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MINAPRINE DIHYDROCHLORIDE

Product Name
MINAPRINE DIHYDROCHLORIDE
CAS No.
25905-77-5
Chemical Name
MINAPRINE DIHYDROCHLORIDE
Synonyms
minaprine;TS-370;Cantor;minaprin;Minaprina;Minaprinum;Minaprin diHCl;Minaprine 2HCl;MINAPRINE HYDROCHLORIDE;MINAPRIN DIHYDROCHLORIDE
CBNumber
CB4686336
Molecular Formula
C17H22N4O
Formula Weight
298.38
MOL File
25905-77-5.mol
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MINAPRINE DIHYDROCHLORIDE Property

Melting point:
122°
Boiling point:
531.2±50.0 °C(Predicted)
Density 
1.156±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO : ≥ 35 mg/mL (117.30 mM)
pka
6.80±0.10(Predicted)
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Safety

Hazard Codes 
Xn
Risk Statements 
22
Safety Statements 
36
WGK Germany 
3
RTECS 
QE3477830
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
M3157
Product name
Minaprine dihydrochloride
Purity
analytical standard
Packaging
1g
Price
$61.4
Updated
2022/05/15
TRC
Product number
M345203
Product name
Minaprine
Packaging
2.5g
Price
$85
Updated
2021/12/16
Usbiological
Product number
456242
Product name
Minaprine
Packaging
1g
Price
$305
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0009128
Product name
MINAPRINE
Purity
95.00%
Packaging
1G
Price
$654.16
Updated
2021/12/16
CSNpharm
Product number
CSN18166
Product name
Minaprine
Packaging
25mg
Price
$35
Updated
2021/12/16
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MINAPRINE DIHYDROCHLORIDE Chemical Properties,Usage,Production

Originator

Cantor,Clin Midy,France,1979

Uses

Minaprine is a central nervous system (CNS) drug through the use of analog synthesis and CYP2D6 enzyme kinetic analyses.

Uses

muscle relaxant (skeletal)

Definition

ChEBI: Minaprine is a member of pyridazines, a secondary amine and a member of morpholines. It has a role as an antidepressant, a serotonin uptake inhibitor, a dopamine uptake inhibitor, a cholinergic drug and an antiparkinson drug.

Manufacturing Process

(a) Preparation of the free base: A mixture comprising 0.1 mol (20.4 g) of 3-chloro-4-methyl-6-phenylpyridazine and 0.2 mol (26.2 g) of N-(2-aminoethyl)-morpholine in 100 ml of n-butanol, with a pinch of copper powder, was heatedunder reflux for 12 hours. At the end of this time, the hot solution was pouredinto 200 ml of cold water. The resulting mixture was filtered through asintered glass filter and the precipitate washed with ether. The filtrate and theether washings were placed in a separating funnel and extracted with two 150ml portions of ether. The ethereal layer was then extracted with about 250 mlof N sulfuric acid.
The acid solution was made alkaline with a 10% aqueous solution of sodiumcarbonate, and left to crystallize overnight.
The solution was filtered, yielding the colorless needles which wererecrystallized from isopropanol. The yield was 15 g (53%).
(b) Preparation of the hydrochloride: The base was dissolved in the smallestamount possible of anhydrous acetone. Double that volume of anhydrousether was added, and a stream of hydrogen chloride gas was passed throughthe solution. The hydrochloride salt obtained was recrystallized from absolutealcohol. The yield after recrystallization was 17 g (90%).

brand name

Cantor (Sanofi).

Therapeutic Function

Antidepressant

MINAPRINE DIHYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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MINAPRINE DIHYDROCHLORIDE Suppliers

LGM Pharma
Tel
1-(800)-881-8210
Fax
615-250-9817
Email
inquiries@lgmpharma.com
Country
United States
ProdList
2123
Advantage
70
Beijing HuaMeiHuLiBiological Chemical
Tel
010-56205725
Fax
010-65763397
Email
waley188@sohu.com
Country
China
ProdList
12335
Advantage
58
Shanghai T&W Pharmaceutical Co., Ltd.
Tel
+86 21 61551611
Fax
+86 21 50676805
Country
China
ProdList
9891
Advantage
58
Haoyuan Chemexpress Co., Ltd.
Tel
021-58950125
Fax
(86) 21-58955996
Email
info@chemexpress.com
Country
China
ProdList
7552
Advantage
61
MedChemexpress LLC
Tel
021-58955995
Fax
609-228-5909
Email
sales@medchemexpress.cn
Country
United States
ProdList
4861
Advantage
58
Guangzhou Isun Pharmaceutical Co., Ltd
Tel
020-39119399 18927568969
Fax
020-39119999
Email
isunpharm@qq.com
Country
China
ProdList
4674
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55
Musechem
Tel
+1-800-259-7612
Fax
+1-800-259-7612
Email
info@musechem.com
Country
United States
ProdList
4660
Advantage
60
Angel Pharmatech, Ltd.
Tel
17317130613
Fax
QQ3358272972
Email
3358272972@qq.com
Country
China
ProdList
3253
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Hangzhou Synstar pharmaceutical Technology CO.,Ltd
Tel
0571-85361029
Fax
0571-85361029
Email
synstar518@163.com
Country
China
ProdList
1990
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32161
Advantage
58

25905-77-5, MINAPRINE DIHYDROCHLORIDERelated Search:


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  • n-(4-methyl-6-phenyl-3-pyridazinyl)-4-morpholineethanamine
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  • N-(4-Methyl-6-phenylpyridazin-3-yl)-4-morpholineethanamine
  • TS-370
  • N-[4-METHYL-6-PHENYL-3-PYRIDAZINYL]-4-MORPHOLINEETHANAMINE DIHYDROCHLORIDE
  • MINAPRIN DIHYDROCHLORIDE
  • MINAPRINE DIHYDROCHLORIDE
  • MINAPRINE HYDROCHLORIDE
  • Minaprine 2HCl
  • minaprine
  • Cantor
  • Minaprina
  • Minaprinum
  • 4-Morpholineethanamine, N-(4-methyl-6-phenyl-3-pyridazinyl)-
  • 4-Methyl-N-(2-morpholinoethyl)-6-phenylpyridazin-3-amine , Minaprine
  • 25905-77-5
  • C17H22N4O
  • C17H22N4O2HCl
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