2-(4-METHOXY-BENZYL)-2H-PYRAZOL-3-YLAMINE

Uses Uses

Product Name: 2-(4-METHOXY-BENZYL)-2H-PYRAZOL-3-YLAMINE
CAS No.: 3528-45-8
Chemical Name: 2-(4-METHOXY-BENZYL)-2H-PYRAZOL-3-YLAMINE
Synonyms: TIMTEC-BB SBB011062;1-(4-Methoxybenzyl);5-Amino-1-(4-methoxybenzyl)pyrazole;[2-(4-methoxybenzyl)pyrazol-3-yl]amine;2-(4-Mehoxy-benzyl)-2H-pyrazol-3-ylamine;2-(4-METHOXY-BENZYL)-2H-PYRAZOL-3-YLAMINE;2-[(4-methoxyphenyl)methyl]-3-pyrazolamine;2-[(4-Methoxyphenyl)Methyl]pyrazol-3-aMine;1-[(4-Methoxyphenyl)methyl]-1H-pyrazol-5-amine;1H-pyrazol-5-amine, 1-[(4-methoxyphenyl)methyl]-
CBNumber: CB4693378
Molecular Formula: C11H13N3O
Formula Weight: 203.24
MOL File: Mol file

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2-(4-METHOXY-BENZYL)-2H-PYRAZOL-3-YLAMINE Property

Boiling point:: 407.4±30.0 °C(Predicted)
Density: 1.19±0.1 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
pka: 3.94±0.10(Predicted)
Appearance: Off-white to light yellow Solid

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Safety

Hazard Codes: Xi
HazardClass: IRRITANT
HS Code: 2933199090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: M265733
Product name: 1-(4-Methoxybenzyl)-1H-pyrazol-5-amine
Packaging: 500mg
Price: $200
Updated: 2021/12/16

Matrix Scientific

Product number: 019415
Product name: 2-(4-Methoxy-benzyl)-2H-pyrazol-3-ylamine
Packaging: 500mg
Price: $67
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0033069
Product name: 2-(4-METHOXY-BENZYL)-2H-PYRAZOL-3-YLAMINE
Purity: 95.00%
Packaging: 0.5G
Price: $682
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0033069
Product name: 2-(4-METHOXY-BENZYL)-2H-PYRAZOL-3-YLAMINE
Purity: 95.00%
Packaging: 1G
Price: $750.75
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0033069
Product name: 2-(4-METHOXY-BENZYL)-2H-PYRAZOL-3-YLAMINE
Purity: 95.00%
Packaging: 5G
Price: $1328.25
Updated: 2021/12/16

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2-(4-METHOXY-BENZYL)-2H-PYRAZOL-3-YLAMINE Chemical Properties,Usage,Production

Uses

1-(4-methoxybenzyl)-1H-pyrazol-5-amine (cas# 3528-45-8) is a useful research chemical.

Uses

2-(4-Methoxy-benzyl)-2H-pyrazol-3-ylamine is always used as synthesis intermediate for compounds which is used as medicament.

Synthesis

123-11-5

107-13-1

3528-45-8

Step 1. Synthesis of 1-(4-methoxybenzyl)-1H-pyrazol-5-amine. Hydrazine hydrate (NH2NH2-H2O, 23.19 mL, 478 mmol) was slowly added dropwise to a solution of tetrahydrofuran (THF, 250 mL) containing acrylonitrile (30 mL, 455 mmol) at 0 °C. After the dropwise addition, the reaction mixture was stirred at room temperature for 2 hours. Subsequently, 4-methoxybenzaldehyde (55.4 mL, 455 mmol) was added slowly dropwise. The reaction mixture was stirred overnight at room temperature and then continued to stir under reflux conditions for 2 hours. After completion of the reaction, it was cooled to room temperature and the reaction was quenched by the addition of 300 mL of ice water. The mixture was extracted with ethyl acetate (3 times) and the combined organic layers were extracted with 1N hydrochloric acid (HCl). The aqueous layer was neutralized with 10N aqueous sodium hydroxide (NaOH) and then extracted with ethyl acetate. The organic layer was washed sequentially with water and brine and dried over anhydrous sodium sulfate (Na2SO4). After filtration, it was recrystallized with ethyl ether (Et2O) to afford the target compound 1-(4-methoxybenzyl)-1H-pyrazol-5-amine as a white solid (50 g, 60% yield).

References

[1] Patent: WO2009/62308, 2009, A1. Location in patent: Page/Page column 51; 52
[2] Patent: WO2013/127266, 2013, A1. Location in patent: Page/Page column 132
[3] Patent: WO2013/127267, 2013, A1. Location in patent: Page/Page column 83
[4] Patent: WO2013/127269, 2013, A1. Location in patent: Page/Page column 145
[5] Bioorganic and Medicinal Chemistry Letters, 2013, vol. 23, # 20, p. 5488 - 5497

2-(4-METHOXY-BENZYL)-2H-PYRAZOL-3-YLAMINE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-(4-METHOXY-BENZYL)-2H-PYRAZOL-3-YLAMINE Suppliers

China 77 Germany 1 India 1 Russia 1 United Kingdom 1 United States 7 Global 88

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View Lastest Price from 2-(4-METHOXY-BENZYL)-2H-PYRAZOL-3-YLAMINE manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 2-(4-METHOXY-BENZYL)-2H-PYRAZOL-3-YLAMINE 3528-45-8
Price: US $0.10/KG
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 1000 tons
Release date: 2020-04-24

Shaanxi Dideu Medichem Co. Ltd

Product: 2-(4-Methoxy-benzyl)-2H-pyrazol-3-ylamine 3528-45-8
Price: US $0.00-0.00/Kg
Min. Order: 1KG
Purity: 99.0%+
Supply Ability: 100 tons
Release date: 2020-01-15

3528-45-8, 2-(4-METHOXY-BENZYL)-2H-PYRAZOL-3-YLAMINERelated Search:

(S)-(+)-Benzyl glycidyl ether p-Anisidine 4-Methoxybenzyl bromide

TIMTEC-BB SBB011062

2-(4-METHOXY-BENZYL)-2H-PYRAZOL-3-YLAMINE

1H-pyrazol-5-amine, 1-[(4-methoxyphenyl)methyl]-

2-[(4-Methoxyphenyl)Methyl]pyrazol-3-aMine

2-(4-Mehoxy-benzyl)-2H-pyrazol-3-ylamine

[2-(4-methoxybenzyl)pyrazol-3-yl]amine

1-[(4-Methoxyphenyl)methyl]-1H-pyrazol-5-amine

5-Amino-1-(4-methoxybenzyl)pyrazole

1-(4-Methoxybenzyl)

2-[(4-methoxyphenyl)methyl]-3-pyrazolamine

1-[(4-methoxyphenyl)methyl]-1H-pyridineazole-5-amine

3528-45-8