6-Bromo-4-hydroxy-pyrazolo[1,5-a]pyridine-3-carbonitrile
- Product Name
- 6-Bromo-4-hydroxy-pyrazolo[1,5-a]pyridine-3-carbonitrile
- CAS No.
- 2068065-16-5
- Chemical Name
- 6-Bromo-4-hydroxy-pyrazolo[1,5-a]pyridine-3-carbonitrile
- Synonyms
- 6-Bromo-4-hydroxy-pyrazolo[1,5-a]pyridine-3-carbonitrile;Pyrazolo[1,5-a]pyridine-3-carbonitrile, 6-bromo-4-hydroxy-
- CBNumber
- CB45441866
- Molecular Formula
- C8H4BrN3O
- Formula Weight
- 238.04
- MOL File
- 2068065-16-5.mol
6-Bromo-4-hydroxy-pyrazolo[1,5-a]pyridine-3-carbonitrile Property
- Density
- 1.88±0.1 g/cm3(Predicted)
- pka
- 6.41±0.30(Predicted)
- InChI
- InChI=1S/C8H4BrN3O/c9-6-1-7(13)8-5(2-10)3-11-12(8)4-6/h1,3-4,13H
- InChIKey
- IFUVDUFAFVWZOT-UHFFFAOYSA-N
- SMILES
- C12=C(C#N)C=NN1C=C(Br)C=C2O
6-Bromo-4-hydroxy-pyrazolo[1,5-a]pyridine-3-carbonitrile Chemical Properties,Usage,Production
Uses
6-Bromo-4-hydroxy-pyrazolo[1,5-a]pyridine-3-carbonitrile is a pharmaceutical intermediate used in the preparation of Selpercatinib, an FDA-approved drug for the treatment of RET-positive advanced non-small cell lung cancer (NSCLC), thyroid cancer and certain other cancers
Synthesis
At room temperature, add 6-bromo-4-methoxypyrazolo[1,5-a]pyridine-3-carbonitrile (50g, 198.36mmol) and water (16.5mL, 916mmol) in a 1L single-neck flask in sequence, Sodium hydroxide (16.03g, 396.8mmol), DMA (500mL), stirred at room temperature for 5min, then transferred to 0°C, slowly added dodecanethiol (97mL, 397mmol), after the addition, the reaction was moved to 45°C overnight. Pour the reaction solution into 3L ice water, slowly add saturated citric acid water to adjust the PH=5, stir for half an hour, and then stand still filter, wash the filter cake with water and petroleum ether several times, and dry at 60°C to obtain 44.1g of yellow solid 6-Bromo-4-hydroxy-pyrazolo[1,5-a]pyridine-3-carbonitrile (6-Bromo-4-hydroxypyrazolo[1,5-a]pyridine-3-carbonitrile).
6-Bromo-4-hydroxy-pyrazolo[1,5-a]pyridine-3-carbonitrile Preparation Products And Raw materials
Raw materials
Preparation Products
6-Bromo-4-hydroxy-pyrazolo[1,5-a]pyridine-3-carbonitrile Suppliers
- Tel
- 0592-7828678 18050056030
- Fax
- 0592-7828678
- 357187337@qq.com
- Country
- China
- ProdList
- 59
- Advantage
- 58
- Tel
- 13914021065 13912645265
- lixm@guide-chemicals.com
- Country
- China
- ProdList
- 236
- Advantage
- 58
- Tel
- 021-021-58432009 400-005-6266
- Fax
- 021-58436166
- sales8178@energy-chemical.com
- Country
- China
- ProdList
- 44689
- Advantage
- 61
- Tel
- 0512-68780025 18962125825
- sales@ryanchem.com
- Country
- China
- ProdList
- 169
- Advantage
- 62
- Tel
- 028-83379370 13880556291
- Fax
- 028-87747383
- tcy@tcypharm.com
- Country
- China
- ProdList
- 6274
- Advantage
- 58
- Tel
- 0571-86828652 18857119830
- Fax
- 0571-83522824
- sales@chemtrue-bio.com
- Country
- China
- ProdList
- 328
- Advantage
- 58
- Tel
- 021-021-021-31663258 13795219287
- Fax
- 021-31663258
- donghuanwen@126.com
- Country
- China
- ProdList
- 9885
- Advantage
- 58
- Tel
- 025-66113011 13155353615
- Fax
- (7)02557626880
- qzhang@aikonchem.com
- Country
- China
- ProdList
- 15394
- Advantage
- 58
- Tel
- +86-27-50766799 +8618062016861
- contact@labnetwork.com
- Country
- China
- ProdList
- 19987
- Advantage
- 58
- Tel
- +86-0731-85567275 18932438858
- Fax
- QQ:3554193828
- sales05@chemfish.com
- Country
- China
- ProdList
- 8332
- Advantage
- 58
View Lastest Price from 6-Bromo-4-hydroxy-pyrazolo[1,5-a]pyridine-3-carbonitrile manufacturers
- Product
- 6-Bromo-4-hydroxy-pyrazolo[1,5-a]pyridine-3-carbonitrile 2068065-16-5
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 500Kilogram/Month
- Release date
- 2024-05-14
- Product
- 6-Bromo-4-hydroxy-pyrazolo[1,5-a]pyridine-3-carbonitrile 2068065-16-5
- Price
- US $5.00-0.10/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-04-09
- Product
- 6-Bromo-4-hydroxy-pyrazolo[1,5-a]pyridine-3-carbonitrile 2068065-16-5
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-08