3-(5-(aminomethyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione hydrochloride
- Product Name
- 3-(5-(aminomethyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione hydrochloride
- CAS No.
- 1158264-69-7
- Chemical Name
- 3-(5-(aminomethyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione hydrochloride
- Synonyms
- hydrochloride - [A81477];Lenalidomide-5-aminomethyl hydrochloride;3-[5-(Aminomethyl)-1-oxo-2-isoindolinyl]piperidine-2,6-dione Hydrochloride;3-(5-(aminomethyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione hydrochloride;3-[5-(aminomethyl)-1-oxo-2,3-dihydro-1H-isoindol-2-yl]piperidine-2,6-dione hydrochloride;3-(5-(Aminomethyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione hydrochloride , Lenalidomide-5-aminomethyl HCl
- CBNumber
- CB45708178
- Molecular Formula
- C14H16ClN3O3
- Formula Weight
- 309.75
- MOL File
- 1158264-69-7.mol
3-(5-(aminomethyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione hydrochloride Property
- storage temp.
- -20°C, stored under nitrogen, away from moisture
- solubility
- DMSO : 16.67 mg/mL (53.82 mM; ultrasonic and warming and heat to 60°C)
- form
- Solid
- color
- Off-white to light yellow
- InChI
- InChI=1S/C14H15N3O3.ClH/c15-6-8-1-2-10-9(5-8)7-17(14(10)20)11-3-4-12(18)16-13(11)19;/h1-2,5,11H,3-4,6-7,15H2,(H,16,18,19);1H
- InChIKey
- XTILEMYXOZKSFJ-UHFFFAOYSA-N
- SMILES
- O=C1C2=CC=C(CN)C=C2CN1C1CCC(=O)NC1=O.Cl
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 1P01JY9O
- Product name
- 3-(5-(aminomethyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione hydrochloride
- Purity
- 95%
- Packaging
- 100mg
- Price
- $384
- Updated
- 2021/12/16
- Product number
- 1P01JY9O
- Product name
- 3-(5-(aminomethyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione hydrochloride
- Purity
- 95%
- Packaging
- 250mg
- Price
- $760
- Updated
- 2021/12/16
- Product number
- 027683
- Product name
- 3-(5-(aminomethyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dionehydrochloride
- Packaging
- 002
- Price
- $1200
- Updated
- 2021/12/16
- Product number
- 1P01JY9O
- Product name
- 3-(5-(aminomethyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione hydrochloride
- Purity
- 95%
- Packaging
- 1g
- Price
- $1640
- Updated
- 2021/12/16
- Product number
- 027683
- Product name
- 3-(5-(aminomethyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dionehydrochloride
- Packaging
- 003
- Price
- $2700
- Updated
- 2021/12/16
3-(5-(aminomethyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione hydrochloride Chemical Properties,Usage,Production
Description
3-(5-(Aminomethyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione hydrochloride is used in the recruitment of the cereblon protein and used as a PROTAC linker.
Uses
Lenalidomide-5-aminomethyl hydrochloride is the Lenalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Lenalidomide-5-aminomethyl hydrochloride can be connected to the ligand for protein by a linker to form PROTAC[1]
IC 50
Cereblon
References
[1] Scheepstra M, et al. Bivalent Ligands for Protein Degradation in Drug Discovery. Comput Struct Biotechnol J. 2019;17:160-176. Published 2019 Jan 25. DOI:10.1016/j.csbj.2019.01.006
[2] Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985. DOI:10.7554/eLife.57277
3-(5-(aminomethyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
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