ChemicalBook > CAS DataBase List > 1-(4-CHLORO-BENZYL)-1 H-INDOLE-3-CARBALDEHYDE

1-(4-CHLORO-BENZYL)-1 H-INDOLE-3-CARBALDEHYDE

Product Name
1-(4-CHLORO-BENZYL)-1 H-INDOLE-3-CARBALDEHYDE
CAS No.
75629-57-1
Chemical Name
1-(4-CHLORO-BENZYL)-1 H-INDOLE-3-CARBALDEHYDE
Synonyms
CS-1229;Oncrasin 1;ZERO/008607;AKOS B014321;ZINC00439476;Oncrasin 1 >ASISCHEM N15726;ART-CHEM-BB B014321;CHEMBRDG-BB 5601604;Oncrasin-1, 10 mM in DMSO
CBNumber
CB4698434
Molecular Formula
C16H12ClNO
Formula Weight
269.73
MOL File
75629-57-1.mol
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1-(4-CHLORO-BENZYL)-1 H-INDOLE-3-CARBALDEHYDE Property

Melting point:
115.0 to 119.0 °C
Boiling point:
465.5±30.0 °C(Predicted)
Density 
1.21±0.1 g/cm3(Predicted)
storage temp. 
Inert atmosphere,2-8°C
solubility 
DMSO: ≥20mg/mL
form 
powder
color 
off-white to light tan
Sensitive 
Light Sensitive
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Safety

Hazard Codes 
Xi
WGK Germany 
3
HS Code 
2933.99.9000
HazardClass 
IRRITANT
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
496265
Product name
Oncrasin-1
Packaging
25mg
Price
$128
Updated
2023/06/20
Sigma-Aldrich
Product number
O0516
Product name
Oncrasin-1
Purity
≥98% (HPLC)
Packaging
5mg
Price
$109
Updated
2022/05/15
TCI Chemical
Product number
O0450
Product name
Oncrasin 1
Purity
>95.0%(HPLC)
Packaging
10mg
Price
$112
Updated
2024/03/01
TCI Chemical
Product number
O0450
Product name
Oncrasin 1
Purity
>95.0%(HPLC)
Packaging
50mg
Price
$390
Updated
2024/03/01
Alfa Aesar
Product number
J64018
Product name
Oncrasin 1
Packaging
10mg
Price
$128
Updated
2021/12/16
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1-(4-CHLORO-BENZYL)-1 H-INDOLE-3-CARBALDEHYDE Chemical Properties,Usage,Production

Uses

Oncrasin 1 is a proapoptotic compound.

Definition

ChEBI: Oncrasin-1 is a member of the class of indoles that is 1H-indole substituted by 4-chlorobenzyl and formyl groups at positions 1 and 3, respectively. It is an anti-cancer agent that is active against lung cancer cells with K-Ras mutations. It has a role as an apoptosis inducer and an antineoplastic agent. It is a member of indoles, a member of monochlorobenzenes and an arenecarbaldehyde.

Biological Activity

Proapoptotic agent that induces abnormal nuclear aggregation of PKC ι and suppresses RNA transcription. Exhibits antiproliferative effects against various human tumor cell lines with K-Ras mutations (IC 50 ≤ 3 μ M) with minimal effects on normal epithelial cells and inhibits human xenograft growth by 75% in vivo .

storage

+4°C

1-(4-CHLORO-BENZYL)-1 H-INDOLE-3-CARBALDEHYDE Preparation Products And Raw materials

Raw materials

Preparation Products

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1-(4-CHLORO-BENZYL)-1 H-INDOLE-3-CARBALDEHYDE Suppliers

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75629-57-1, 1-(4-CHLORO-BENZYL)-1 H-INDOLE-3-CARBALDEHYDERelated Search:

Indibulin 1-(3,4-DICHLORO-BENZYL)-1H-INDOLE-3-CARBALDEHYDE 1-(4-CHLORO-BENZYL)-1 H-INDOLE-3-CARBALDEHYDE ASISCHEM R41968 1-(2,4-DICHLORO-BENZYL)-1H-INDOLE-3-CARBALDEHYDE 1-(2-CHLORO-BENZYL)-1H-INDOLE-3-CARBALDEHYDE 1-(4-CHLOROBENZYL)-N-PHENYL-1H-INDOLE-3-CARBOXAMIDE METHYL 1-(2,4-DICHLOROBENZOYL)-1H-INDOLE-3-CARBOXYLATE METHYL 1-(4-CHLOROBENZOYL)-1H-INDOLE-3-CARBOXYLATE CBI-BB ZERO/008374 CBI-BB ZERO/005692 1-(4-CHLOROBENZYL)-N-(4-METHOXYPHENYL)-1H-INDOLE-3-CARBOXAMIDE 1H-INDOLE-3-CARBOXYLIC ACID, 1-[(2,4-DICHLOROPHENYL)METHYL]-,METHYL ESTER ASISCHEM V95851 1-(4-CHLOROBENZYL)-1H-INDOLE-3-CARBOXYLIC ACID 1H-INDOLE-3-CARBOXYLIC ACID, 1-[(3,4-DICHLOROPHENYL)METHYL]-, METHYL ESTER 5-BROMO-1-(4-CHLOROBENZYL)-1H-INDOLE-3-CARBALDEHYDE N-BENZYL-1-(4-CHLOROBENZYL)-1H-INDOLE-3-CARBOXAMIDE

  • 1-(4-CHLORO-BENZYL)-1 H-INDOLE-3-CARBALDEHYDE
  • AKOS B014321
  • CHEMBRDG-BB 5601604
  • ART-CHEM-BB B014321
  • ASISCHEM N15726
  • Oncrasin 1
  • 1-[(4-Chlorophenyl)methyl]-1H-indole-3-carboxaldehyde
  • 1-(4-chlorobenzyl)-1H-indole-3-carbaldehyde(SALTDATA: FREE)
  • 1-[(4-chlorophenyl)methyl]-1H-indole-3-carbaldehyde
  • CS-1229
  • Oncrasin-1 - CAS 75629-57-1 - Calbiochem
  • 1-[(4-chlorophenyl)methyl]-3-indolecarboxaldehyde
  • ZERO/008607
  • ZINC00439476
  • 1-[(4-chlorophenyl)methyl]indole-3-carbaldehyde
  • 1-(4-chlorobenzyl)indole-3-carbaldehyde
  • Oncrasin 1 &gt
  • 1H-Indole-3-carboxaldehyde, 1-[(4-chlorophenyl)methyl]-
  • 1-(4-Chlorobenzyl)-1H-indole-3-carboxaldehyde
  • Oncrasin-1, 10 mM in DMSO
  • 75629-57-1
  • C16H12CINO
  • Apoptosis Inducers