N1-(4-ACETYL-3-HYDROXYPHENYL)ACETAMIDE
- Product Name
- N1-(4-ACETYL-3-HYDROXYPHENYL)ACETAMIDE
- CAS No.
- 40547-58-8
- Chemical Name
- N1-(4-ACETYL-3-HYDROXYPHENYL)ACETAMIDE
- Synonyms
- N-(4-Acetyl-3-hydroxyphenyl);4'-ACETAMIDO-2'-HYDROXYACETOPHENONE;N-(4-ACETYL-3-HYDROXYPHENYL)ACETAMIDE;N1-(4-ACETYL-3-HYDROXYPHENYL)ACETAMIDE;AcetaMide, N-(4-acetyl-3-hydroxyphenyl)-;N1-(4-Acetyl-3-hydroxyphenyl)acetamide, Tech.;JR-8565, 4'-Acetamido-2'-hydroxyacetophenone, 97%
- CBNumber
- CB4684756
- Molecular Formula
- C10H11NO3
- Formula Weight
- 193.2
- MOL File
- 40547-58-8.mol
N1-(4-ACETYL-3-HYDROXYPHENYL)ACETAMIDE Property
- Melting point:
- 141-142℃
- Boiling point:
- 419.0±35.0 °C(Predicted)
- Density
- 1.267
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 9.70±0.10(Predicted)
- Appearance
- Light brown to off-white Solid
Safety
- Risk Statements
- 22-36/37/38
- Safety Statements
- 22-26-36/37/39
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- N497140
- Product name
- N-(4-Acetyl-3-hydroxyphenyl)acetamide
- Packaging
- 100mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- N497140
- Product name
- N-(4-Acetyl-3-hydroxyphenyl)acetamide
- Packaging
- 1g
- Price
- $310
- Updated
- 2021/12/16
- Product number
- Y9028
- Product name
- N1-(4-Acetyl-3-hydroxyphenyl)acetamide
- Packaging
- 5g
- Price
- $315
- Updated
- 2021/12/16
- Product number
- 084493
- Product name
- N-(4-Acetyl-3-hydroxyphenyl)acetamide
- Purity
- 97%
- Packaging
- 1g
- Price
- $277
- Updated
- 2021/12/16
- Product number
- FA54242
- Product name
- 4'-Acetamido-2'-hydroxyacetophenone
- Packaging
- 1g
- Price
- $295.2
- Updated
- 2021/12/16
N1-(4-ACETYL-3-HYDROXYPHENYL)ACETAMIDE Chemical Properties,Usage,Production
Synthesis
75-36-5
588-16-9
40547-58-8
Step 2: Preparation of 4-acetamido-2-hydroxyacetophenone N-(4-acetyl-3-hydroxyphenyl)acetamide was prepared based on the improved method of Elliott, J.M. et al. (J. Med. Chem., 1992, 35, 3973-3976): over 20 min, aluminum chloride (27 g, 206 mmol) was added batchwise to mechanically stirred 3'-methoxyacetanilide (10 g, 60.5 mmol), acetyl chloride (12.5 mL, 175.6 mmol) and dichloromethane (25 mL) mixture. Upon completion of the reaction, all dichloromethane was removed by distillation and the resulting viscous mixture was left to heat at 80°C for 3.5 hours. Subsequently, chlorobenzene (60 mL) was added and the mixture was heated to reflux (132°C) and stirred under reflux conditions for 1 hour. The reaction mixture was cooled to 0°C and crushed ice was slowly added while stirring. The resulting solid product was collected by filtration and purified by silica gel column chromatography to afford N-(4-acetyl-3-hydroxyphenyl)acetamide 7.34 g (63% yield). 1H NMR (400 MHz, DMSO-d6): δ 12.31 (s, 1H), 10.26 (s, 1H), 7.83 (d, J = 8.8 Hz, 1H), 7.34 (d, J = 1.8 Hz, 1H), 7.05 (dd, J = 8.8, 1.8 Hz, 1H), 2.56 (s, 3H), 2.08 (s, 3H) . MS-APCI (m/z +): 194 (M + 1).
References
[1] Patent: WO2007/88438, 2007, A2. Location in patent: Page/Page column 17
[2] Journal of the Chemical Society, 1958, p. 146,149
[3] Journal of the Chemical Society, 1931, p. 2388,2406
[4] Bulletin de la Societe Chimique de France, 1952, p. 639
[5] Patent: US5622989, 1997, A
N1-(4-ACETYL-3-HYDROXYPHENYL)ACETAMIDE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from N1-(4-ACETYL-3-HYDROXYPHENYL)ACETAMIDE manufacturers
- Product
- N1-(4-ACETYL-3-HYDROXYPHENYL)ACETAMIDE 40547-58-8
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-18