ChemicalBook > CAS DataBase List > 1 -(4-CHLOROPHENYL)-1 -PHENYLETHANOL

1 -(4-CHLOROPHENYL)-1 -PHENYLETHANOL

Product Name
1 -(4-CHLOROPHENYL)-1 -PHENYLETHANOL
CAS No.
59767-24-7
Chemical Name
1 -(4-CHLOROPHENYL)-1 -PHENYLETHANOL
Synonyms
Clemastine EP Impurity C;CleMastine FuMarate IMpurity C;Clemastine Fumarate EP Impurity C;1-(p-Chlorophenyl)-1-phenylethanol;(RS)-1-(4-Chlorophenyl)-1-phenyleth;Clemastine Impurity 3(EP Impurity C);1 -(4-CHLOROPHENYL)-1 -PHENYLETHANOL;(RS)-1-(4-Chlorophenyl)-1-phenylethanol;α-Methyl-α-phenyl-4-chlorobenzenemethanol;4-Chloro-α-methyl-α-phenylbenzenemethanol
CBNumber
CB4587596
Molecular Formula
C14H13ClO
Formula Weight
232.71
MOL File
59767-24-7.mol
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1 -(4-CHLOROPHENYL)-1 -PHENYLETHANOL Property

Boiling point:
358℃
Density 
1.189
Flash point:
170℃
storage temp. 
Sealed in dry,Room Temperature
solubility 
Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
pka
13.41±0.29(Predicted)
form 
Oil
color 
Colourless to Light Yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H319Causes serious eye irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
BP955
Product name
1-(4-Chlorophenyl)-1-phenylethanol
Purity
British Pharmacopoeia (BP) Reference Standard
Packaging
25MG
Price
$234
Updated
2025/07/31
TRC
Product number
C380475
Product name
1-(4-Chlorophenyl)-1-phenylethanol
Packaging
25mg
Price
$125
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0356566
Product name
1-(4-CHLOROPHENYL)-1-PHENYLETHANOL
Purity
95.00%
Packaging
250MG
Price
$282.45
Updated
2021/12/16
Medical Isotopes, Inc.
Product number
50359
Product name
1-(4-Chlorophenyl)-1-phenylethanol
Packaging
250mg
Price
$590
Updated
2021/12/16
AK Scientific
Product number
1918CV
Product name
1-(4-Chlorophenyl)-1-phenylethanol
Packaging
25g
Price
$722
Updated
2021/12/16
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1 -(4-CHLOROPHENYL)-1 -PHENYLETHANOL Chemical Properties,Usage,Production

Uses

1-(4-Chlorophenyl)-1-phenylethanol (Clemastine EP Impurity C) is used in the synthetic preparation of rhodium-catalyzed arylation of nitriles, ketones and imines with tetrafluoroborate or arylboronic acids

Synthesis

108-86-1

99-91-2

59767-24-7

1. A solution was prepared by dissolving bromobenzene (20.31 g, 129.35 mmol) in anhydrous tetrahydrofuran (50 mL) under nitrogen protection. 2. The above solution was added slowly and dropwise to a reaction flask containing magnesium shavings (3.88 g, 159.61 mmol), dry tetrahydrofuran (50 mL) and iodine crystals. 3. After heating and refluxing for about 2 hours, the resulting solution of Grignard reagent was cooled to about 0°C. 4. A tetrahydrofuran solution (100 mL) of 1-(4-chlorophenyl)ethanone (10.0 g, 64.69 mmol) was slowly added dropwise to the cooled Grignard reagent solution described above at 0°C. 5. After the dropwise addition was completed, the reaction mixture was stirred at room temperature for about 18 hours. 6. Upon completion of the reaction, the mixture was cooled to about 0°C and the reaction was quenched by slow addition of saturated ammonium chloride solution. 7. The organic phase was collected after standard extraction using ethyl acetate. 8. The crude product was purified by silica gel column chromatography with petroleum ether solution of 5% ethyl acetate as eluent to afford the title compound 1-(4-chlorophenyl)-1-phenylethanol as an oil (3.80 g, 25% yield). 9. The product was characterized as follows: 1H NMR (400 MHz, CDCl3) δ 1.94 (s, 3H), 2.17 (s, 1H, exchangeable with D2O), 7.23-7.42 (m, 9H). IR (membrane) υ 3414, 3061, 2978, 2927, 2859, 1597, 1489, 1449, 1394 cm-1; MS 215, 217 [(s, 1H, exchangeable with D2O)]. MS 215, 217 [(M+1)-H2O, (M+3)-H2O].

References

[1] Patent: US2009/203763, 2009, A1. Location in patent: Page/Page column 35

1 -(4-CHLOROPHENYL)-1 -PHENYLETHANOL Preparation Products And Raw materials

Raw materials

Preparation Products

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1 -(4-CHLOROPHENYL)-1 -PHENYLETHANOL Suppliers

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View Lastest Price from 1 -(4-CHLOROPHENYL)-1 -PHENYLETHANOL manufacturers

Chongqing Soarwin Technology Co., Ltd
Product
1 -(4-CHLOROPHENYL)-1 -PHENYLETHANOL 59767-24-7
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
99.99%
Supply Ability
20 tons
Release date
2025-04-11
Firsky International Trade (Wuhan) Co., Ltd
Product
1-(4-chlorophenyl)-1-phenylethanol 59767-24-7
Price
US $30.00/L
Min. Order
1L
Purity
99%
Supply Ability
20T
Release date
2023-10-08
Wuhan Han Sheng New Material Technology Co.，Ltd
Product
1 -(4-CHLOROPHENYL)-1 -PHENYLETHANOL 59767-24-7
Price
US $0.00-0.00/g
Min. Order
100g
Purity
99%
Supply Ability
20 tons
Release date
2023-07-31

59767-24-7, 1 -(4-CHLOROPHENYL)-1 -PHENYLETHANOLRelated Search:

Dicofol CHLOROPROPYLATE 3,4,5,6-TETRACHLOROFLUORESCEIN CHLOROBENZILATE Acid Red 92 2',4',5',7'-TETRABROMO-3,4,5,6-TETRACHLOROFLUORESCEIN 4,4'-DICHLORO-ALPHA-METHYLBENZHYDROL ROSE BENGAL 4,4',4''-TRICHLOROTRITYL ALCOHOL FLUORESCEIN CHLORIDE ROSE BENGAL Clemastine fumarate Fenarimol ROSE BENGAL LACTONE o,p'-dicofol 1,1-BIS(4-CHLOROPHENYL)-2-[(2-CHLOROPHENYL)SULFONYL]-1-ETHANOL 1,1-BIS(4-CHLOROPHENYL)-2-[(4-CHLOROPHENYL)SULFONYL]-1-ETHANOL 1,1-BIS(4-CHLOROPHENYL)-2-[(4-CHLOROPHENYL)SULFANYL]-1-ETHANOL

  • 1 -(4-CHLOROPHENYL)-1 -PHENYLETHANOL
  • 1-(p-Chlorophenyl)-1-phenylethanol
  • 4-Chloro-α-methyl-α-phenylbenzenemethanol
  • α-Methyl-α-phenyl-4-chlorobenzenemethanol
  • CleMastine FuMarate IMpurity C
  • Clemastine Impurity 3(EP Impurity C)
  • Clemastine EP Impurity C
  • Clemastine Fumarate EP Impurity C
  • (RS)-1-(4-Chlorophenyl)-1-phenyleth
  • Benzenemethanol, 4-chloro-α-methyl-α-phenyl-
  • 1 -(4-CHLOROPHENYL)-1 -PHENYLETHANOL ISO 9001：2015 REACH
  • 59767-24-7 1 -(4-CHLOROPHENYL)-1 -PHENYLETHANOL
  • (RS)-1-(4-Chlorophenyl)-1-phenylethanol
  • 1-(4-Chlorophenyl)-1-phenylethanol (Clemastine Impurity)
  • 59767-24-7
  • C14H13CO