2-CHLORO-3-HYDROXY-4-METHOXYBENZALDEHYDE
- Product Name
- 2-CHLORO-3-HYDROXY-4-METHOXYBENZALDEHYDE
- CAS No.
- 37687-57-3
- Chemical Name
- 2-CHLORO-3-HYDROXY-4-METHOXYBENZALDEHYDE
- Synonyms
- AKOS B028960;chloroisovanilin;Chloroisovaniline;2-CHLOROISOVANILLIN;TIMTEC-BB SBB003704;2-CHLORO-3-HYDROXY-P-ANISALDEHYDE;a-Bromo-5'-fluoro-3'-methoxyacetophenone;2-CHLORO-3-HYDROXY-4-METHOXYBENZALDEHYDE;Benzaldehyde, 2-chloro-3-hydroxy-4-methoxy-;2-Chloro-3-hydroxy-4-methoxybenzaldehyde 97%
- CBNumber
- CB6472548
- Molecular Formula
- C8H7ClO3
- Formula Weight
- 186.59
- MOL File
- 37687-57-3.mol
2-CHLORO-3-HYDROXY-4-METHOXYBENZALDEHYDE Property
- Melting point:
- 204-208 °C(lit.)
- Boiling point:
- 291.3±35.0 °C(Predicted)
- Density
- 1.377±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- form
- solid
- pka
- 7.77±0.15(Predicted)
- Appearance
- White to off-white Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 565997
- Product name
- 2-Chloro-3-hydroxy-4-methoxybenzaldehyde
- Purity
- 97%
- Packaging
- 5g
- Price
- $197
- Updated
- 2023/06/20
- Product number
- C585850
- Product name
- 2-Chloro-3-hydroxy-4-methoxybenzaldehyde
- Packaging
- 500mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- FC30101
- Product name
- 2-Chloro-3-hydroxy-4-methoxybenzaldehyde
- Packaging
- 1g
- Price
- $52.5
- Updated
- 2021/12/16
- Product number
- FC30101
- Product name
- 2-Chloro-3-hydroxy-4-methoxybenzaldehyde
- Packaging
- 2g
- Price
- $84
- Updated
- 2021/12/16
- Product number
- OR929791
- Product name
- 2-Chloro-3-hydroxy-4-methoxybenzaldehyde
- Purity
- 95%
- Packaging
- 1g
- Price
- $124
- Updated
- 2021/12/16
2-CHLORO-3-HYDROXY-4-METHOXYBENZALDEHYDE Chemical Properties,Usage,Production
Uses
Reactant for:
- BODIPY fluorescent sensors
Synthesis
621-59-0
37687-57-3
Step 1 Synthesis of 2-chloro-3-hydroxy-4-methoxybenzaldehyde: 41.2 g (0.271 mol) of isovanillin was dissolved in 160 mL of 90% acetic acid under heating conditions. 29.41 g of tert-butyl hypochlorite (t-BuOCl) was added slowly and dropwise to the above solution at 35°C to 40°C. The reaction mixture was stirred at room temperature. The reaction mixture was stirred at room temperature for 3 hours, followed by the addition of 200 mL of ether. The mixture was allowed to stand overnight and the precipitated crystals were separated by filtration and washed with ether. The crude product (42.0 g) was purified by recrystallization from acetonitrile to give 35 g of 2-chloro-3-hydroxy-4-methoxybenzaldehyde in 69% yield. The melting point of the product was 203-205 °C. NMR hydrogen spectrum (90 MHz, DMSO-d6) δ: 3.94 (3H, s, OCH3), 7.10 (1H, d, Ar-H), 7.42 (1H, d, Ar-H), 9.84 (1H, s, CHO), 10.16 (1H, s, OH).
References
[1] Journal of Medicinal Chemistry, 1986, vol. 29, # 11, p. 2315 - 2325
[2] Organic Process Research and Development, 2001, vol. 5, # 1, p. 45 - 49
[3] Synlett, 2014, vol. 25, # 20, p. 2891 - 2894
[4] Journal of Organic Chemistry, 2012, vol. 77, # 2, p. 977 - 984
[5] Journal of Heterocyclic Chemistry, 1986, vol. 23, # 6, p. 1805 - 1814
2-CHLORO-3-HYDROXY-4-METHOXYBENZALDEHYDE Preparation Products And Raw materials
Raw materials
Preparation Products
2-CHLORO-3-HYDROXY-4-METHOXYBENZALDEHYDE Suppliers
- Tel
- 021-021-58432009 400-005-6266
- Fax
- 021-58436166
- sales8178@energy-chemical.com
- Country
- China
- ProdList
- 44801
- Advantage
- 61
- Tel
- 571-88199336 18957129209
- Fax
- 0571-88190523
- 309645123@qq.com
- Country
- China
- ProdList
- 53
- Advantage
- 64
- Tel
- 021-54306202 13764082696
- info@hanhongsci.com
- Country
- China
- ProdList
- 42934
- Advantage
- 64
- Tel
- 18652989687
- Fax
- +86-25-52131256
- sales@norris-pharm.com
- Country
- China
- ProdList
- 8878
- Advantage
- 55
- Tel
- 400-6206333 13167063860
- Fax
- 021-50323701
- anhua.mao@aladdin-e.com
- Country
- China
- ProdList
- 25003
- Advantage
- 65
- Tel
- 86-0755-86635001
- Fax
- 86-0755-22642228
- cantotech@126.com
- Country
- China
- ProdList
- 4566
- Advantage
- 55
- Tel
- 400-164-7117 13681763483
- Fax
- +86-21-61629029
- product02@bidepharm.com
- Country
- China
- ProdList
- 39966
- Advantage
- 60
- Tel
- 0510-85629785 18013409632
- Fax
- 051085625359
- sales@reading-chemicals.com
- Country
- China
- ProdList
- 15178
- Advantage
- 58
- Tel
- 021-11111111 11111111111
- Fax
- qq:546919421
- 546919421@qq.com
- Country
- China
- ProdList
- 3519
- Advantage
- 55
- Tel
- sales@ahpharmatech.com
- Country
- China
- ProdList
- 5734
- Advantage
- 55
View Lastest Price from 2-CHLORO-3-HYDROXY-4-METHOXYBENZALDEHYDE manufacturers
- Product
- 2-Chloro-3-Hydroxy-4-Methoxybenzaldehyde 37687-57-3
- Price
- US $65.00-20.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20ton
- Release date
- 2024-06-04
- Product
- 2-Chloro-3-hydroxy-4-methoxybenzaldehyde 37687-57-3
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- kgs
- Release date
- 2023-01-03
- Product
- 2-CHLORO-3-HYDROXY-4-METHOXYBENZALDEHYDE 37687-57-3
- Price
- US $6.60/KG
- Min. Order
- 1KG
- Purity
- 97%-99%
- Supply Ability
- 1kg -1000kg
- Release date
- 2020-01-02