4(1H)-Quinolinone, 8-chloro-2-[(2,4-dichlorophenyl)amino]-3-(3-methyl-1-oxobutyl)-5-nitro-

Product Name: 4(1H)-Quinolinone, 8-chloro-2-[(2,4-dichlorophenyl)amino]-3-(3-methyl-1-oxobutyl)-5-nitro-
CAS No.: 1361227-90-8
Chemical Name: 4(1H)-Quinolinone, 8-chloro-2-[(2,4-dichlorophenyl)amino]-3-(3-methyl-1-oxobutyl)-5-nitro-
Synonyms: JH-RE-06;JH-RE-06 ，S8850;JH-RE-06, 10 mM in DMSO;JH RE 06,DNA/RNA Synthesis,inhibit,Inhibitor,JHRE06;8-Chloro-2-((2,4-dichlorophenyl)amino)-3-(3-methylbutanoyl)-5-nitroquinolin-4(1H)-one;4(1H)-Quinolinone, 8-chloro-2-[(2,4-dichlorophenyl)amino]-3-(3-methyl-1-oxobutyl)-5-nitro-
CBNumber: CB45486742
Molecular Formula: C20H16Cl3N3O4
Formula Weight: 468.72
MOL File: 1361227-90-8.mol

More

Less

4(1H)-Quinolinone, 8-chloro-2-[(2,4-dichlorophenyl)amino]-3-(3-methyl-1-oxobutyl)-5-nitro- Property

Boiling point:: 586.9±50.0 °C(Predicted)
Density: 1.503±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO: 5 mg/mL (10.67 mM)
pka: -3.78±0.70(Predicted)
form: Solid
color: White to yellow
InChI: 1S/C20H16Cl3N3O4/c1-9(2)7-15(27)17-19(28)16-14(26(29)30)6-4-11(22)18(16)25-20(17)24-13-5-3-10(21)8-12(13)23/h3-6,8-9H,7H2,1-2H3,(H2,24,25,28)
InChIKey: LRTXIQCBQIKIOH-UHFFFAOYSA-N
SMILES: Clc1c(ccc(c1)Cl)Nc2[nH]c3c([c](c2C(=O)CC(C)C)=O)c(ccc3Cl)[N+](=O)[O-]

More

Less

Safety

WGK Germany: WGK 3
Storage Class: 11 - Combustible Solids

More

Less

Hazard and Precautionary Statements (GHS)

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML2993
Product name: JH-RE-06
Purity: ≥98% (HPLC)
Packaging: 5MG
Price: $137
Updated: 2026/03/19

Sigma-Aldrich

Product number: SML2993
Product name: JH-RE-06
Purity: ≥98% (HPLC)
Packaging: 25MG
Price: $525
Updated: 2026/03/19

Axon Medchem

Product number: Axon3002
Product name: JH-RE-06
Purity: 99%
Packaging: 5mg
Price: $159.5
Updated: 2021/12/16

ChemScene

Product number: CS-0099826
Product name: JH-RE-06
Purity: 99.87%
Packaging: 1mg
Price: $350
Updated: 2021/12/16

ChemScene

Product number: CS-0099826
Product name: JH-RE-06
Purity: 99.87%
Packaging: 5mg
Price: $570
Updated: 2021/12/16

More

Less

4(1H)-Quinolinone, 8-chloro-2-[(2,4-dichlorophenyl)amino]-3-(3-methyl-1-oxobutyl)-5-nitro- Chemical Properties,Usage,Production

Uses

JH-RE-06-d6 is deuterium labele JH-RE-06. JH-RE-06, a potent REV1-REV7 interface inhibitor (IC50=0.78 μM; Ki=0.42 μM), targets REV1 that interacts with the REV7 subunit of POLζ. JH-RE-06 disrupts mutagenic translesion synthesis (TLS) by preventing recruitment of mutagenic POLζ. JH-RE-06 improves chemotherapy[1].

Biological Activity

JH-RE-06 is a potent and selective inhibitor of REV1-REV7 interaction th at induces REV1 dimerization blocking the REV1-REV7 interaction and POL ϲ recruitment. JH-RE-06 potently inhibits translesion synthesis (TLS) and augments cisplatin effectiveness in cultured human and mouse cell lines. It improves effectiveness of cisplatin in A375 tumor xenograft mouse model.

References

[1] Wojtaszek JL, et al. A Small Molecule Targeting Mutagenic Translesion Synthesis Improves Chemotherapy. Cell. 2019;178(1):152-159.e11. DOI:10.1016/j.cell.2019.05.028

4(1H)-Quinolinone, 8-chloro-2-[(2,4-dichlorophenyl)amino]-3-(3-methyl-1-oxobutyl)-5-nitro- Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

4(1H)-Quinolinone, 8-chloro-2-[(2,4-dichlorophenyl)amino]-3-(3-methyl-1-oxobutyl)-5-nitro- Suppliers

China 32 United States 3 Global 35

Shanghai Beckham Medical Technology Co., Ltd

Tel: 13816613772
Fax: QQ: 12922499
Email: huahero21@sina.com
Country: China
ProdList: 2519
Advantage: 55

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9803
Advantage: 58

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 86249
Advantage: 60

ShangHai Biochempartner Co.,Ltd

Tel: 177-54423994 17754423994
Fax: QQ:2853530913
Email: 2853530910@QQ.com
Country: China
ProdList: 7998
Advantage: 62

Fan De(Beijing) Biotechnology Co., Ltd.

Tel: 15911056312
Email: liming@bio-fount.com
Country: China
ProdList: 9729
Advantage: 58

TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Country: United States
ProdList: 32467
Advantage: 58

Chengdu Peter-like Biotechnology Co., Ltd.

Tel: 18108052721 18108052721;
Email: 2850505130@qq.com
Country: China
ProdList: 5088
Advantage: 58

Wuhan Dingtong Pharmaceutical Co., Ltd

Tel: 17771430860
Fax: 027-59207795
Email: 18327179646@163.com
Country: China
ProdList: 1923
Advantage: 58

Bide Pharmatech Ltd.

Tel: 400-1647117 13681763483
Email: product02@bidepharm.com
Country: China
ProdList: 59936
Advantage: 58

TargetMol Chemicals Inc.

Tel: 4008200310
Email: marketing@tsbiochem.com
Country: China
ProdList: 24960
Advantage: 58

1361227-90-8, 4(1H)-Quinolinone, 8-chloro-2-[(2,4-dichlorophenyl)amino]-3-(3-methyl-1-oxobutyl)-5-nitro-Related Search:

4(1H)-Quinolinone, 8-chloro-2-[(2,4-dichlorophenyl)amino]-3-(3-methyl-1-oxobutyl)-5-nitro-

JH-RE-06

JH RE 06,DNA/RNA Synthesis,inhibit,Inhibitor,JHRE06

8-Chloro-2-((2,4-dichlorophenyl)amino)-3-(3-methylbutanoyl)-5-nitroquinolin-4(1H)-one

JH-RE-06, 10 mM in DMSO

JH-RE-06 ，S8850

1361227-90-8

C20H16Cl3N3O4