3-IODO-1-METHYL-1H-PYRAZOLE
- Product Name
- 3-IODO-1-METHYL-1H-PYRAZOLE
- CAS No.
- 92525-10-5
- Chemical Name
- 3-IODO-1-METHYL-1H-PYRAZOLE
- Synonyms
- 1-Methyl-3-iodopyrazole;3-Iodo-1-methylpyrazole;3-idio-1-methylpyrazole;3-Iodo-1-methy-1h-pyrazole;3-IODO-1-METHYL-1H-PYRAZOLE;3-Iodo-1-methyl-1H-pyrazole97%;3-Iodo-1-methyl-1H-pyrazole 97%;3-Iodo-1-methyl-pyrazole 97%min;1H-?Pyrazole, 3-?iodo-?1-?methyl-
- CBNumber
- CB4702085
- Molecular Formula
- C4H5IN2
- Formula Weight
- 208
- MOL File
- 92525-10-5.mol
3-IODO-1-METHYL-1H-PYRAZOLE Property
- Boiling point:
- 226.9℃
- Density
- 2.07
- Flash point:
- 91.1℃
- refractive index
- 1.5880
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- form
- Liquid
- pka
- -0.03±0.10(Predicted)
- color
- Brown
- Sensitive
- Light Sensitive
- InChI
- InChI=1S/C4H5IN2/c1-7-3-2-4(5)6-7/h2-3H,1H3
- InChIKey
- SITJXRWLFQGWCB-UHFFFAOYSA-N
- SMILES
- N1(C)C=CC(I)=N1
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/38-41-37/38
- Safety Statements
- 23-26-36/37/39-39
- WGK Germany
- nwg
- Hazard Note
- Harmful
- HS Code
- 2933199090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H315Causes skin irritation
H318Causes serious eye damage
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
N-Bromosuccinimide Price
- Product number
- 729396
- Product name
- 3-Iodo-1-methyl-1H-pyrazole
- Purity
- 95%
- Packaging
- 500mg
- Price
- $156
- Updated
- 2023/06/20
- Product number
- I709045
- Product name
- 3-Iodo-1-methyl-1H-pyrazole
- Packaging
- 500mg
- Price
- $155
- Updated
- 2021/12/16
- Product number
- 280345
- Product name
- 3-Iodo-1-methyl-1H-pyrazole
- Packaging
- 5g
- Price
- $1663
- Updated
- 2021/12/16
- Product number
- HCH0021963
- Product name
- 3-IODO-1-METHYL-1H-PYRAZOLE
- Purity
- 95.00%
- Packaging
- 5G
- Price
- $2477.48
- Updated
- 2021/12/16
- Product number
- HCH0021963
- Product name
- 3-IODO-1-METHYL-1H-PYRAZOLE
- Purity
- 95.00%
- Packaging
- 10G
- Price
- $3632.48
- Updated
- 2021/12/16
3-IODO-1-METHYL-1H-PYRAZOLE Chemical Properties,Usage,Production
Application
3-Iodo-1-methyl-1H-pyrazole is a useful research chemical.
Synthesis
1904-31-0
92525-10-5
The general procedure for the synthesis of 3-iodo-1-methylpyrazole from N-methyl-3-aminopyrazole was as follows: N-methyl-3-aminopyrazole (2000 g, 20.6 mol, 1.0 eq.) was dissolved in a mixture of 6,000 mL of concentrated hydrochloric acid and 2,000 mL of water, which was cooled down to 0-5 °C in an ice-salt bath. Subsequently, 3.5 L of saturated aqueous sodium nitrite (NaNO2, 2842.8 g, 41.2 mol, 2.0 eq.) was slowly added dropwise, with mechanical stirring maintained during the dropwise addition. After 20 minutes of reaction, the reaction solution was slowly added dropwise to 8000 mL of aqueous potassium iodide solution (8549.0 g, 51.5 mol, 2.5 equiv.) that was pre-cooled to 0 °C. After the dropwise addition, the reaction mixture was allowed to warm naturally to room temperature and the reaction was continued for 4 hours. The progress of the reaction was monitored by thin layer chromatography (TLC) and after confirming the completion of the reaction, it was extracted twice with ethyl acetate. The organic phases were combined, washed with saturated brine and dried, followed by concentration of the organic phase. The crude product was purified by fast column chromatography to afford the target compound 3-iodo-1-methyl-1H-pyrazole (3473.8 g, 16.7 mol) in 81.0% yield.
References
[1] Patent: CN105669733, 2016, A. Location in patent: Paragraph 0031; 0032; 0033; 0034
[2] Patent: WO2015/175579, 2015, A1. Location in patent: Paragraph 351
3-IODO-1-METHYL-1H-PYRAZOLE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-IODO-1-METHYL-1H-PYRAZOLE manufacturers
- Product
- 3-IODO-1-METHYL-1H-PYRAZOLE 92525-10-5
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2020-01-02