ChemicalBook > CAS DataBase List > 3-BENZYL-3-AZABICYCLO[3.2.1]OCTAN-8-ONE
3-BENZYL-3-AZABICYCLO[3.2.1]OCTAN-8-ONE
- Product Name
- 3-BENZYL-3-AZABICYCLO[3.2.1]OCTAN-8-ONE
- CAS No.
- 83507-33-9
- Chemical Name
- 3-BENZYL-3-AZABICYCLO[3.2.1]OCTAN-8-ONE
- Synonyms
- (1R,5S)-3-benzyl-3-azabicyclo[3.2.1]octan-8-one;3-Benzyl-3-azabicyclo[3.2...;4-(Boc-ami)-3,6-dichloropyridazine;3-Benzyl-3-azabicylo[3.2.1]octan-8-one;3-BENZYL-3-AZABICYCLO[3.2.1]OCTAN-8-ONE;3-(phenylmethyl)-3-Azabicyclo[3.2.1]octan-8-one;3-Azabicyclo[3.2.1]octan-8-one, 3-(phenylMethyl)-
- CBNumber
- CB4681553
- Molecular Formula
- C14H17NO
- Formula Weight
- 215.29
- MOL File
- 83507-33-9.mol
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3-BENZYL-3-AZABICYCLO[3.2.1]OCTAN-8-ONE Property
- Boiling point:
- 342.9±22.0 °C(Predicted)
- Density
- 1.140±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- 7.08±0.20(Predicted)
- Appearance
- Off-white to yellow Solid
- InChI
- InChI=1S/C14H17NO/c16-14-12-6-7-13(14)10-15(9-12)8-11-4-2-1-3-5-11/h1-5,12-13H,6-10H2
- InChIKey
- DCDAOVIVXGHHHU-UHFFFAOYSA-N
- SMILES
- C12C(=O)C(CC1)CN(CC1=CC=CC=C1)C2
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
SynQuest Laboratories
- Product number
- 4H56-1-827
- Product name
- 3-Benzyl-3-azabicyclo[3.2.1]octan-8-one
- Purity
- 97.0%
- Packaging
- 250mg
- Price
- $190
- Updated
- 2021/12/16
SynQuest Laboratories
- Product number
- 4H56-1-827
- Product name
- 3-Benzyl-3-azabicyclo[3.2.1]octan-8-one
- Purity
- 97.0%
- Packaging
- 1g
- Price
- $490
- Updated
- 2021/12/16
Matrix Scientific
- Product number
- 122235
- Product name
- 3-Benzyl-3-azabicyclo[3.2.1]octan-8-one
- Purity
- 97.0%
- Packaging
- 1g
- Price
- $528
- Updated
- 2021/12/16
Ambeed
- Product number
- A190701
- Product name
- 3-Benzyl-3-azabicyclo[3.2.1]octan-8-one
- Purity
- 97%
- Packaging
- 100mg
- Price
- $16
- Updated
- 2021/12/16
Ambeed
- Product number
- A190701
- Product name
- 3-Benzyl-3-azabicyclo[3.2.1]octan-8-one
- Purity
- 97%
- Packaging
- 250mg
- Price
- $22
- Updated
- 2021/12/16
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3-BENZYL-3-AZABICYCLO[3.2.1]OCTAN-8-ONE Chemical Properties,Usage,Production
Synthesis
50-00-0
120-92-3
100-46-9
83507-33-9
General procedure for the synthesis of 3-benzyl-3-azabicyclo[3.2.1]octan-8-one (Intermediate I-32) from formaldehyde, cyclopentanone, and benzylamine: In a 2L round-bottomed flask equipped with a condenser tube and nitrogen introduction tube, benzylamine (127 g, 1.2 mol, 1.0 equiv.) and methanol (800 mL) were added, followed by the slow dropwise addition of glacial acetic acid (127 g, 1.2 mol, 1.0 equiv). Intermediate I-31 (100 g, 1.2 mol, 1.0 eq.) and paraformaldehyde (107 g, 3.6 mol, 3.0 eq.) were then added. The reaction mixture was stirred at 80 °C for 3 hours and then continued at room temperature for 18 hours. Upon completion of the reaction, the excess solvent was removed by evaporation and the residue was diluted with ethyl acetate and solid sodium bisulfite (104 g) was added. The crude reaction mixture was continued to be stirred for 1.5 hours and subsequently extracted with ethyl acetate. The organic layers were combined, dried with anhydrous Na2SO4, filtered to remove solids and the filtrate was concentrated by evaporation. The crude product was purified by silica gel column chromatography to afford intermediate I-32 (47.2 g, 18% yield) as a yellow oil.1H-NMR (400 MHz, CDCl3) δ: 7.35 (m, 4H), 7.26 (m, 1H), 3.59 (s, 2H), 2.93 (m, 2H), 2.39 (d, J=10.8 Hz, 2H). 2.50 (m, 2H), 1.93 (m, 2H), 1.81 (m, 2H).MS (ESI): m/z 216.1 (M+H+).
References
[1] Patent: US2011/65694, 2011, A1. Location in patent: Page/Page column 64
[2] Journal of Medicinal Chemistry, 1994, vol. 37, # 18, p. 2831 - 2840
[3] Patent: US2009/12116, 2009, A1. Location in patent: Page/Page column 18
3-BENZYL-3-AZABICYCLO[3.2.1]OCTAN-8-ONE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-BENZYL-3-AZABICYCLO[3.2.1]OCTAN-8-ONE manufacturers
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
- Product
- 3-Benzyl-3-azabicyclo[3.2.1]octan-8-one 83507-33-9
- Price
- US $2.00-6.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2025-08-05
Shaanxi Dideu New Materials Co. Ltd
- Product
- 3-BENZYL-3-AZABICYCLO[3.2.1]OCTAN-8-ONE 83507-33-9
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1000kg
- Release date
- 2025-06-28
Zhuozhou Wenxi import and Export Co., Ltd
- Product
- 3-BENZYL-3-AZABICYCLO[3.2.1]OCTAN-8-ONE 83507-33-9
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-06-26
83507-33-9, 3-BENZYL-3-AZABICYCLO[3.2.1]OCTAN-8-ONERelated Search:
8-BENZYL-8-AZABICYCLO[3.2.1]OCTAN-3-ONE OXIME
(1R,5R)-6β-Acetoxy-8-benzyl-8-azabicyclo[3.2.1]octan-3-one
8-BENZYL-8-AZABICYCLO[3.2.1]OCTAN-3-ONE
3-BENZYL-3-AZABICYCLO[3.2.1]OCTAN-8-ONE
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