MINAPRINE DIHYDROCHLORIDE
- Product Name
- MINAPRINE DIHYDROCHLORIDE
- CAS No.
- 25905-77-5
- Chemical Name
- MINAPRINE DIHYDROCHLORIDE
- Synonyms
- minaprine;TS-370;Cantor;minaprin;Minaprina;Minaprinum;Minaprin diHCl;Minaprine 2HCl;MINAPRINE HYDROCHLORIDE;MINAPRIN DIHYDROCHLORIDE
- CBNumber
- CB4686336
- Molecular Formula
- C17H22N4O
- Formula Weight
- 298.38
- MOL File
- 25905-77-5.mol
MINAPRINE DIHYDROCHLORIDE Property
- Melting point:
- 122°
- Boiling point:
- 531.2±50.0 °C(Predicted)
- Density
- 1.156±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO : ≥ 35 mg/mL (117.30 mM)
- pka
- 6.80±0.10(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- M3157
- Product name
- Minaprine dihydrochloride
- Purity
- analytical standard
- Packaging
- 1g
- Price
- $61.4
- Updated
- 2022/05/15
- Product number
- M345203
- Product name
- Minaprine
- Packaging
- 2.5g
- Price
- $85
- Updated
- 2021/12/16
- Product number
- 456242
- Product name
- Minaprine
- Packaging
- 1g
- Price
- $305
- Updated
- 2021/12/16
- Product number
- API0009128
- Product name
- MINAPRINE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $654.16
- Updated
- 2021/12/16
- Product number
- CSN18166
- Product name
- Minaprine
- Packaging
- 25mg
- Price
- $35
- Updated
- 2021/12/16
MINAPRINE DIHYDROCHLORIDE Chemical Properties,Usage,Production
Originator
Cantor,Clin Midy,France,1979
Uses
Minaprine is a central nervous system (CNS) drug through the use of analog synthesis and CYP2D6 enzyme kinetic analyses.
Uses
muscle relaxant (skeletal)
Definition
ChEBI: Minaprine is a member of pyridazines, a secondary amine and a member of morpholines. It has a role as an antidepressant, a serotonin uptake inhibitor, a dopamine uptake inhibitor, a cholinergic drug and an antiparkinson drug.
Manufacturing Process
(a) Preparation of the free base: A mixture comprising 0.1 mol (20.4 g) of 3-chloro-4-methyl-6-phenylpyridazine and 0.2 mol (26.2 g) of N-(2-aminoethyl)-morpholine in 100 ml of n-butanol, with a pinch of copper powder, was heatedunder reflux for 12 hours. At the end of this time, the hot solution was pouredinto 200 ml of cold water. The resulting mixture was filtered through asintered glass filter and the precipitate washed with ether. The filtrate and theether washings were placed in a separating funnel and extracted with two 150ml portions of ether. The ethereal layer was then extracted with about 250 mlof N sulfuric acid.
The acid solution was made alkaline with a 10% aqueous solution of sodiumcarbonate, and left to crystallize overnight.
The solution was filtered, yielding the colorless needles which wererecrystallized from isopropanol. The yield was 15 g (53%).
(b) Preparation of the hydrochloride: The base was dissolved in the smallestamount possible of anhydrous acetone. Double that volume of anhydrousether was added, and a stream of hydrogen chloride gas was passed throughthe solution. The hydrochloride salt obtained was recrystallized from absolutealcohol. The yield after recrystallization was 17 g (90%).
brand name
Cantor (Sanofi).
Therapeutic Function
Antidepressant
MINAPRINE DIHYDROCHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
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