OLOMOUCINE II

Product Name: OLOMOUCINE II
CAS No.: 500735-47-7
Chemical Name: OLOMOUCINE II
Synonyms: Nsc736738;Olomoucine II - CAS 500735-47-7 - Calbiochem;Olomoucine ii, 6-[(2-hydroxybenzyl)amino]-2-[1-(hydroxymethyl)propylamino]- 9-isopropylpurine;2-[[[2-[[(1R)-1-(Hydroxymethyl)propyl]amino]-9-(1-methylethyl)-9H-purin-6-yl]amino]methyl]phenol;Phenol, 2-[[[2-[[(1R)-1-(hydroxymethyl)propyl]amino]-9-(1-methylethyl)-9H-purin-6-yl]amino]methyl]-
CBNumber: CB4504061
Molecular Formula: C19H26N6O2
Formula Weight: 370.45
MOL File: 500735-47-7.mol

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OLOMOUCINE II Property

Boiling point:: 618.5±65.0 °C(Predicted)
Density: 1.32
storage temp.: −20°C
solubility: chloroform: 50 mg/mL, soluble
form: powder
pka: 9.83±0.30(Predicted)

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Safety

Safety Statements: 22-24/25
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 495621
Product name: Olomoucine II
Packaging: 5mg
Price: $308
Updated: 2023/01/07

American Custom Chemicals Corporation

Product number: API0008354
Product name: OLOMOUCINE II
Purity: 95.00%
Packaging: 1MG
Price: $144.9
Updated: 2021/12/16

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OLOMOUCINE II Chemical Properties,Usage,Production

Definition

ChEBI: 2-[[[2-(1-hydroxybutan-2-ylamino)-9-propan-2-yl-6-purinyl]amino]methyl]phenol is a thiopurine.

General Description

A cell-permeable 2,6,9-trisubstituted purine analog that acts as a potent, reversible, and ATP-competitive inhibitor of Cdk1/B with an IC₅₀ of 20 nM and displays increased potency over purvalanol A (Cat. No. 540500; IC₅₀ = 50 nM), Roscovitine (Cat. No. 557360; IC₅₀ = 450 nM), Bohemine (Cat. No. 203600; IC₅₀ = 1.1 μM) and Olomoucine (Cat. No. 495620; IC₅₀ = 7.0 μM). Further, exerts greater in vitro cytotoxicity in various cancer cell lines (IC₅₀ = 3.0 μM, 5.3 μM, 6.3 μM, 6.3 μM and 11.1 μM for CEM, MCF7, HOS, G631 and K562, respectively).

Biochem/physiol Actions

Cell permeable: yes

OLOMOUCINE II Preparation Products And Raw materials

Raw materials

Preparation Products

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OLOMOUCINE II Suppliers

China 5 Switzerland 1 United States 5 Global 11

Sigma-Aldrich

Tel: 021-61415566 800-8193336
Email: orderCN@merckgroup.com
Country: China
ProdList: 51471
Advantage: 80

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9709
Advantage: 58

ChemeGen 中国

Tel: 18818260767
Fax: QQ 3610331285
Email: sales@chemegen.com
Country: China
ProdList: 6975
Advantage: 58

TargetMol Chemicals Inc.

Tel: 4008200310
Email: marketing@tsbiochem.com
Country: China
ProdList: 24023
Advantage: 58

Aladdin Scientific

Tel: +1-833-552-7181
Email: sales@aladdinsci.com
Country: United States
ProdList: 52927
Advantage: 58

500735-47-7, OLOMOUCINE IIRelated Search:

Ro 3306 N9-ISOPROPYL-OLOMOUCINE (S)-ROSCOVITINE NU6140 3-amino-10H-acridine-9-thione ARCYRIAFLAVIN A PURVALANOL A 2(BIS-(HYDROXYETHYL)AMINO)-6-(4-METHOXYBENZYLAMINO)-9-ISOPROPYL-PURINE AMINOPURVALANOL A SU 9516 NU6102 OLOMOUCINE

Olomoucine II - CAS 500735-47-7 - Calbiochem

Nsc736738

Olomoucine ii, 6-[(2-hydroxybenzyl)amino]-2-[1-(hydroxymethyl)propylamino]- 9-isopropylpurine

2-[[[2-[[(1R)-1-(Hydroxymethyl)propyl]amino]-9-(1-methylethyl)-9H-purin-6-yl]amino]methyl]phenol

Phenol, 2-[[[2-[[(1R)-1-(hydroxymethyl)propyl]amino]-9-(1-methylethyl)-9H-purin-6-yl]amino]methyl]-

500735-47-7