Description
ChemicalBook > CAS DataBase List > DL-Selenomethionine

DL-Selenomethionine

Description
Product Name
DL-Selenomethionine
CAS No.
1464-42-2
Chemical Name
DL-Selenomethionine
Synonyms
Selenomethionine;Selenium methionine;seleniummethionine;Seleno-DL-methionine;C05335;DL-Se-Met;methionine,seleno;Methionine, seleno;DL-SELENOMETHIONINE;selenomethionine(van)
CBNumber
CB4505790
Molecular Formula
C5H11NO2Se
Formula Weight
196.11
MOL File
1464-42-2.mol
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DL-Selenomethionine Property

Melting point:
267-269 °C
Boiling point:
320.8±37.0 °C(Predicted)
storage temp. 
-20°C
solubility 
almost transparency in 1mol/L HCl
pka
2.26±0.10(Predicted)
form 
solid
color 
White to Almost white
Water Solubility 
soluble
Merck 
14,8441
BRN 
1758204
NIST Chemistry Reference
Butanoic acid, 2-amino-4-(methylseleno)-(1464-42-2)
EPA Substance Registry System
Butanoic acid, 2-amino-4-(methylseleno)- (1464-42-2)
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Safety

Hazard Codes 
T,N
Risk Statements 
23/25-33-50/53
Safety Statements 
20/21-28-45-60-61
RIDADR 
UN 3283
WGK Germany 
3
RTECS 
ES7110000
HazardClass 
6.1
PackingGroup 
III
HS Code 
2931909000
Hazardous Substances Data
1464-42-2(Hazardous Substances Data)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H373May cause damage to organs through prolonged or repeated exposure

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P273Avoid release to the environment.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P314Get medical advice/attention if you feel unwell.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
S3875
Product name
Seleno-DL-methionine
Purity
≥99% (TLC)
Packaging
1g
Price
$463
Updated
2024/03/01
Sigma-Aldrich
Product number
PHR2613
Product name
Selenomethionine
Packaging
200MG
Price
$200
Updated
2024/03/01
Sigma-Aldrich
Product number
S3875
Product name
Seleno-DL-methionine
Purity
≥99% (TLC)
Packaging
25mg
Price
$58.2
Updated
2023/06/20
TCI Chemical
Product number
S0462
Product name
DL-Selenomethionine
Purity
>98.0%(HPLC)(T)
Packaging
1g
Price
$255
Updated
2024/03/01
Sigma-Aldrich
Product number
S3875
Product name
Seleno-DL-methionine
Purity
≥99% (TLC)
Packaging
100mg
Price
$121
Updated
2024/03/01
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DL-Selenomethionine Chemical Properties,Usage,Production

Description

Preparation of 4'-Bromoacetanilide from Acetanilide.
Principle: Aromatic compounds can be conveniently brominated by the use of brominating agent, which is normally a solution of bromine in acetic acid. Bromination of activated aromatic compounds usually give 2, 4, 6-tribromo derivatives while moderately activating group like anilide give preferably the para bromo product.
Reaction:

Procedure: Dissolve 0.5 g acetanilide in 0.6 ml glacial acetic acid and add 2.5 ml bromine solution in acetic acid (25% w/v). Shake the mixture for 1 h. After 1 h, pour the mixture on to crushed ice (20 g) with stirring. Filter the separated product and wash with cold water. Dry the product, record the practical yield and re-crystallize it.
Re-crystallization: Dissolve the crude product in minimum amount of ethyl alcohol in a beaker by heating on a water bath. Filter the hot solution and cool the filtrate. The crystals of the product separate out. Filter, dry and record the melting point and TLC (using toluene as a solvent).

Description

Selenomethionine is the major form of selenium in plant foods. Selenomethionine is identical to methionine, except that selenium replaces the sulfur atom. The selenium consumed as selenocysteine is broken down to form alanine and hydrogen selenide (H2Se). The breakdown pathway of selenomethion- ine is not clear. Although selenium does not occur to a great extent as selenite in foods, selenite is readily used as a source of the element by humans and animals. Selenium also occurs as selenate in foods such as beet leaves, garlic, and cabbage.

DL-Selenomethionine is a selenium (Se) analogue of methionine in which sulfur is replaced with the trace element selenium. Selenomethionine (SeMet) can incorporate into proteins in place of methionine with no effects on protein structure and function, providing a mechanism for reversible Se storage in organs and tissues. Free selenium is incorporated into selenocysteine, an amino acid found in more than thirty selenoproteins including the glutathione peroxidases (GPx) enzymes, thioredoxin reductase (TR) and the iodothyronine deiodinase enzymes.

Uses

contrast agent

Uses

Selenium as selenite, DL-selenomethionine, and DL-selenocystine was equally effective in preventing liver necrosis, but factor 3 selenium was three times more effective than these forms (Burk, 1976; Schwarz and Foltz, 1958).

Definition

ChEBI: Selenomethionine is a selenoamino acid that is the selenium analogue of methionine. It has a role as a plant metabolite. It is a member of selenomethionines and a selenoamino acid.

Biological Functions

Most selenium in animal tissues is present as selenomethionine or selenocysteine. Selenomethionine, which cannot be synthesized by humans and is initially synthesized in plants, is incorporated randomly in place of methionine in a variety of proteins obtained from plant and animal sources. Selenium is present in varying amounts in these proteins, which are called selenium-containing proteins.
Selenomethionine is not known to have a physiological function separate from that of methionine.
Selenocysteine is present in animal selenoproteins that have been characterized (see below) and is the form of selenium that accounts for the biological activity of the element. In contrast to selenomethionine, there is no evidence that selenocysteine substitutes for cysteine in humans.

Biological Activity

Most dietary selenium is highly bioavailable. Selenomethionine, which is estimated to account for at least half of the dietary selenium, is absorbed by the same mechanism as methionine, and its selenium is made available for selenoprotein synthesis when it is catabolized via the transsulfuration pathway (Esaki et al., 1982). The bioavailability of selenium in the form of selenomethionine is greater than 90 percent (Thomson and Robinson, 1986). The selenium in selenocysteine, another significant dietary form, is also highly bioavailable (Swanson et al., 1991). There appear to be some minor dietary forms of selenium (especially present in fish) that have relatively low bioavailability, but these forms have not been identified (Cantor and Tarino, 1982). Selenate and selenite, two inorganic forms of selenium, have roughly equivalent bioavailability which generally exceeds 50 percent (Thomson and Robinson, 1986). Although they are not major dietary constituents, these inorganic forms are commonly used as selenium supplements.

Metabolism

Selenomethionine, derived mainly from plants, enters the methionine pool in the body and shares the fate of methionine until catabolized by the transsulfuration pathway. The resulting free selenocysteine is further broken down with liberation of a reduced form of the element, which is designated selenide (Esaki et al., 1982). Ingested selenite, selenate, and selenocysteine are all apparently metabolized directly to selenide. This selenide may be associated with a protein that serves as a chaperone (Lacourciere and Stadtman, 1998). The selenide can be metabolized to selenophosphate, the precursor of selenocysteine in selenoproteins (Ehrenreich et al., 1992) and of selenium in transfer RNA (Veres et al., 1992), or it can be converted to excretory metabolites (Mozier et al., 1988), some of which have been characterized as methylated forms.

Purification Methods

It crystallises in hexagonal plates from MeOH and H2O. [Klosterman & Painter J Am Chem Soc 69 2009 1949.] The L-isomer [3211-76-5] is purified by dissolving it in H2O, adjusting the pH to 5.5 with aqueous NH3, evaporating to near-dryness, and the residue is washed several times with absolute EtOH till a solid is formed and then recrystallise from Me2CO. It has m 266-268o(dec) [also 275o(dec)], and [] D +18.1o(c 1, N HCl). [Pande et al. J Org Chem 35 1440 1970, Beilstein 4 IV 3216.]

DL-Selenomethionine Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from DL-Selenomethionine manufacturers

Hebei Weibang Biotechnology Co., Ltd
Product
Selenomethionine 1464-42-2
Price
US $1.00-1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-10-30
Wuhan Senwayer Century Chemical Co.,Ltd
Product
DL-Selenomethionine 1464-42-2
Price
US $0.00-0.00/mg
Min. Order
25mg
Purity
99%
Supply Ability
60kg
Release date
2023-02-10
Shaanxi Dideu Medichem Co. Ltd
Product
DL-Selenomethionine 1464-42-2
Price
US $4656.00/KG
Min. Order
1KG
Purity
99.0%
Supply Ability
1000 tons
Release date
2024-07-25

1464-42-2, DL-SelenomethionineRelated Search:


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