Tubulysin I

Product Name: Tubulysin I
CAS No.: 799822-10-9
Chemical Name: Tubulysin I
Synonyms: Tubulysin I;Benzenepentanoic acid, γ-[[[2-[(1R,3R)-1-(acetyloxy)-3-[[(acetyloxy)methyl][(2S,3S)-3-methyl-2-[[[(2R)-1-methyl-2-piperidinyl]carbonyl]amino]-1-oxopentyl]amino]-4-methylpentyl]-4-thiazolyl]carbonyl]amino]-4-hydroxy-α-methyl-, (αS,γR)-
CBNumber: CB45821200
Molecular Formula: C40H59N5O10S
Formula Weight: 801.99
MOL File: 799822-10-9.mol

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Tubulysin I Property

Boiling point:: 967.4±65.0 °C(Predicted)
Density: 1.222±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: Soluble in DMSO
pka: 4.52±0.23(Predicted)

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Hazard and Precautionary Statements (GHS)

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Tubulysin I Chemical Properties,Usage,Production

Uses

Tubulysin I is a highly cytotoxic anti-microtubule toxin (anti-microtubule toxins) that is synthesized as an ADC cytotoxin (ADC Cytotoxin). Tubulysin I can be isolated from the myxobacteria Archangium geophyra and Angiococcus disciformis. Tubulysin I displays extremely potent cytotoxic activity in mammalian cells, including multidrug-resistant cell lines, with IC50 values in the low nanomolar range. Tubulysin I inhibits microtubule/tubulin polymerization and leads to cell cycle arrest and apoptosis[1][2].

References

[1] Kubicek K, et al. The tubulin-bound structure of the antimitotic drug tubulysin. Angew Chem Int Ed Engl. 2010 Jun 28;49(28):4809-12. DOI:10.1002/anie.200906828
[2] Vlahov IR, et al. Acid mediated formation of an N-acyliminium ion from tubulysins: a new methodology for the synthesis of natural tubulysins and their analogs. Bioorg Med Chem Lett. 2011 Nov 15;21(22):6778-81. DOI:10.1016/j.bmcl.2011.09.041

Tubulysin I Preparation Products And Raw materials

Raw materials

Preparation Products

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Tubulysin I Suppliers

China 7 India 1 United States 2 Global 10

Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 18892239720
Fax: 010-60605840
Email: psaitong@jm-bio.com
Country: China
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Fan De(Beijing) Biotechnology Co., Ltd.

Tel: 15911056312
Email: liming@bio-fount.com
Country: China
ProdList: 9729
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TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Country: United States
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Zhejiang Huida Biotech Co., LTD

Tel: 0571-89903882 18679456698
Email: mingxinzhu@huidabiotech.com
Country: China
ProdList: 2975
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Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 15801484223;
Email: psaitong@jm-bio.com
Country: China
ProdList: 29757
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RD International Technology Co., Limited

Tel: 18024082417
Email: market@ubiochem.com
Country: China
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TargetMol Chemicals Inc.

Tel: 15002134094
Email: marketing@targetmol.cn
Country: China
ProdList: 29573
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799822-10-9, Tubulysin IRelated Search:

Tubulysin I

Benzenepentanoic acid, γ-[[[2-[(1R,3R)-1-(acetyloxy)-3-[[(acetyloxy)methyl][(2S,3S)-3-methyl-2-[[[(2R)-1-methyl-2-piperidinyl]carbonyl]amino]-1-oxopentyl]amino]-4-methylpentyl]-4-thiazolyl]carbonyl]amino]-4-hydroxy-α-methyl-, (αS,γR)-

799822-10-9

C40H59N5O10S