N1-(3-ACETYL-4-HYDROXYPHENYL)ACETAMIDE

Product Name: N1-(3-ACETYL-4-HYDROXYPHENYL)ACETAMIDE
CAS No.: 7298-67-1
Chemical Name: N1-(3-ACETYL-4-HYDROXYPHENYL)ACETAMIDE
Synonyms: N-(3-AcetyL;3'-Acetyl-4'-hydroxyacetanilide;5'-Acetamido-2'-hydroxyacetophenone;5'-Acetamido-2'-hydroxypropiophenone;5'-AcetylaMino-2'-hydroxyacetophenone;N-(3-acetyl-4-hydroxyphenyl)acetamide;5'-AcetylaMino-2'- hydroxyacetophenone;N1-(3-ACETYL-4-HYDROXYPHENYL)ACETAMIDE;5'-Acetamido-2'-hydroxyacetophenone >Acetamide, N-(3-acetyl-4-hydroxyphenyl)-
CBNumber: CB8102014
Molecular Formula: C10H11NO3
Formula Weight: 193.2
MOL File: 7298-67-1.mol

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N1-(3-ACETYL-4-HYDROXYPHENYL)ACETAMIDE Property

Melting point:: 167-168°C
Boiling point:: 414.4±35.0 °C(Predicted)
Density: 1.267±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
solubility: DMSO (Slightly), Methanol (Slightly)
form: Solid
pka: 10.11±0.18(Predicted)
color: Light Yellow

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 22-36/37/38
Safety Statements: 22-26-36/37/39
HS Code: 2924297099

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TCI Chemical

Product number: A2698
Product name: 5'-Acetamido-2'-hydroxyacetophenone
Purity: >98.0%(HPLC)(T)
Packaging: 1g
Price: $54
Updated: 2025/07/31

TCI Chemical

Product number: A2698
Product name: 5'-Acetamido-2'-hydroxyacetophenone
Purity: >98.0%(HPLC)(T)
Packaging: 5g
Price: $183
Updated: 2025/07/31

TRC

Product number: A178970
Product name: N-(3-Acetyl-4-hydroxyphenyl)acetamide
Packaging: 250mg
Price: $55
Updated: 2021/12/16

TRC

Product number: A178970
Product name: N-(3-Acetyl-4-hydroxyphenyl)acetamide
Packaging: 100mg
Price: $45
Updated: 2021/12/16

AK Scientific

Product number: Y9932
Product name: N1-(3-Acetyl-4-hydroxyphenyl)acetamide
Packaging: 1g
Price: $64
Updated: 2021/12/16

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N1-(3-ACETYL-4-HYDROXYPHENYL)ACETAMIDE Chemical Properties,Usage,Production

Uses

N-(3-Acetyl-4-hydroxyphenyl)acetamide is a useful synthetic intermediate in the synthesis of rac Diacetolol (D305200); the principal metabolite of Acebutolol (A123800) with less β-adrenoceptor blocking potency but greater cardioselectivity (atrial relative to tracheal tissue).

Synthesis

51-66-1

75-36-5

7298-67-1

General procedure for the synthesis of 2-hydroxy-5-acetamidoacetophenone from 4-methoxyacetanilide and acetyl chloride: acetyl chloride (25 mL, 0.352 mol) was slowly added dropwise to a stirred suspension of 4-methoxyacetanilide (20 g, 0.121 mol) in carbon disulfide (50 mL). Anhydrous aluminum chloride (55 g, 0.412 mol) was then added in batches. The reaction mixture was heated and stirred at 80-90°C for 90 minutes. After completion of the reaction, the solvent was removed by distillation under reduced pressure. The residue was carefully poured into a mixture of crushed ice and water. The precipitated solid was collected by filtration and washed well with water. The crude product was dissolved in 5% (w/v) aqueous sodium hydroxide solution and the solution was filtered through Celite. The filtrate was acidified to pH 1 with concentrated hydrochloric acid to precipitate 2-hydroxy-5-acetamidoacetophenone. The product was collected by filtration, washed with water and dried to give a white solid (21.05 g, 90% yield): melting point 162-164°C; IR (KBr)ν: 3452 cm-1 (O-H stretching vibration), 1657 cm-1 (C=O stretching vibration); 1H NMR (DMSO-d6, 500 MHz): δ 2.02 (s, 3H, - NHCOCH3), 2.58 (s, 3H, -COCH3), 6.90 (d, 1H, 5-H), 7.65 (dd, 1H, 6-H), 8.06 (s, 1H, 2-H), 9.89 (s, 1H, -NHCOCH3), 11.54 (s, 1H, -OH). Elemental analysis (C10H11NO3) calculated values: C, 62.17; H, 5.74; N, 7.25. measured values: C, 62.35; H, 5.82; N, 7.19.

References

[1] Bioorganic and Medicinal Chemistry, 2011, vol. 19, # 13, p. 3919 - 3928
[2] Patent: WO2012/107262, 2012, A1. Location in patent: Page/Page column 29
[3] Journal of Organic Chemistry, 1995, vol. 60, # 14, p. 4324 - 4330
[4] Journal of Medicinal Chemistry, 1992, vol. 35, # 21, p. 3973 - 3976
[5] Bioorganic and Medicinal Chemistry, 2004, vol. 12, # 9, p. 2079 - 2098

N1-(3-ACETYL-4-HYDROXYPHENYL)ACETAMIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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N1-(3-ACETYL-4-HYDROXYPHENYL)ACETAMIDE Suppliers

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View Lastest Price from N1-(3-ACETYL-4-HYDROXYPHENYL)ACETAMIDE manufacturers

Career Henan Chemical Co

Product: N1-(3-ACETYL-4-HYDROXYPHENYL)ACETAMIDE 7298-67-1
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 10 tons
Release date: 2020-01-10

7298-67-1, N1-(3-ACETYL-4-HYDROXYPHENYL)ACETAMIDERelated Search:

N1-(4-ACETYL-3-HYDROXYPHENYL)ACETAMIDE,N-(4-ACETYL-3-HYDROXYPHENYL)ACETAMIDE N-(4-ACETYL-2-HYDROXYPHENYL)ACETAMIDE Acebutolol hydrochloride Acebutolol-D5 2-Acetyl-4-butyramidophenol N1-(3-ACETYL-2-HYDROXY-4-METHOXYPHENYL)ACETAMIDE N-[3-ACETYL-4-[2-HYDROXY-3-[(1-METHYLETHYL)AMINO]PROPOXY]PHENYL]BUTANAMIDE N-[4-HYDROXY-3-(3-PHENYL-ACRYLOYL)-PHENYL]-ACETAMIDE N-[3-acetyl-4-(oxiranylmethoxy)phenyl]butyramide 6-ACETYLAMINO-4-OXO-2-SPIRO(N-BOC-PIPERIDINE-4-YL)-BENZOPYRAN 6-ACETAMIDOCHROMAN-4-ONE N-(3-ACETYL-4-METHOXYPHENYL)ETHANAMIDE 1-ACETAMIDO-4-HYDROXYANTHRAQUINONE Diacetolol N1-(3-ACETYL-4-HYDROXYPHENYL)ACETAMIDE

5'-AcetylaMino-2'-hydroxyacetophenone

N1-(3-ACETYL-4-HYDROXYPHENYL)ACETAMIDE

N-(3-acetyl-4-hydroxyphenyl)acetamide

5'-Acetamido-2'-hydroxyacetophenone &gt

N-(3-AcetyL

5'-Acetamido-2'-hydroxypropiophenone

Acetamide, N-(3-acetyl-4-hydroxyphenyl)-

3'-Acetyl-4'-hydroxyacetanilide

5'-Acetamido-2'-hydroxyacetophenone

5'-AcetylaMino-2'- hydroxyacetophenone

7298-67-1

Phenyls & Phenyl-Het