ChemicalBook > CAS DataBase List > BO-264

BO-264

Product Name
BO-264
CAS No.
2408648-20-2
Chemical Name
BO-264
Synonyms
BO-264;3-(4-Methoxyphenyl)-N-(2-morpholinopyrimidin-4-yl)isoxazol-5-amine;4-Pyrimidinamine, N-[3-(4-methoxyphenyl)-5-isoxazolyl]-2-(4-morpholinyl)-;inhibit,cytotoxicity,antitumor,Fibroblast growth factor receptor,BO-264,Apoptosis,Inhibitor,TACC3,spindle,abnormalities,FGFR,ERK1/2,BO 264,DNA,phosphorylation,FGFR3-TACC3,mitotic,damage,anti-proliferative,BO264
CBNumber
CB46199294
Molecular Formula
C18H19N5O3
Formula Weight
353.38
MOL File
2408648-20-2.mol
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BO-264 Property

Boiling point:
627.9±65.0 °C(Predicted)
Density 
1.306±0.06 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
Soluble in DMSO (>25 mg/ml)
pka
6.69±0.10(Predicted)
form 
solid
color 
Off-white
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0116466
Product name
BO-264
Purity
99.63%
Packaging
10mg
Price
$220
Updated
2021/12/16
ChemScene
Product number
CS-0116466
Product name
BO-264
Purity
99.63%
Packaging
50mg
Price
$450
Updated
2021/12/16
ChemScene
Product number
CS-0116466
Product name
BO-264
Purity
99.63%
Packaging
100mg
Price
$720
Updated
2021/12/16
ChemScene
Product number
CS-0116466
Product name
BO-264
Purity
99.63%
Packaging
250mg
Price
$1300
Updated
2021/12/16
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BO-264 Chemical Properties,Usage,Production

Description

BO-264 (2408648-20-2) is a potent (IC50 = 188 nM) inhibitor of transforming acidic coiled-coil 3 (TACC3), an important protein involved in microtubule stability and centrosome integrity.1 TACC3 is frequently upregulated in a broad range of cancers. BO-264 displayed significant anticancer activity in greater than 90% of cell lines in the NCI-60 human cancer cell line panel. Active in vivo in mice injected with JIMT-1 and EMT6 breast cancer cells as well as mouse colon cancer xenografts HCT-116 and CT-26.

References

References:

BO-264 Preparation Products And Raw materials

Raw materials

Preparation Products

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BO-264 Suppliers

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2408648-20-2, BO-264Related Search:

KU57788(NU7441) Pomalidomide Dequalinium chloride NORFLUOXETINE HYDROCHLORIDE

  • BO-264
  • 4-Pyrimidinamine, N-[3-(4-methoxyphenyl)-5-isoxazolyl]-2-(4-morpholinyl)-
  • 3-(4-Methoxyphenyl)-N-(2-morpholinopyrimidin-4-yl)isoxazol-5-amine
  • inhibit,cytotoxicity,antitumor,Fibroblast growth factor receptor,BO-264,Apoptosis,Inhibitor,TACC3,spindle,abnormalities,FGFR,ERK1/2,BO 264,DNA,phosphorylation,FGFR3-TACC3,mitotic,damage,anti-proliferative,BO264
  • 2408648-20-2