Boc-Val-Ala-PAB

Product Name: Boc-Val-Ala-PAB
CAS No.: 1884577-99-4
Chemical Name: Boc-Val-Ala-PAB
Synonyms: Boc-Val-Ala-PAB;L-Alaninamide, N-[(1,1-dimethylethoxy)carbonyl]-L-valyl-N-[4-(hydroxymethyl)phenyl]-;(S)-2-(Boc-amino)-N-[(S)-1-[[4-(hydroxymethyl)phenyl]amino]-1-oxo-2-propyl]-3-methylbutanamide;tert-butyl N-[(1S)-1-{[(1S)-1-[(4-(hydroxymethyl)phenyl)carbamoyl]ethyl]carbamoyl}-2-methylpropyl]carbamate;tert-butyl N-[(2S)-1-[[(2S)-1-[4-(hydroxymethyl)anilino]-1-oxopropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]carbamate;tert-Butyl ((S)-1-(((S)-1-((4-(hydroxymethyl)phenyl)amino)-1-oxopropan-2-yl)amino)-3-methyl-1-oxobutan-2-yl)carbamate;((S)-1-(((S)-1-((4-(hydroxymethyl)phenyl)amino)-1-oxypropane-2-yl)amino)-3-methyl-1-oxybutyl-2-yl)aminomacetic acidtertbutyl ester
CBNumber: CB45864430
Molecular Formula: C20H31N3O5
Formula Weight: 393.48
MOL File: 1884577-99-4.mol

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Boc-Val-Ala-PAB Property

Boiling point:: 653.7±55.0 °C(Predicted)
Density: 1.166±0.06 g/cm3(Predicted)
storage temp.: Storage temp. 2-8°C
form: Solid
pka: 11.26±0.46(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

Iris Biotech GmbH

Product number: ADC1040
Product name: Boc-Val-Ala-PAB
Packaging: 250mg
Price: $303.75
Updated: 2021/12/16

Iris Biotech GmbH

Product number: ADC1040
Product name: Boc-Val-Ala-PAB
Packaging: 1g
Price: $877.5
Updated: 2021/12/16

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Boc-Val-Ala-PAB Chemical Properties,Usage,Production

Description

Boc-Val-Ala-PAB is a cleavable ADC linker. The Val-Ala is effectively cleaved by lysosomal proteolytic enzymes while being highly stable in human plasma, making this a potentent stragy in ADC linker design. The t-butyl protected carboxyl group can be deprotected under acidic conditions.

Uses

Boc-Val-Ala-PAB is a cathepsin cleavable ADC linker that is used for making antibody-drug conjugate (ADCs)[1][2].

References

[1] HP Wilson, et al. Pyrrolobenzodiazepines and conjugates thereof: World Intellectual Property Organization, WO2016037644. 2016-03-17.
[2] HP Wilson, et al. Preparation of pyrrolobenzodiazepine dimers and their conjugates with cell binding agents, especially pyrrolobenzodiazepine dimer drug linker antibody conjugates and their use for treating proliferative diseases, particularly cancer: World Intellectual Property Organization, WO2016038383. 2016-03-17

Boc-Val-Ala-PAB Preparation Products And Raw materials

Raw materials

Preparation Products

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Boc-Val-Ala-PAB Suppliers

China 56 United States 1 Global 57

xinguokeji

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Accela ChemBio Co.,Ltd.

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Tianjin Chempharmatech Co.,Ltd.

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Bide Pharmatech Ltd.

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Shanghai Send Pharmaceutical Technology Co., Ltd.

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Shanghai Chaolan Chemical Technology Center

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Heze Development Zone chuangli Chemical Co., Ltd.

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Amatek Scientific Co. Ltd.

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Jiaxing Deyi Chemical Co., Ltd.

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Xi'an Confluore Biological Technology Co., Ltd.

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View Lastest Price from Boc-Val-Ala-PAB manufacturers

Xian confluore Biological Technology Co., Ltd.

Product: Boc-Val-Ala-PAB 1884577-99-4
Price: US $0.00/g
Min. Order: 1g
Purity: >95.00%
Supply Ability: 1g
Release date: 2024-03-29

1884577-99-4, Boc-Val-Ala-PABRelated Search:

Boc-Val-Ala-PAB

(S)-2-(Boc-amino)-N-[(S)-1-[[4-(hydroxymethyl)phenyl]amino]-1-oxo-2-propyl]-3-methylbutanamide

tert-Butyl ((S)-1-(((S)-1-((4-(hydroxymethyl)phenyl)amino)-1-oxopropan-2-yl)amino)-3-methyl-1-oxobutan-2-yl)carbamate

L-Alaninamide, N-[(1,1-dimethylethoxy)carbonyl]-L-valyl-N-[4-(hydroxymethyl)phenyl]-

tert-butyl N-[(1S)-1-{[(1S)-1-[(4-(hydroxymethyl)phenyl)carbamoyl]ethyl]carbamoyl}-2-methylpropyl]carbamate

tert-butyl N-[(2S)-1-[[(2S)-1-[4-(hydroxymethyl)anilino]-1-oxopropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]carbamate

((S)-1-(((S)-1-((4-(hydroxymethyl)phenyl)amino)-1-oxypropane-2-yl)amino)-3-methyl-1-oxybutyl-2-yl)aminomacetic acidtertbutyl ester

1884577-99-4

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