2-METHYL-[1,8]NAPHTHYRIDINE

Uses

Product Name: 2-METHYL-[1,8]NAPHTHYRIDINE
CAS No.: 1569-16-0
Chemical Name: 2-METHYL-[1,8]NAPHTHYRIDINE
Synonyms: AKOS BBS-00006025;-1,8-naphthyridine;2-METHYL-[1,8]NAPHTHYRIDINE;1,8-Naphthyridine, 2-methyl-;2-Methyl-1,8-naphthyridine>2-Methylpyrido[2,3-b]pyridine;2-Methyl-1,8-diazanaphthalene;2-Methyl-1,8-naphthyridine,97%;2-(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-1-yl)-5,5-dimethylcyclohexane-1,3-dione
CBNumber: CB4672906
Molecular Formula: C9H8N2
Formula Weight: 144.17
MOL File: 1569-16-0.mol

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2-METHYL-[1,8]NAPHTHYRIDINE Property

Melting point:: 96-97°C
Boiling point:: 252.8±20.0 °C(Predicted)
Density: 1.141±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
form: powder to crystal
pka: 4.02±0.30(Predicted)
color: Light yellow to Brown

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 22-41
Safety Statements: 26-39
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H318Causes serious eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: ADE000831
Product name: 2-Methyl-[1,8]naphthyridine
Purity: Aldrich
Packaging: 1g
Price: $216
Updated: 2025/07/31

TCI Chemical

Product number: M2352
Product name: 2-Methyl-1,8-naphthyridine
Purity: >98.0%(GC)
Packaging: 1g
Price: $151
Updated: 2025/07/31

TRC

Product number: M330863
Product name: 2-Methyl-1,8-naphthyridine
Packaging: 50mg
Price: $45
Updated: 2021/12/16

Matrix Scientific

Product number: 018154
Product name: 2-Methyl-[1,8]naphthyridine
Packaging: 1g
Price: $44
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3H32-1-HS
Product name: 2-Methyl-[1,8]naphthyridine
Purity: 98%
Packaging: 1g
Price: $144
Updated: 2021/12/16

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2-METHYL-[1,8]NAPHTHYRIDINE Chemical Properties,Usage,Production

Uses

2-Methyl-[1,8]-naphthidine, also known as 2-methyl-1,8-naphthidine, is a pharmaceutical intermediate.

Synthesis

7521-41-7

67-64-1

1569-16-0

General procedure for the synthesis of 2-methyl-[1,8]-naphthyridine from 2-amino-3-pyridinecarboxaldehyde and acetone: 2-amino-3-pyridinecarboxaldehyde (11.10 g, 91 mmol), acetone (15.83 g, 272.9 mmol), and L-proline (11.40 g, 100.1 mmol) were dissolved in ethanol (120 mL), and the reaction was carried out under refluxing conditions with The reaction was stirred for 16 hours. After completion of the reaction, the reaction solution was cooled to room temperature and concentrated under reduced pressure. The residue was dissolved in dichloromethane (100 mL) and filtered to remove insoluble material. The filtrate was washed with deionized water (3 x 100 mL), the organic phase was dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The residue was purified by fast column chromatography with the eluent ethyl acetate:petroleum ether (1:10, v/v) to afford 2-methyl-[1,8]-naphthyridine as a white solid (13.0 g, 99% yield). Mass spectrum (ESI): m/z 145 [M + H]+.

References

[1] Bioorganic and Medicinal Chemistry Letters, 2005, vol. 15, # 10, p. 2679 - 2684
[2] Patent: WO2014/85284, 2014, A1. Location in patent: Paragraph 00227
[3] Organic and Biomolecular Chemistry, 2016, vol. 14, # 28, p. 6683 - 6686
[4] Patent: WO2018/132268, 2018, A1. Location in patent: Page/Page column 57
[5] Patent: WO2004/58761, 2004, A1. Location in patent: Page 32

2-METHYL-[1,8]NAPHTHYRIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-METHYL-[1,8]NAPHTHYRIDINE Suppliers

Americas 1 China 119 Europe 1 Germany 4 India 9 Japan 2 United Kingdom 4 United States 22 Global 162

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View Lastest Price from 2-METHYL-[1,8]NAPHTHYRIDINE manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: 2-Methyl-[1,8]-Naphthyridine 1569-16-0
Price: US $1.10-9.90/KG
Min. Order: 1KG
Purity: 99%min
Supply Ability: 100KG
Release date: 2025-08-20

Career Henan Chemical Co

Product: 2-METHYL-[1,8]NAPHTHYRIDINE 1569-16-0
Price: US $1.00/KG
Min. Order: 1KG
Purity: 90%-99.9%
Supply Ability: 500kg
Release date: 2019-07-09

1569-16-0, 2-METHYL-[1,8]NAPHTHYRIDINERelated Search:

5,6,7,8-TETRAHYDRO-6-METHYL-1,6-NAPHTHYRIDIN-3-AMINE 3-ACETYL-2-METHYL-1,6-NAPHTHYRIDINE 2-[2-(2,3-Difluorophenyl)ethyl]-N-[1-(2-methoxyethyl)-4-piperidinyl]-4-oxo-N-[[4'-(trifluoromethyl)[1,1'-biphenyl]-4-yl]methyl]-1,8-naphthyridine-1(4H)-acetamide 3-(CHLOROMETHYL)-6-(TRIFLUOROMETHYL)PYRIDINE 1-ETHYL-7-METHYL-1,8-NAPHTHYRIDINE-4-ONE-3-CARBOXYLIC ACID 7-CHLORO-2,4-BIS(TRIFLUOROMETHYL)[1,8]NAPHTHYRIDINE 4-hydroxy-7-methyl-1,8-naphthyridine-3-carboxylic acid 5,7-DIMETHYL[1,8]NAPHTHYRIDIN-2-AMINE 5-CHLORO-2-METHYL-1,8-NAPHTHYRIDINE 2-METHYL-1,6-NAPHTHYRIDINE-3-CARBOXYLATE, ETHYL ESTER,2-METHYL-1,6-NAPHTHYRIDINE-3-CARBOXYLIC ETHYL ESTER 3-Methyl-1,5-naphthyridine 4-Methyl-1,5-naphthyridine 2-METHYL-1,8-NAPHTHYRIDINE-3-CARBOXYLIC ACID MONOHYDRATE 4-METHYL-1,8-NAPHTHYRIDINE 2-METHYL-1,5-NAPHTHYRIDINE 1,4-Dihydro-1-ethyl-4-oxo-7-methyl-1,8-naphthyridine-3-carboxylic acid ethyl ester 2-METHYL-1,8-NAPHTHYRIDINE-3-CARBOXYLIC ACID 2-METHYL-1,6-NAPHTHYRIDINE-3-CARBOXYLIC ACID

AKOS BBS-00006025

2-METHYL-[1,8]NAPHTHYRIDINE

2-(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-1-yl)-5,5-dimethylcyclohexane-1,3-dione

2-Methyl-1,8-naphthyridine&gt

1,8-Naphthyridine, 2-methyl-

2-Methyl-1,8-naphthyridine,97%

-1,8-naphthyridine

2-Methyl-1,8-diazanaphthalene

2-Methylpyrido[2,3-b]pyridine

1569-16-0

Heterocycle-Pyridine series