ARCYRIAFLAVIN A

Product Name: ARCYRIAFLAVIN A
CAS No.: 118458-54-1
Chemical Name: ARCYRIAFLAVIN A
Synonyms: ARCYRIAFLAVIN A;ARCYRIAFLAVIN A, SYNTHETIC;12,13-DIHYDRO-5H-INDOLO[2,3-A]PYRROLO[3,4-C]CARBAZOLE-5,7(6H)-DIONE;5H-Indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione, 12,13-dihydro-
CBNumber: CB5311390
Molecular Formula: C20H11N3O2
Formula Weight: 325.32
MOL File: 118458-54-1.mol

More

Less

ARCYRIAFLAVIN A Property

Melting point:: >200 °C
Density: 1.621±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: Soluble in DMSO
form: Orange to red solid.
pka: 10.74±0.20(Predicted)
color: Brown to reddish brown

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

TCI Chemical

Product number: A3497
Product name: Arcyriaflavin A
Packaging: 20MG
Price: $164
Updated: 2026/03/19

Cayman Chemical

Product number: 13516
Product name: Arcyriaflavin A
Purity: ≥95%
Packaging: 1mg
Price: $57
Updated: 2024/03/01

Cayman Chemical

Product number: 13516
Product name: Arcyriaflavin A
Purity: ≥95%
Packaging: 5mg
Price: $139
Updated: 2024/03/01

Cayman Chemical

Product number: 13516
Product name: Arcyriaflavin A
Purity: ≥95%
Packaging: 10mg
Price: $220
Updated: 2024/03/01

Tocris

Product number: 2457
Product name: ArcyriaflavinA
Purity: ≥98%(HPLC)
Packaging: 10
Price: $223
Updated: 2021/12/16

More

Less

ARCYRIAFLAVIN A Chemical Properties,Usage,Production

Uses

Arcyriaflavin A is a potent inhibitor of CDK4/cyclin D1.

Definition

ChEBI: LSM-3627 is an indolocarbazole.

Biological Activity

Potent inhibitor of cdk4/cyclin D1 (IC 50 = 59 nM). Also active against CaM kinase II (IC 50 = 25 nM) but displays selectivity over several other kinases in vitro (IC 50 values for inhibition of PKA and PKC are > 2 and > 100 μ M respectively). Inhibits human cytomegalovirus (HCMV) replication in vitro (IC 50 = 200 nM).

in vitro

arcyriaflavin a is a potent, selective inhibitor of hcmv replication in cell culture, and the anti-hcmv activity appeared no relation to the inhibition of protein kinase c. the imide nh was identified to be essential for anti-hcmv activity [1]. arcyriaflavin a also has been showed the inhibitory activity against d1/cdk4 with a ic50 of 59 nm. based on x-ray co-crystal structure of staurosporine and the human cdk2, the acidic proton of the maleimide moiety and the carbonyl group play critical roles by acting as a hydrogen bond donor and acceptor in the atp binding pocket of cdk2 [2].

IC 50

0.2 μm for hcmv [1], 0.14 μm for d1–cdk4 [2]

References

[1] slater mj, cockerill s, baxter r, bonser rw, gohil k, gowrie c, robinson je, littler e, parry n, randall r, snowden w. indolocarbazoles: potent, selective inhibitors of human cytomegalovirus replication. bioorg med chem. 1999 jun;7(6):1067-74.
[2] zhu g, conner s, zhou x, shih c, brooks hb, considine e, dempsey ja, ogg c, patel b, schultz rm, spencer cd, teicher b, watkins sa. synthesis of quinolinyl/isoquinolinyl[a]pyrrolo [3,4-c] carbazoles as cyclin d1/cdk4 inhibitors. bioorg med chem lett. 2003 apr 7;13(7):1231-5.

ARCYRIAFLAVIN A Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

ARCYRIAFLAVIN A Suppliers

China 45 Germany 2 India 1 United Kingdom 2 United States 9 USA 1 Global 60

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15838
Advantage: 69

VDM Biochemicals

Tel: 0330-2528181
Fax: 0330-2528171
Email: sales@vdmbio.com
Country: United States
ProdList: 510
Advantage: 64

Synchem OHG

Tel: +49 5662 408730
Fax: +49 5662 4087320
Email: info@synchem.de
Country: Germany
ProdList: 4705
Advantage: 70

EMMX Biotechnology LLC

Tel: 888-539-0666
Fax: 888-539-0666
Email: info@emmx.com
Country: United States
ProdList: 8447
Advantage: 60

ShangHai Angti Biotechnology Co., Ltd.

Tel: 13764913901
Fax: -
Email: info@angtibio.com
Country: China
ProdList: 4975
Advantage: 55

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9803
Advantage: 58

Shanghai Chaolan Chemical Technology Center

Tel: 021-QQ：65489617 15618227136
Fax: 21-5161 9052
Email: Sales@ATKchemical.com
Country: China
ProdList: 9550
Advantage: 58

Zhengzhou Alfa Chemical Co.,Ltd

Tel: +8618530059196
Email: sale04@alfachem.cn
Country: China
ProdList: 9546
Advantage: 58

TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Country: United States
ProdList: 32467
Advantage: 58

Shanghai Dongyang Biotechnology Co., Ltd.

Tel: 0512-13601744364 13601744364
Email: chemsharker@126.com
Country: China
ProdList: 1141
Advantage: 58

118458-54-1, ARCYRIAFLAVIN ARelated Search:

SU 9516 NU6102 OLOMOUCINE PURVALANOL A 2(BIS-(HYDROXYETHYL)AMINO)-6-(4-METHOXYBENZYLAMINO)-9-ISOPROPYL-PURINE OLOMOUCINE II Ro 3306 N9-ISOPROPYL-OLOMOUCINE (S)-ROSCOVITINE NU6140 3-amino-10H-acridine-9-thione AMINOPURVALANOL A SB218078 ARCYRIAFLAVIN A N-ethoxycarbonyl-7-oxostaurosporine 2-BROMO-12,13-DIHYDRO-5H-INDOLO[2,3-A]PYRROLO[3,4-C]CARBAZOLE-5,7(6H)-DIONE 12-ETHYL-12,13-DIHYDRO-5H-INDOL[2,3A]PYRROLO[3,4C]CARBAZOLE-5,7(6H)-DIONE

12,13-DIHYDRO-5H-INDOLO[2,3-A]PYRROLO[3,4-C]CARBAZOLE-5,7(6H)-DIONE

ARCYRIAFLAVIN A

ARCYRIAFLAVIN A, SYNTHETIC

5H-Indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione, 12,13-dihydro-

118458-54-1

Cell Cycle Regulation