1-(4-CHLORO-BENZYL)-1 H-INDOLE-3-CARBALDEHYDE
- Product Name
- 1-(4-CHLORO-BENZYL)-1 H-INDOLE-3-CARBALDEHYDE
- CAS No.
- 75629-57-1
- Chemical Name
- 1-(4-CHLORO-BENZYL)-1 H-INDOLE-3-CARBALDEHYDE
- Synonyms
- CS-1229;Oncrasin 1;ZERO/008607;AKOS B014321;ZINC00439476;Oncrasin 1 >ASISCHEM N15726;ART-CHEM-BB B014321;CHEMBRDG-BB 5601604;1-(4-chlorobenzyl)indole-3-carbaldehyde
- CBNumber
- CB4698434
- Molecular Formula
- C16H12ClNO
- Formula Weight
- 269.73
- MOL File
- 75629-57-1.mol
1-(4-CHLORO-BENZYL)-1 H-INDOLE-3-CARBALDEHYDE Property
- Melting point:
- 115.0 to 119.0 °C
- Boiling point:
- 465.5±30.0 °C(Predicted)
- Density
- 1.21±0.1 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,2-8°C
- solubility
- DMSO: ≥20mg/mL
- form
- powder
- color
- off-white to light tan
- Sensitive
- Light Sensitive
Safety
- Hazard Codes
- Xi
- WGK Germany
- 3
- HS Code
- 2933.99.9000
- HazardClass
- IRRITANT
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- 496265
- Product name
- Oncrasin-1
- Packaging
- 25mg
- Price
- $128
- Updated
- 2023/06/20
- Product number
- O0516
- Product name
- Oncrasin-1
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $109
- Updated
- 2022/05/15
- Product number
- O0450
- Product name
- Oncrasin 1
- Purity
- >95.0%(HPLC)
- Packaging
- 10mg
- Price
- $112
- Updated
- 2024/03/01
- Product number
- O0450
- Product name
- Oncrasin 1
- Purity
- >95.0%(HPLC)
- Packaging
- 50mg
- Price
- $390
- Updated
- 2024/03/01
- Product number
- J64018
- Product name
- Oncrasin 1
- Packaging
- 10mg
- Price
- $128
- Updated
- 2021/12/16
1-(4-CHLORO-BENZYL)-1 H-INDOLE-3-CARBALDEHYDE Chemical Properties,Usage,Production
Uses
Oncrasin 1 is a proapoptotic compound.
Definition
ChEBI: Oncrasin-1 is a member of the class of indoles that is 1H-indole substituted by 4-chlorobenzyl and formyl groups at positions 1 and 3, respectively. It is an anti-cancer agent that is active against lung cancer cells with K-Ras mutations. It has a role as an apoptosis inducer and an antineoplastic agent. It is a member of indoles, a member of monochlorobenzenes and an arenecarbaldehyde.
Biological Activity
Proapoptotic agent that induces abnormal nuclear aggregation of PKC ι and suppresses RNA transcription. Exhibits antiproliferative effects against various human tumor cell lines with K-Ras mutations (IC 50 ≤ 3 μ M) with minimal effects on normal epithelial cells and inhibits human xenograft growth by 75% in vivo .
storage
+4°C
1-(4-CHLORO-BENZYL)-1 H-INDOLE-3-CARBALDEHYDE Preparation Products And Raw materials
Raw materials
Preparation Products
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