N-Benzyltropinone

Product Name: N-Benzyltropinone
CAS No.: 28957-72-4
Chemical Name: N-Benzyltropinone
Synonyms: 8-BENZYL-8-AZABICYCLO[3.2.1]OCTAN-3-ONE;N-benzyltropinone;N-BENZYLNORTROPINONE;N-Benzyltropinone,96%;N-Benzyl-3-nortropinone;8-Benzyl-3-nortropanone;8-BENZYLNORTROPAN-3-ONE;N-Benzylnortropinone >N-Benzyltropinone,96%(TLC);8-Benzyl-8-azabicyclo[3.2...
CBNumber: CB6242602
Molecular Formula: C14H17NO
Formula Weight: 215.29
MOL File: 28957-72-4.mol

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N-Benzyltropinone Property

Melting point:: 28-29°C
Boiling point:: 134-137°C/0.4 mm
Density: 1.140±0.06 g/cm3(Predicted)
refractive index: 1.556
storage temp.: Sealed in dry,Room Temperature
solubility: Chloroform, Dichloromethane, Methanol
form: Solid
pka: 7.98±0.20(Predicted)
color: Off-White to Pale Yellow
InChI: InChI=1S/C14H17NO/c16-14-8-12-6-7-13(9-14)15(12)10-11-4-2-1-3-5-11/h1-5,12-13H,6-10H2
InChIKey: RSUHKGOVXMXCND-UHFFFAOYSA-N
SMILES: C12N(CC3=CC=CC=C3)C(CC1)CC(=O)C2
CAS DataBase Reference: 28957-72-4(CAS DataBase Reference)

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Safety

Hazard Codes: C
Risk Statements: 34
Safety Statements: 23-26-36/37/39-45
RIDADR: UN1760
HazardClass: 8
HS Code: 29299090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical

Product number: B4058
Product name: N-Benzylnortropinone
Purity: >95.0%(GC)(T)
Packaging: 1g
Price: $31
Updated: 2025/07/31

TCI Chemical

Product number: B4058
Product name: N-Benzylnortropinone
Purity: >95.0%(GC)(T)
Packaging: 5g
Price: $78
Updated: 2025/07/31

Usbiological

Product number: 003489
Product name: 3-Benzyl-3,8-diazabicyclo[3.2.1]octane
Packaging: 250mg
Price: $446
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB18303
Product name: N-Benzyl nortropinone
Packaging: 100g
Price: $600
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CCH0040664
Product name: 8-BENZYL-8-AZABICYCLO[3.2.1]OCTAN-3-ONE
Purity: 95.00%
Packaging: 1G
Price: $659
Updated: 2021/12/16

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N-Benzyltropinone Chemical Properties,Usage,Production

Chemical Properties

Off-White to Pale Yellow Low-Melting Solid

Uses

An intermediate for the preparation of β-Cocaine, opioid receptor antagonists, and CCR-5 receptor antagonists

Synthesis

542-05-2

100-46-9

28957-72-4

1. To a non-homogeneous solution of 2,5-dimethoxytetrahydrofuran (82.2 g, 0.622 mol) in water (170 mL) was slowly added concentrated hydrochloric acid (30 mL) under stirring conditions. 2. In another flask, benzylamine (100 g, 0.933 mol) was dissolved in water (350 mL), cooled to 0 °C (ice bath) and concentrated hydrochloric acid (92 mL) was added slowly. 3. The 2,5-dimethoxytetrahydrofuran solution was stirred for 20 minutes and diluted with water (250 mL), followed by the sequential addition of the benzylamine solution, an aqueous (400 mL) solution of 1,3-acetone dicarboxylic acid (100 g, 0.684 mol), and an aqueous (200 mL) solution of sodium hydrogensulphate (44 g, 0.31 mol). 4. the pH of the reaction mixture was adjusted from 1 to about 4.5 using a 40% NaOH solution. 5. The resulting cloudy light yellow solution was stirred overnight. 6. The solution was acidified from pH 7.5 to 3 with 50% hydrochloric acid, heated to 85°C and stirred for 2 hours. 7. After cooling to room temperature, the solution was alkalized to pH 12 with 40% NaOH solution and extracted with dichloromethane (3 x 500 mL). 8. The organic layers were combined, washed with brine, dried over anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to give the title intermediate as a viscous brown oil (~95% purity based on HPLC analysis). 9. The structure of the product was confirmed by 1H-NMR (CDCl3) and mass spectrometry ([M+H]+ C14H17NO calculated value 216.14; measured value 216.0).

References

[1] Patent: US2006/135764, 2006, A1. Location in patent: Page/Page column 22-23
[2] Patent: US2006/100426, 2006, A1. Location in patent: Page/Page column 18
[3] Patent: US2006/199839, 2006, A1. Location in patent: Page/Page column 23
[4] Patent: US2007/167442, 2007, A1. Location in patent: Page/Page column 40
[5] Patent: US2007/219278, 2007, A1. Location in patent: Page/Page column 15

N-Benzyltropinone Preparation Products And Raw materials

Raw materials

Preparation Products

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N-Benzyltropinone Suppliers

Americas 1 Belgium 1 Canada 1 China 185 Europe 1 Germany 2 India 3 Japan 1 United Kingdom 8 United States 25 Global 228

Beijing Mediking Biopharm Co., Ltd

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3B Pharmachem (Wuhan) International Co.,Ltd.

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TCI (Shanghai) Development Co., Ltd.

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Suzhou Chireach Biomedical Technology Co., Ltd.

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Energy Chemical

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Capot Chemical Co., Ltd

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Beijing Ouhe Technology Co., Ltd

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Pure Chemistry Scientific Inc.

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View Lastest Price from N-Benzyltropinone manufacturers

Hebei Yanxi Chemical Co., Ltd.

Product: N-Benzyltropinone 28957-72-4
Price: US $0.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 20tons
Release date: 2023-10-08

Shaanxi Dideu New Materials Co. Ltd

Product: N-Benzyltropinone 28957-72-4
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10000KGS
Release date: 2025-03-02

Beijing Mediking Biopharm Co., Ltd

Product: N-Benzylnortropinone 28957-72-4
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 2 t
Release date: 2023-11-01

28957-72-4, N-BenzyltropinoneRelated Search:

Laurocapram Tolperisone hydrochloride BENZYL GLYCIDYL ETHER Benzyltriethylammonium chloride Benzyl acetate N,N-Dimethylbenzylamine Benzyl bromide Benzyl chloride Benzyl benzoate Benzyltrimethylammonium chloride Tropinone N-Methyl-2-pyrrolidone Diltiazem hydrochloride Benzyl alcohol Benzoyl peroxide Benzyl Cycloheptanone Nortropan-3-one

3-BENZYL-3,8-DIAZABICYCLO[3.2.1]OCTANE

N-Benzyltropinone,96%

3-benzyl-3-azedicyclo(3,2,1)octan-8-one

8-Benzyl-8-azabicyclo[3.2.1]octane-3-one

N-Benzyl-3-nortropinone

(1R,5S)-8-Benzyl-8-azabicyclo[3.2.1]octan-3-one, >95%

8-Benzyl-8-azabicyclo[3.2...

8-Benzyl-1αH,5αH-nortropan-3-one

8-Benzyl-3-nortropanone

N-BENZYLNORTROPINONE

8-(Phenylmethyl)-8-azabicyclo[3.2.1]octan-3-one

8-AZA-8-BENZYLBICYCLO[3,2,1]OCTAN-3-ONE

8-BENZYLNORTROPAN-3-ONE

8-BENZYL-8-AZABICYCLO[3.2.1]OCTAN-3-ONE

8-Aza-8-benzylbicyclo[3,2,1]octan-3-one,8-Benzylnortropan-3-one

N-Benzyltropinone,96%(TLC)

N-benzyltropinone

N-Benzylnortropinone &gt

N-Benzyl-8-azabicyclo[3.2.1]octan-3-one

28957-72-4

28975-72-4

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