5-BROMOPYRIMIDIN-4-AMINE

Product Name: 5-BROMOPYRIMIDIN-4-AMINE
CAS No.: 1439-10-7
Chemical Name: 5-BROMOPYRIMIDIN-4-AMINE
Synonyms: 5-BROMOPYRIMIDIN-4-AMINE;4-AMINO-5-BROMOPYRIMIDINE;4-Pyrimidinamine, 5-bromo-;Pyrimidine, 4-amino-5-bromo-;4-Amino-5-bromopyrimidine,98%;5-BROMOPYRIMIDIN-4-AMINE ISO 9001：2015 REACH
CBNumber: CB4663324
Molecular Formula: C4H4BrN3
Formula Weight: 174
MOL File: 1439-10-7.mol

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5-BROMOPYRIMIDIN-4-AMINE Property

Melting point:: 207-211℃
Boiling point:: 282.2±20.0 °C(Predicted)
Density: 1.844±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
pka: 3?+-.0.10(Predicted)
form: Powder
color: Pale brown
Water Solubility: Slightly soluble in water.
InChI: InChI=1S/C4H4BrN3/c5-3-1-7-2-8-4(3)6/h1-2H,(H2,6,7,8)
InChIKey: IIFAONYUCDAVGA-UHFFFAOYSA-N
SMILES: C1=NC=C(Br)C(N)=N1

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Safety

HS Code: 2933599590

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TRC

Product number: A595045
Product name: 4-Amino-5-bromopyrimidine
Packaging: 250mg
Price: $65
Updated: 2021/12/16

TRC

Product number: A595045
Product name: 4-Amino-5-bromopyrimidine
Packaging: 500mg
Price: $105
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB139355
Product name: 5-Bromopyrimidin-4-amine
Packaging: 2g
Price: $113
Updated: 2021/12/16

Matrix Scientific

Product number: 072234
Product name: 4-Amino-5-bromopyrimidine
Purity: 95+%
Packaging: 1g
Price: $104
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB139355
Product name: 5-Bromopyrimidin-4-amine
Packaging: 1g
Price: $65
Updated: 2021/12/16

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5-BROMOPYRIMIDIN-4-AMINE Chemical Properties,Usage,Production

Uses

It is an inhibitor of thymidine phosphorylase, an enzyme known to be over-expressed in several tumor types and to play a role in metastasis.

Synthesis

163133-86-6

1439-10-7

The synthesis of 4-amino-5-bromopyrimidine was carried out using the compound (CAS: 163133-86-6) as starting material according to a modified scheme of the literature method 7: 4-aminopyrimidine (1.00 g, 10.5 mmol, 1.0 eq.) was dissolved in water (20 mL) with CaCO3 (263 mg, 2.63 mmol, 0.25 eq.) followed by slow addition of bromine (Br2, 1.06 mL, 20.5 mmol, 2.0 eq.). The reaction mixture was stirred at 60 °C for 45 min, then cooled to room temperature and poured into dichloromethane (CH2Cl2, 20 mL) for layering. After separation of the organic layer, the aqueous layer was further extracted with dichloromethane (2 x 20 mL). All organic layers were combined and stored temporarily. The aqueous layer was adjusted to pH 9-10 with 20% aqueous K2CO3 to induce precipitation of the product. The precipitate was collected by filtration and dried to afford the target product 4-amino-5-bromopyrimidine (1.08 g, 6.22 mmol, 59% yield) as a light tan solid.

References

[1] Journal of Organic Chemistry, 1983, vol. 48, # 7, p. 1064 - 1069
[2] Chemical and Pharmaceutical Bulletin, 1993, vol. 41, # 1, p. 81 - 86
[3] Bioorganic and Medicinal Chemistry Letters, 2013, vol. 23, # 12, p. 3654 - 3661
[4] Bioorganic and Medicinal Chemistry Letters, 2004, vol. 14, # 21, p. 5247 - 5250
[5] European Journal of Medicinal Chemistry, 2008, vol. 43, # 6, p. 1248 - 1260

5-BROMOPYRIMIDIN-4-AMINE Preparation Products And Raw materials

Raw materials

4-Amino-2,6-dichloropyrimidine Palladium hydroxide Diethyl ether Ethyl acetate Sodium bicarbonate Bromine Acetic acid Sodium hydroxide 4-Aminopyrimidine PETROLEUM ETHER

Preparation Products

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5-BROMOPYRIMIDIN-4-AMINE Suppliers

China 135 India 3 United Kingdom 1 United States 14 Global 153

Pure Chemistry Scientific Inc.

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Alchem Pharmtech,Inc.

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Aladdin Scientific

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SynChem，Inc

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SynQuest Laboratories, Inc.

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Matrix Scientific

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3B Scientific Corporation

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Milestone PharmTech LLC

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View Lastest Price from 5-BROMOPYRIMIDIN-4-AMINE manufacturers

Dideu Industries Group Limited

Product: 5-BROMOPYRIMIDIN-4-AMINE 1439-10-7
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons Min
Release date: 2021-12-01

Career Henan Chemical Co

Product: 5-BROMOPYRIMIDIN-4-AMINE 1439-10-7
Price: US $1.00/g
Min. Order: 1g
Purity: 99.0%
Supply Ability: 100kg
Release date: 2020-01-09

1439-10-7, 5-BROMOPYRIMIDIN-4-AMINERelated Search:

5-bromo-2-chloro-4-morpholinopyrimidine 5-Bromo-2-chloro-4-(dimethylamino)pyrimidine 4-AMINO-5-BROMO-6-METHYLPYRIMIDINE Etravirine 5-BROMO-2-CHLORO-4-(1-PIPERIDINYL)PYRIMIDINE 5-BROMO-2-CHLORO-4-(1-PYRROLIDINYL)PYRIMIDINE 4-Amino-5-bromo-2-chloropyrimidine 5-BROMOPYRIMIDIN-4-AMINE 5-BROMO-2-(ISOPROPYLAMINO)PYRIMIDINE 3-Amino-2-bromopyridine 6-AMINO-5-BROMOPYRIMIDIN-2(1H)-ONE 2-BROMOPYRIMIDIN-5-AMINE 4-Amino-6-bromopyrimidine 4-Amino-3-bromopyridine 5-Amino-2-bromopyridine 5-BROMOPYRIMIDIN-2-AMINE 2-Pyrimidinamine, 4-bromo- (9CI) 5-AMINO-4-BROMOPYRIMIDINE

5-BROMOPYRIMIDIN-4-AMINE

4-AMINO-5-BROMOPYRIMIDINE

Pyrimidine, 4-amino-5-bromo-

4-Pyrimidinamine, 5-bromo-

4-Amino-5-bromopyrimidine,98%

5-BROMOPYRIMIDIN-4-AMINE ISO 9001：2015 REACH

1439-10-7

Heterocycle-Pyrimidine series

Pyrimidine series