-7