ChemicalBook > CAS DataBase List > 4,4'-Bis(hydroxymethyl)-2,2'-bipyridine

4,4'-Bis(hydroxymethyl)-2,2'-bipyridine

Product Name
4,4'-Bis(hydroxymethyl)-2,2'-bipyridine
CAS No.
109073-77-0
Chemical Name
4,4'-Bis(hydroxymethyl)-2,2'-bipyridine
Synonyms
2,2'-Bi(pyridine-4-methanol);2,2'-Bipyridine-4,4'-dimethanol;2,2'-Bipyridine-4,4'-bismethanol;1,4,7,10,18-Pentaazacyclopentadecane;1,10-phenanthroline-8-carboxylicacid;2,2'-Bipyridine]-4,4'-diyldimethanol;4,4'is(hydroxymethyl)-2,2'-bipyridine;[2,2'-Bipyridine]-4,4'-diyldiMethanol;4,4'-Bis(hydroxymethyl)-2,2'-bipyridyl;4,4'-Bis(hydroxymethyl)-2,2'-bipyridine
CBNumber
CB4511508
Molecular Formula
C12H12N2O2
Formula Weight
216.24
MOL File
109073-77-0.mol
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4,4'-Bis(hydroxymethyl)-2,2'-bipyridine Property

Melting point:
170.6-171.4 °C
Boiling point:
450.4±40.0 °C(Predicted)
Density 
1.281±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
soluble in Methanol
form 
powder to crystal
pka
12.94±0.10(Predicted)
color 
White to Almost white
InChI
InChI=1S/C12H12N2O2/c15-7-9-1-3-13-11(5-9)12-6-10(8-16)2-4-14-12/h1-6,15-16H,7-8H2
InChIKey
RRXGRDMHWYLJSY-UHFFFAOYSA-N
SMILES
C1(C2=NC=CC(CO)=C2)=NC=CC(CO)=C1
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Safety

Safety Statements 
24/25
HS Code 
29333990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TCI Chemical
Product number
B3511
Product name
4,4'-Bis(hydroxymethyl)-2,2'-bipyridine
Purity
>95.0%(GC)(T)
Packaging
1g
Price
$185
Updated
2025/07/31
TCI Chemical
Product number
B3511
Product name
4,4'-Bis(hydroxymethyl)-2,2'-bipyridine
Purity
>95.0%(GC)(T)
Packaging
5g
Price
$555
Updated
2025/07/31
TRC
Product number
H939953
Product name
4,4''-bis(Hydroxymethyl)-2,2''-bipyridine
Packaging
50mg
Price
$45
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB10299
Product name
4,4'-Bis(hydroxymethyl)-2,2-bipyridine
Packaging
100mg
Price
$50
Updated
2021/12/16
ChemScene
Product number
CS-W004569
Product name
[2,2'-Bipyridine]-4,4'-diyldimethanol
Purity
≥98.0%
Packaging
1g
Price
$90
Updated
2021/12/16
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4,4'-Bis(hydroxymethyl)-2,2'-bipyridine Chemical Properties,Usage,Production

Uses

4,4‘-Bis(hydroxymethyl)-2,2’-bipyridine is a replication inhibitor that has been used in the treatment of cancer. It has also been shown to be effective in the treatment of metabolic disorders and chronic bronchitis.

Synthesis

1762-42-1

109073-77-0

The general procedure for the synthesis of 2,2'-bipyridine-4,4'-dimethanol from diethyl [2,2'-bipyridine]-4,4'-dicarboxylate was as follows: sodium borohydride (1.87 g, 49 mmol) was added to diethyl [2,2'-bipyridine]-4,4'-dicarboxylate (567 mg) dissolved in anhydrous ethanol (34 mL) , 1.89 mmol) suspension. The reaction mixture was refluxed for 3 hours. After completion of the reaction, it was cooled to room temperature and saturated ammonium chloride solution (24 mL/g NH4Cl) was added to quench the excess sodium borohydride. Subsequently, ethanol was removed by evaporation under reduced pressure. The resulting solid was dissolved in a minimal amount of water using an ultrasonic bath. The aqueous phase was extracted with ethyl acetate (5 x 34 mL) and the organic phases were combined and dried over anhydrous sodium sulfate. Finally, the organic phase was concentrated under reduced pressure to give a white powdery product in 91% yield.

References

[1] Chemical Communications, 2009, # 48, p. 7545 - 7547
[2] Electrochimica Acta, 2016, vol. 207, p. 313 - 320
[3] Journal of Physical Chemistry B, 1999, vol. 103, # 38, p. 8067 - 8079
[4] Patent: CN105793241, 2016, A. Location in patent: Paragraph 0129; 0159
[5] Tetrahedron, 2014, vol. 70, # 36, p. 6271 - 6275

4,4'-Bis(hydroxymethyl)-2,2'-bipyridine Preparation Products And Raw materials

Raw materials

Preparation Products

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4,4'-Bis(hydroxymethyl)-2,2'-bipyridine Suppliers

Americas 1 China 153 Europe 3 India 5 Japan 1 Switzerland 2 Ukraine 1 United Kingdom 5 United States 14 Global 185
J & K SCIENTIFIC LTD.
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18210857532; 18210857532
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86-10-82849933
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Meryer (Shanghai) Chemical Technology Co., Ltd.
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TCI (Shanghai) Development Co., Ltd.
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TOKYO CHEMICAL INDUSTRY CO., LTD.
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View Lastest Price from 4,4'-Bis(hydroxymethyl)-2,2'-bipyridine manufacturers

Shanghai UCHEM Inc.
Product
4,4'-Bis(hydroxymethyl)-2,2'-bipyridine 109073-77-0
Price
US $70.00-328.00/g
Min. Order
5g
Purity
0.98
Supply Ability
10kg
Release date
2024-10-25
Henan Fengda Chemical Co., Ltd
Product
4,4'-Bis(hydroxymethyl)-2,2'-bipyridine 109073-77-0
Price
US $32.00-1.40/kg
Min. Order
1kg
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-04-07
LY Global chemicals co.,ltd .
Product
4,4'-Bis(hydroxymethyl)-2,2'-bipyridine 109073-77-0
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
1000kg
Release date
2023-04-03

109073-77-0, 4,4'-Bis(hydroxymethyl)-2,2'-bipyridineRelated Search:

2,6-Lutidine 4,4'-Bipyridine Tris(hydroxymethyl)nitromethane DIPIPERIDINOMETHANE 2,2'-Bipyridine 2-(Hydroxymethyl)pyridine 2,5-PYRIDINEDICARBOXYLIC ACID Diethyl 1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate 2,2'-Bipyridine-4,4'-dicarboxylic acid DIBUTYL 2,2'-BIPYRIDINE-4,4'-DICARBOXYLATE CIS-BIS(ISOTHIOCYANATO)BIS(2,2-BIPYRIDYL-4,4-DICARBOXYLATO)-RUTHENIUM(II) 2,2'-BIQUINOLINE-4,4'-DICARBOXYLIC ACID DIPOTASSIUM SALT TRIHYDRATE Bicinchoninic Acid Disodium Salt 2,2'-Bicinchoninic Acid 4,4'-Bis(ethoxycarbonly)-2,2'-bipyridine 4,4'-Bis(methoxycarbonly)-2,2'-bipyridine 2,2':6',2''-TERPYRIDINE-4,4',4''-TRICARBOXYLIC ACID Hydroxymethyl

  • [2-[4-(hydroxymethyl)-2-pyridinyl]-4-pyridinyl]methanol
  • 2,2'-Bi(pyridine-4-methanol)
  • 2,2'-Bipyridine-4,4'-bismethanol
  • 2,2'-Bipyridine-4,4'-dimethanol
  • {2-[4-(hydroxyMethyl)pyridin-2-yl]pyridin-4-yl}Methanol
  • 4,4'-Bis(hydroxymethyl)-2,2'-bipyridine
  • 2,2'-Bipyridine-4,4'-dimethanol 4,4'-Bis(hydroxymethyl)-2,2'-bipyridyl
  • [2,2'-Bipyridine]-4,4'-diyldiMethanol
  • 4,4'is(hydroxymethyl)-2,2'-bipyridine
  • ４，４＇－Ｂｉｓ（ｈｙｄｒｏｘｙｍｅｔｈａｎｏｌ）－２，２＇－ｂｉｐｙｒｉｄｉｎｅ
  • [2-[4-(Hydroxymethyl)-2-pyridyl]-4-pyridyl]methanol
  • 4,4'-Bis(hydroxymethyl)-2,2'-bipyridine&gt
  • 4,4'-Bis(hydroxymethyl)-2,2'-bipyridyl
  • 4,4'-Bis(hydroxymethyl)-2,2'-bipyridine ISO 9001：2015 REACH
  • 1,4,7,10,18-Pentaazacyclopentadecane
  • 1,10-phenanthroline-8-carboxylicacid
  • 4,4'-Bis(hydroxymethyl)-2,2'-bipyridine iCAS NO.109073-77-0
  • 2,2'-Bipyridine]-4,4'-diyldimethanol
  • 109073-77-0
  • C12H12O2N2
  • Pyridines derivates