ChemicalBook > CAS DataBase List > 4(1H)-Quinolinone, 8-chloro-2-[(2,4-dichlorophenyl)amino]-3-(3-methyl-1-oxobutyl)-5-nitro-

4(1H)-Quinolinone, 8-chloro-2-[(2,4-dichlorophenyl)amino]-3-(3-methyl-1-oxobutyl)-5-nitro-

Product Name
4(1H)-Quinolinone, 8-chloro-2-[(2,4-dichlorophenyl)amino]-3-(3-methyl-1-oxobutyl)-5-nitro-
CAS No.
1361227-90-8
Chemical Name
4(1H)-Quinolinone, 8-chloro-2-[(2,4-dichlorophenyl)amino]-3-(3-methyl-1-oxobutyl)-5-nitro-
Synonyms
JH-RE-06;JH-RE-06 ，S8850;JH-RE-06, 10 mM in DMSO;JH RE 06,DNA/RNA Synthesis,inhibit,Inhibitor,JHRE06;8-Chloro-2-((2,4-dichlorophenyl)amino)-3-(3-methylbutanoyl)-5-nitroquinolin-4(1H)-one;4(1H)-Quinolinone, 8-chloro-2-[(2,4-dichlorophenyl)amino]-3-(3-methyl-1-oxobutyl)-5-nitro-
CBNumber
CB45486742
Molecular Formula
C20H16Cl3N3O4
Formula Weight
468.72
MOL File
1361227-90-8.mol
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4(1H)-Quinolinone, 8-chloro-2-[(2,4-dichlorophenyl)amino]-3-(3-methyl-1-oxobutyl)-5-nitro- Property

Boiling point:
586.9±50.0 °C(Predicted)
Density 
1.503±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO: 5 mg/mL (10.67 mM)
form 
Solid
pka
-3.78±0.70(Predicted)
color 
White to yellow
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML2993
Product name
JH-RE-06
Purity
≥98% (HPLC)
Packaging
5MG
Price
$120.65
Updated
2025/07/31
Sigma-Aldrich
Product number
SML2993
Product name
JH-RE-06
Purity
≥98% (HPLC)
Packaging
25MG
Price
$489
Updated
2025/07/31
ChemScene
Product number
CS-0099826
Product name
JH-RE-06
Purity
99.87%
Packaging
5mg
Price
$570
Updated
2021/12/16
ChemScene
Product number
CS-0099826
Product name
JH-RE-06
Purity
99.87%
Packaging
10mg
Price
$965
Updated
2021/12/16
Axon Medchem
Product number
Axon3002
Product name
JH-RE-06
Purity
99%
Packaging
5mg
Price
$159.5
Updated
2021/12/16
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4(1H)-Quinolinone, 8-chloro-2-[(2,4-dichlorophenyl)amino]-3-(3-methyl-1-oxobutyl)-5-nitro- Chemical Properties,Usage,Production

Uses

JH-RE-06-d6 is deuterium labele JH-RE-06. JH-RE-06, a potent REV1-REV7 interface inhibitor (IC50=0.78 μM; Ki=0.42 μM), targets REV1 that interacts with the REV7 subunit of POLζ. JH-RE-06 disrupts mutagenic translesion synthesis (TLS) by preventing recruitment of mutagenic POLζ. JH-RE-06 improves chemotherapy[1].

Biological Activity

JH-RE-06 is a potent and selective inhibitor of REV1-REV7 interaction th at induces REV1 dimerization blocking the REV1-REV7 interaction and POL ϲ recruitment. JH-RE-06 potently inhibits translesion synthesis (TLS) and augments cisplatin effectiveness in cultured human and mouse cell lines. It improves effectiveness of cisplatin in A375 tumor xenograft mouse model.

References

[1] Wojtaszek JL, et al. A Small Molecule Targeting Mutagenic Translesion Synthesis Improves Chemotherapy. Cell. 2019;178(1):152-159.e11. DOI:10.1016/j.cell.2019.05.028

4(1H)-Quinolinone, 8-chloro-2-[(2,4-dichlorophenyl)amino]-3-(3-methyl-1-oxobutyl)-5-nitro- Preparation Products And Raw materials

Raw materials

Preparation Products

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4(1H)-Quinolinone, 8-chloro-2-[(2,4-dichlorophenyl)amino]-3-(3-methyl-1-oxobutyl)-5-nitro- Suppliers

China 31 United States 3 Global 34
Shanghai Beckham Medical Technology Co., Ltd
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TargetMol Chemicals Inc.
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1361227-90-8, 4(1H)-Quinolinone, 8-chloro-2-[(2,4-dichlorophenyl)amino]-3-(3-methyl-1-oxobutyl)-5-nitro-Related Search:


  • 4(1H)-Quinolinone, 8-chloro-2-[(2,4-dichlorophenyl)amino]-3-(3-methyl-1-oxobutyl)-5-nitro-
  • JH-RE-06
  • JH RE 06,DNA/RNA Synthesis,inhibit,Inhibitor,JHRE06
  • 8-Chloro-2-((2,4-dichlorophenyl)amino)-3-(3-methylbutanoyl)-5-nitroquinolin-4(1H)-one
  • JH-RE-06, 10 mM in DMSO
  • JH-RE-06 ，S8850
  • 1361227-90-8
  • C20H16Cl3N3O4