4-BROMO-7-CHLOROQUINOLINE

Product Name: 4-BROMO-7-CHLOROQUINOLINE
CAS No.: 98519-65-4
Chemical Name: 4-BROMO-7-CHLOROQUINOLINE
Synonyms: 4-BROMO-7-CHLOROQUINOLINE;7-chloro-4-bromo-quinoline;Quinoline, 4-bromo-7-chloro-;4-Bromo-7-chloro-1-azanaphthalene
CBNumber: CB4678584
Molecular Formula: C9H5BrClN
Formula Weight: 242.5
MOL File: 98519-65-4.mol

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4-BROMO-7-CHLOROQUINOLINE Property

Melting point:: 101-103°C
Boiling point:: 331.3±22.0 °C(Predicted)
Density: 1.673
storage temp.: Sealed in dry,Room Temperature
solubility: Chloroform, DMSO, Methanol
pka: 1.81±0.27(Predicted)
form: Solid
color: Tan

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Safety

Hazard Codes: T
Risk Statements: 25-41
Safety Statements: 26-39-45
RIDADR: 2811
WGK Germany: 3
HazardClass: 6.1
PackingGroup: Ⅲ
HS Code: 2933499090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H318Causes serious eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: BBO000238
Product name: 4-Bromo-7-chloroquinoline
Purity: Aldrich
Packaging: 1g
Price: $330
Updated: 2025/07/31

TRC

Product number: B682550
Product name: 4-Bromo-7-chloroquinoline
Packaging: 1g
Price: $155
Updated: 2021/12/16

TRC

Product number: B682550
Product name: 4-Bromo-7-chloroquinoline
Packaging: 10g
Price: $1230
Updated: 2021/12/16

Matrix Scientific

Product number: 073200
Product name: 4-Bromo-7-chloroquinoline
Purity: 95+%
Packaging: 1g
Price: $270
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3H32-D-0R
Product name: 4-Bromo-7-chloroquinoline
Packaging: 1g
Price: $328
Updated: 2021/12/16

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4-BROMO-7-CHLOROQUINOLINE Chemical Properties,Usage,Production

Chemical Properties

yellow powder

Uses

4-Bromo-7-chloroquinoline is a chemical reagent in the synthesis of autophagy antitumor inhibitors, as well as antifungal agents.

Synthesis Reference(s)

The Journal of Organic Chemistry, 72, p. 2232, 2007 DOI: 10.1021/jo062168u

Synthesis

86-98-6

98519-65-4

General procedure for the synthesis of 4-bromo-7-chloroquinoline from 4,7-dichloroquinoline: 4,7-dichloroquinoline (0.3315 g, 1.674 mmol) and propionitrile (3 mL) were added in a 20 mL microwave tube, followed by the slow addition of trimethylsilyl bromide (TMS-Br, 0.434 mL, 3.35 mmol) at room temperature. Precipitation generation was observed during the reaction. The reaction tube was sealed and placed in a 100 °C oil bath for 12 hours. After completion of the reaction, the system was cooled to room temperature. The crude reaction mixture was slowly poured into pre-cooled sodium hydroxide solution (1 N, 3 mL) and the reaction tube was rinsed with an appropriate amount of water. Subsequently, the aqueous layer was extracted with ether (3 x 5 mL). All ether layers were combined, dried with anhydrous sodium sulfate (Na2SO4), filtered and concentrated under reduced pressure to afford the target product 4-bromo-7-chloroquinoline (300 mg, 1.126 mmol, 67% yield) as a yellow solid. The product was confirmed by NMR hydrogen spectrum (400 MHz, CDCl3): δ 8.70 (d, J = 4.6 Hz, 1H), 8.17 (d, J = 8.8 Hz, 1H), 8.14 (d, J = 2.0 Hz, 1H), 7.73 (d, J = 4.6 Hz, 1H), 7.63 (dd, J = 9.0, 2.0 Hz, 1H); liquid chromatography-mass spectrometry (LCMS, ESI) showed a molecular ion peak m/z of 241.9, which is consistent with the calculated value of C9H5BrClN.

References

[1] European Journal of Organic Chemistry, 2002, # 24, p. 4181 - 4184
[2] Journal of the American Chemical Society, 1959, vol. 81, p. 3984,3986
[3] Patent: WO2017/59085, 2017, A1. Location in patent: Page/Page column 224; 225

4-BROMO-7-CHLOROQUINOLINE Preparation Products And Raw materials

Raw materials

4,7-Dichloroquinoline Hydrogen bromide Benzene PETROLEUM ETHER Sodium carbonate

Preparation Products

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4-BROMO-7-CHLOROQUINOLINE Suppliers

China 52 Germany 1 India 2 United Kingdom 3 United States 12 Global 70

Alchem Pharmtech,Inc.

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Matrix Scientific

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International Laboratory Limited

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ECA International Corporation

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98519-65-4, 4-BROMO-7-CHLOROQUINOLINERelated Search:

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4-BROMO-7-CHLOROQUINOLINE

4-Bromo-7-chloro-1-azanaphthalene

7-chloro-4-bromo-quinoline

Quinoline, 4-bromo-7-chloro-

98519-65-4