ChemicalBook > CAS DataBase List > 6-Bromo-4-hydroxy-pyrazolo[1,5-a]pyridine-3-carbonitrile

6-Bromo-4-hydroxy-pyrazolo[1,5-a]pyridine-3-carbonitrile

Product Name
6-Bromo-4-hydroxy-pyrazolo[1,5-a]pyridine-3-carbonitrile
CAS No.
2068065-16-5
Chemical Name
6-Bromo-4-hydroxy-pyrazolo[1,5-a]pyridine-3-carbonitrile
Synonyms
6-Bromo-4-hydroxy-pyrazolo[1,5-a]pyridine-3-carbonitrile;Pyrazolo[1,5-a]pyridine-3-carbonitrile, 6-bromo-4-hydroxy-
CBNumber
CB45441866
Molecular Formula
C8H4BrN3O
Formula Weight
238.04
MOL File
2068065-16-5.mol
More
Less

6-Bromo-4-hydroxy-pyrazolo[1,5-a]pyridine-3-carbonitrile Property

Density 
1.88±0.1 g/cm3(Predicted)
pka
6.41±0.30(Predicted)
InChI
InChI=1S/C8H4BrN3O/c9-6-1-7(13)8-5(2-10)3-11-12(8)4-6/h1,3-4,13H
InChIKey
IFUVDUFAFVWZOT-UHFFFAOYSA-N
SMILES
C12=C(C#N)C=NN1C=C(Br)C=C2O
More
Less

Hazard and Precautionary Statements (GHS)

More
Less

6-Bromo-4-hydroxy-pyrazolo[1,5-a]pyridine-3-carbonitrile Chemical Properties,Usage,Production

Uses

6-Bromo-4-hydroxy-pyrazolo[1,5-a]pyridine-3-carbonitrile is a pharmaceutical intermediate used in the preparation of Selpercatinib, an FDA-approved drug for the treatment of RET-positive advanced non-small cell lung cancer (NSCLC), thyroid cancer and certain other cancers

Synthesis

At room temperature, add 6-bromo-4-methoxypyrazolo[1,5-a]pyridine-3-carbonitrile (50g, 198.36mmol) and water (16.5mL, 916mmol) in a 1L single-neck flask in sequence, Sodium hydroxide (16.03g, 396.8mmol), DMA (500mL), stirred at room temperature for 5min, then transferred to 0°C, slowly added dodecanethiol (97mL, 397mmol), after the addition, the reaction was moved to 45°C overnight. Pour the reaction solution into 3L ice water, slowly add saturated citric acid water to adjust the PH=5, stir for half an hour, and then stand still filter, wash the filter cake with water and petroleum ether several times, and dry at 60°C to obtain 44.1g of yellow solid 6-Bromo-4-hydroxy-pyrazolo[1,5-a]pyridine-3-carbonitrile (6-Bromo-4-hydroxypyrazolo[1,5-a]pyridine-3-carbonitrile).

6-Bromo-4-hydroxy-pyrazolo[1,5-a]pyridine-3-carbonitrile Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

6-Bromo-4-hydroxy-pyrazolo[1,5-a]pyridine-3-carbonitrile Suppliers

Xiamen Yunfan Biotech Co., Ltd.
Tel
0592-7828678 18050056030
Fax
0592-7828678
Email
357187337@qq.com
Country
China
ProdList
59
Advantage
58
Suzhou Guide Fine Material Co., Ltd.
Tel
13914021065 13912645265
Email
lixm@guide-chemicals.com
Country
China
ProdList
236
Advantage
58
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44689
Advantage
61
Suzhou Ryan Pharmaceutical Technology Co., Ltd.
Tel
0512-68780025 18962125825
Email
sales@ryanchem.com
Country
China
ProdList
169
Advantage
62
ChengDu TongChuangYuan Pharmaceutical Co.Ltd
Tel
028-83379370 13880556291
Fax
028-87747383
Email
tcy@tcypharm.com
Country
China
ProdList
6274
Advantage
58
Hangzhou Chemtrue Bio-Tech Co.,Ltd.
Tel
0571-86828652 18857119830
Fax
0571-83522824
Email
sales@chemtrue-bio.com
Country
China
ProdList
328
Advantage
58
Biokitchen
Tel
021-021-021-31663258 13795219287
Fax
021-31663258
Email
donghuanwen@126.com
Country
China
ProdList
9885
Advantage
58
Aikon International Limited
Tel
025-66113011 13155353615
Fax
(7)02557626880
Email
qzhang@aikonchem.com
Country
China
ProdList
15394
Advantage
58
Labnetwork lnc.
Tel
+86-27-50766799 +8618062016861
Email
contact@labnetwork.com
Country
China
ProdList
19987
Advantage
58
HUNAN CHEMFISH SCIENTIFIC CO.,LTD
Tel
+86-0731-85567275 18932438858
Fax
QQ:3554193828
Email
sales05@chemfish.com
Country
China
ProdList
8332
Advantage
58
More
Less

View Lastest Price from 6-Bromo-4-hydroxy-pyrazolo[1,5-a]pyridine-3-carbonitrile manufacturers

Xiamen Yunfan Biotech Co.,Ltd.
Product
6-Bromo-4-hydroxy-pyrazolo[1,5-a]pyridine-3-carbonitrile 2068065-16-5
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
500Kilogram/Month
Release date
2024-05-14
Henan Fengda Chemical Co., Ltd
Product
6-Bromo-4-hydroxy-pyrazolo[1,5-a]pyridine-3-carbonitrile 2068065-16-5
Price
US $5.00-0.10/KG
Min. Order
1KG
Purity
98%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-04-09
Henan Aochuang Chemical Co.,Ltd.
Product
6-Bromo-4-hydroxy-pyrazolo[1,5-a]pyridine-3-carbonitrile 2068065-16-5
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1Ton
Release date
2022-10-08

2068065-16-5, 6-Bromo-4-hydroxy-pyrazolo[1,5-a]pyridine-3-carbonitrileRelated Search:


  • 6-Bromo-4-hydroxy-pyrazolo[1,5-a]pyridine-3-carbonitrile
  • Pyrazolo[1,5-a]pyridine-3-carbonitrile, 6-bromo-4-hydroxy-
  • 2068065-16-5