1-(4-CHLORO-BENZYL)-1 H-INDOLE-3-CARBALDEHYDE Property

Melting point:

115.0 to 119.0 °C

Boiling point:

465.5±30.0 °C(Predicted)

Density 

1.21±0.1 g/cm3(Predicted)

storage temp. 

Inert atmosphere,2-8°C

solubility 

DMSO: ≥20mg/mL

form 

powder

color 

off-white to light tan

Sensitive 

Light Sensitive

Safety

Hazard Codes 

Xi

WGK Germany 

3

HS Code 

2933.99.9000

HazardClass 

IRRITANT

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

1-(4-CHLORO-BENZYL)-1 H-INDOLE-3-CARBALDEHYDE Chemical Properties,Usage,Production

Uses

Oncrasin 1 is a proapoptotic compound.

Definition

ChEBI: Oncrasin-1 is a member of the class of indoles that is 1H-indole substituted by 4-chlorobenzyl and formyl groups at positions 1 and 3, respectively. It is an anti-cancer agent that is active against lung cancer cells with K-Ras mutations. It has a role as an apoptosis inducer and an antineoplastic agent. It is a member of indoles, a member of monochlorobenzenes and an arenecarbaldehyde.

Biological Activity

Proapoptotic agent that induces abnormal nuclear aggregation of PKC ι and suppresses RNA transcription. Exhibits antiproliferative effects against various human tumor cell lines with K-Ras mutations (IC 50 ≤ 3 μ M) with minimal effects on normal epithelial cells and inhibits human xenograft growth by 75% in vivo .

storage

+4°C