ChemicalBook > CAS DataBase List > 2-CHLORO-3-HYDROXY-4-METHOXYBENZALDEHYDE

2-CHLORO-3-HYDROXY-4-METHOXYBENZALDEHYDE

Product Name: 2-CHLORO-3-HYDROXY-4-METHOXYBENZALDEHYDE
CAS No.: 37687-57-3
Chemical Name: 2-CHLORO-3-HYDROXY-4-METHOXYBENZALDEHYDE
Synonyms: AKOS B028960;chloroisovanilin;Chloroisovaniline;2-CHLOROISOVANILLIN;TIMTEC-BB SBB003704;2-CHLORO-3-HYDROXY-P-ANISALDEHYDE;a-Bromo-5'-fluoro-3'-methoxyacetophenone;2-CHLORO-3-HYDROXY-4-METHOXYBENZALDEHYDE;Benzaldehyde, 2-chloro-3-hydroxy-4-methoxy-;2-Chloro-3-hydroxy-4-methoxybenzaldehyde 97%
CBNumber: CB6472548
Molecular Formula: C8H7ClO3
Formula Weight: 186.59
MOL File: 37687-57-3.mol

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2-CHLORO-3-HYDROXY-4-METHOXYBENZALDEHYDE Property

Melting point:: 204-208 °C(lit.)
Boiling point:: 291.3±35.0 °C(Predicted)
Density: 1.377±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
form: solid
pka: 7.77±0.15(Predicted)
Appearance: White to off-white Solid

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
HS Code: 2913000090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 565997
Product name: 2-Chloro-3-hydroxy-4-methoxybenzaldehyde
Purity: 97%
Packaging: 5g
Price: $197
Updated: 2023/06/20

TRC

Product number: C585850
Product name: 2-Chloro-3-hydroxy-4-methoxybenzaldehyde
Packaging: 500mg
Price: $75
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC30101
Product name: 2-Chloro-3-hydroxy-4-methoxybenzaldehyde
Packaging: 2g
Price: $84
Updated: 2021/12/16

Apolloscientific

Product number: OR929791
Product name: 2-Chloro-3-hydroxy-4-methoxybenzaldehyde
Purity: 95%
Packaging: 1g
Price: $124
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC30101
Product name: 2-Chloro-3-hydroxy-4-methoxybenzaldehyde
Packaging: 5G
Price: $131.3
Updated: 2021/12/16

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2-CHLORO-3-HYDROXY-4-METHOXYBENZALDEHYDE Chemical Properties,Usage,Production

Uses

Reactant for:

BODIPY fluorescent sensors

Synthesis

621-59-0

37687-57-3

Step 1 Synthesis of 2-chloro-3-hydroxy-4-methoxybenzaldehyde: 41.2 g (0.271 mol) of isovanillin was dissolved in 160 mL of 90% acetic acid under heating conditions. 29.41 g of tert-butyl hypochlorite (t-BuOCl) was added slowly and dropwise to the above solution at 35°C to 40°C. The reaction mixture was stirred at room temperature. The reaction mixture was stirred at room temperature for 3 hours, followed by the addition of 200 mL of ether. The mixture was allowed to stand overnight and the precipitated crystals were separated by filtration and washed with ether. The crude product (42.0 g) was purified by recrystallization from acetonitrile to give 35 g of 2-chloro-3-hydroxy-4-methoxybenzaldehyde in 69% yield. The melting point of the product was 203-205 °C. NMR hydrogen spectrum (90 MHz, DMSO-d6) δ: 3.94 (3H, s, OCH3), 7.10 (1H, d, Ar-H), 7.42 (1H, d, Ar-H), 9.84 (1H, s, CHO), 10.16 (1H, s, OH).

References

[1] Journal of Medicinal Chemistry, 1986, vol. 29, # 11, p. 2315 - 2325
[2] Organic Process Research and Development, 2001, vol. 5, # 1, p. 45 - 49
[3] Synlett, 2014, vol. 25, # 20, p. 2891 - 2894
[4] Journal of Organic Chemistry, 2012, vol. 77, # 2, p. 977 - 984
[5] Journal of Heterocyclic Chemistry, 1986, vol. 23, # 6, p. 1805 - 1814

2-CHLORO-3-HYDROXY-4-METHOXYBENZALDEHYDE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-CHLORO-3-HYDROXY-4-METHOXYBENZALDEHYDE Suppliers

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View Lastest Price from 2-CHLORO-3-HYDROXY-4-METHOXYBENZALDEHYDE manufacturers

Hebei Zhuanglai Chemical Trading Co.,Ltd

Product: 2-Chloro-3-Hydroxy-4-Methoxybenzaldehyde 37687-57-3
Price: US $65.00-20.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20ton
Release date: 2024-06-04

Capot Chemical Co.,Ltd.

Product: 2-Chloro-3-hydroxy-4-methoxybenzaldehyde 37687-57-3
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: kgs
Release date: 2023-01-03

Career Henan Chemical Co

Product: 2-CHLORO-3-HYDROXY-4-METHOXYBENZALDEHYDE 37687-57-3
Price: US $6.60/KG
Min. Order: 1KG
Purity: 97%-99%
Supply Ability: 1kg -1000kg
Release date: 2020-01-02

37687-57-3, 2-CHLORO-3-HYDROXY-4-METHOXYBENZALDEHYDERelated Search:

2-Chloroveratraldehyde Quincarbate 5-CHLORO-4-HYDROXY-3-METHOXYBENZALDEHYDE,3-CHLORO-4-HYDROXY-5-METHOXYBENZALDEHYDE 2-CHLORO-3,4-DIMETHOXYBENZOIC ACID 2-CHLORO-3,4-DIMETHOXYBENZAMIDE 2-CHLORO-3-HYDROXY-4-METHOXYBENZOIC ACID METHYL 2-CHLORO-3,4-DIMETHOXYBENZOATE 2-CHLORO-3,4-DIMETHOXY-6-NITROBENZALDEHYDE ETHYL 2-CHLORO-3,4-DIMETHOXYBENZOATE 2-CHLORO-3-HYDROXY-4-METHOXYBENZALDEHYDE 2-BROMO-3-CHLORO-4-HYDROXY-5-METHOXYBENZALDEHYDE 2,6-DICHLORO-3,4-DIMETHOXYBENZALDEHYDE 2-CHLORO 3,4 DIMETHOXY BENZIL RARECHEM AL BF 0917 RARECHEM AL BE 0997 RARECHEM AL BI 0907 RARECHEM AL BI 0997 RARECHEM AL BE 0917

2-CHLOROISOVANILLIN

2-CHLORO-3-HYDROXY-4-METHOXYBENZALDEHYDE

2-CHLORO-3-HYDROXY-P-ANISALDEHYDE

2-Chloro-3-hydroxy-p-anisaldehyde, 2-Chloroisovanillin

Chloroisovaniline

2-Chloro-3-hydroxy-4-methoxybenzaldehyde 97%

TIMTEC-BB SBB003704

AKOS B028960

Benzaldehyde, 2-chloro-3-hydroxy-4-methoxy-

chloroisovanilin

a-Bromo-5'-fluoro-3'-methoxyacetophenone

37687-57-3

7687-57-3

CH3OC6H2ClOHCHO

C8H7CIO3

Organic Building Blocks

Building Blocks

Aldehydes

Carbonyl Compounds