ChemicalBook > CAS DataBase List > 2-CHLORO-3-HYDROXYBENZALDEHYDE 97

2-CHLORO-3-HYDROXYBENZALDEHYDE 97

Product Name: 2-CHLORO-3-HYDROXYBENZALDEHYDE 97
CAS No.: 56962-10-8
Chemical Name: 2-CHLORO-3-HYDROXYBENZALDEHYDE 97
Synonyms: 2-chloro-3-hydroxy-;Benzaldehyde, 2-chloro-3-hydroxy-;2-CHLORO-3-HYDROXYBENZALDEHYDE 97;2-Chloro-3-hydroxybenzaldehyde 97%
CBNumber: CB4505396
Molecular Formula: C7H5ClO2
Formula Weight: 156.57
MOL File: 56962-10-8.mol

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2-CHLORO-3-HYDROXYBENZALDEHYDE 97 Property

Melting point:: 139-143 °C (lit.)
Boiling point:: 245.0±20.0 °C(Predicted)
Density: 1.404±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
form: solid
pka: 7.77±0.10(Predicted)
color: Off-white to faint orange
InChIKey: SEEAPLJEIJXFFU-UHFFFAOYSA-N

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Safety

Hazard Codes: Xn,N
Risk Statements: 22-37/38-41-50
Safety Statements: 26-36-60-61
RIDADR: UN 3077 9/PG 3
WGK Germany: 2
HazardClass: 9
PackingGroup: Ⅲ
HS Code: 2913000090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

H400Very toxic to aquatic life

Precautionary statements

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 647365
Product name: 2-Chloro-3-hydroxybenzaldehyde
Purity: 97%
Packaging: 1g
Price: $57
Updated: 2023/01/07

Sigma-Aldrich

Product number: 647365
Product name: 2-Chloro-3-hydroxybenzaldehyde
Purity: 97%
Packaging: 10g
Price: $248
Updated: 2023/01/07

TRC

Product number: C459100
Product name: 2-chloro-3-hydroxy-Benzaldehyde
Packaging: 500mg
Price: $65
Updated: 2021/12/16

Oakwood

Product number: 228235
Product name: 2-Chloro-3-hydroxybenzaldehyde
Purity: 95%
Packaging: 250mg
Price: $21
Updated: 2021/12/16

AK Scientific

Product number: 8348AB
Product name: 2-Chloro-3-hydroxybenzaldehyde
Packaging: 5g
Price: $141
Updated: 2021/12/16

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2-CHLORO-3-HYDROXYBENZALDEHYDE 97 Chemical Properties,Usage,Production

Uses

2-chloro-3-hydroxy-Benzaldehyde is a versatile building block used in the preparation of positional isomers of NOSH-aspirin a dual nitric oxide and hydrogen sulfide releasing hybrid pharmaceutical.

Synthesis

100-83-4

56962-10-8

Under stirring conditions, tBuOCl (20 mL, 176 mmol) was slowly added dropwise to a suspension of 3-hydroxybenzaldehyde (20.12 g, 160 mmol) in HOAc (40 mL). The reaction solution gradually changed to a clarified solution with significant exothermic phenomenon. The reaction mixture was cooled and stirred continuously for 16 h, during which a white precipitate was generated. The solid product was collected by filtration, washed with deionized water and dried to afford 2-chloro-3-hydroxybenzaldehyde (13.77 g, 55% yield), which was analyzed by GCMS (EI) showing m/z 156,158 (M+). Subsequently, 2-chloro-3-hydroxybenzaldehyde (4.55 g, 29 mmol) was dissolved in DMF (30 mL), and K2CO3 (4.8 g, 34.9 mmol) and MeI (2.7 mL, 43.6 mmol) were added sequentially, and the reaction was stirred for 16 h at room temperature. After the reaction was completed, the solvent was removed by distillation under reduced pressure, and the residue was dissolved with ethyl acetate, washed with water and saturated saline in turn, dried over anhydrous Na2SO4 and concentrated. Purification was carried out by silica gel column chromatography with ethyl acetate/hexane (1:5) as eluent to obtain 2-chloro-3-methoxybenzaldehyde 3a (4.68 g, 94% yield) as a colorless oil, which was solidified after standing.GCMS (EI) analysis showed m/z 170,172 (M+).

References

[1] ACS Catalysis, 2018, vol. 8, # 5, p. 4033 - 4043
[2] Australian Journal of Chemistry, 2005, vol. 58, # 8, p. 565 - 571
[3] Patent: WO2005/7164, 2005, A1. Location in patent: Page 30-31
[4] Patent: WO2005/7165, 2005, A1. Location in patent: Page 46
[5] Patent: WO2005/7633, 2005, A1. Location in patent: Page 33

2-CHLORO-3-HYDROXYBENZALDEHYDE 97 Preparation Products And Raw materials

Raw materials

Preparation Products

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2-CHLORO-3-HYDROXYBENZALDEHYDE 97 Suppliers

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View Lastest Price from 2-CHLORO-3-HYDROXYBENZALDEHYDE 97 manufacturers

Career Henan Chemical Co

Product: 2-CHLORO-3-HYDROXYBENZALDEHYDE 97 56962-10-8
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 100KG
Release date: 2019-05-24

56962-10-8, 2-CHLORO-3-HYDROXYBENZALDEHYDE 97Related Search:

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2-Chloro-3-hydroxybenzaldehyde 97%

Benzaldehyde, 2-chloro-3-hydroxy-

2-chloro-3-hydroxy-

2-CHLORO-3-HYDROXYBENZALDEHYDE 97

56962-10-8

API intermediates

Building Blocks

Carbonyl Compounds

Chemical Synthesis

Organic Building Blocks

Aldehydes

Carbonyl Compounds