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d-Epigalbacin

Product Name
d-Epigalbacin
CAS No.
84709-25-1
Chemical Name
d-Epigalbacin
Synonyms
epigalbacin;d-epigalacin;(-)-Zuonin A;d-Epigalbacin;1,3-Benzodioxole, 5,5'-[(2S,3R,4S,5S)-tetrahydro-3,4-dimethyl-2,5-furandiyl]bis-
CBNumber
CB45985179
Molecular Formula
C20H20O5
Formula Weight
340.37
MOL File
84709-25-1.mol
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d-Epigalbacin Property

Boiling point:
460.6±45.0 °C(Predicted)
Density 
1.258±0.06 g/cm3(Predicted)
storage temp. 
4°C, protect from light
form 
Solid
color 
White to off-white
InChI
InChI=1S/C20H20O5/c1-11-12(2)20(14-4-6-16-18(8-14)24-10-22-16)25-19(11)13-3-5-15-17(7-13)23-9-21-15/h3-8,11-12,19-20H,9-10H2,1-2H3/t11-,12+,19-,20-/m0/s1
InChIKey
QFUXQRHAJWXPGP-YLYZPZNOSA-N
SMILES
O1[C@H](C2=CC=C3OCOC3=C2)[C@@H](C)[C@@H](C)[C@H]1C1=CC=C2OCOC2=C1
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0119326
Product name
(-)-ZuoninA
Purity
99.84%
Packaging
1mg
Price
$200
Updated
2021/12/16
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d-Epigalbacin Chemical Properties,Usage,Production

Uses

(-)-Zuonin A (D-Epigalbacin), a naturally occurring lignin, is a potent, selective JNKs inhibitor, with IC50s of 1.7 μM, 2.9 μM and 1.74 μM for JNK1, JNK2 and JNK3, respectively[1].

Biological Activity

(-)-Zuonin A (D-Epigalbacin), a natural lignin, is a potent and selective inhibitor of JNKs with IC50 values of 1.7 μM, 2.9 μM and 1.74 μM for JNK1, JNK2 and JNK3, respectively.

in vitro

(?)-zuonin A binds the D-recruitment site (DRS) of JNK, a recruitment site utilized by substrates and other substrates to dock onto and recognize MAPKs.
(?)-zuonin A

target

JNK1

1.7 μM (IC 50 )

JNK2

2.9 μM (IC 50 )

JNK3

1.74 μM (IC 50 )

IC 50

JNK1: 1.7 μM (IC50); JNK2: 2.9 μM (IC50); JNK3: 1.74 μM (IC50)

References

[1] Tamer S. Kaoud, et al. Manipulating JNK Signaling with (?)-zuonin A. ACS Chem Biol. 2012 Nov 16; 7(11): 1873–1883. DOI:10.1021/cb300261e

d-Epigalbacin Preparation Products And Raw materials

Raw materials

Preparation Products

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d-Epigalbacin Suppliers

China 37 United States 2 Global 39
TargetMol Chemicals Inc.
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+1-781-999-5354;
Email
support@targetmol.com
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United States
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39035
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MedChemExpress
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sales@medchemexpress.com
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United States
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84709-25-1, d-EpigalbacinRelated Search:

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  • d-Epigalbacin
  • epigalbacin
  • 1,3-Benzodioxole, 5,5'-[(2S,3R,4S,5S)-tetrahydro-3,4-dimethyl-2,5-furandiyl]bis-
  • (-)-Zuonin A
  • d-epigalacin
  • 84709-25-1