1-Boc-3-iodoindazole
- Product Name
- 1-Boc-3-iodoindazole
- CAS No.
- 290368-00-2
- Chemical Name
- 1-Boc-3-iodoindazole
- Synonyms
- 1-Boc-3-iodoindazole;1-Boc-3-iodo-1H-indazole;N-(tert-Butoxycarbonyl)-3-iodoindazole;tert-butyl 3-iodo-1H-indazole-1-carboxylate;3-Iodo-indazole-1-carboxylic acid tert-butyl ester;1H-Indazole-1-carboxylic acid, 3-iodo-, 1,1-diMethylethyl ester
- CBNumber
- CB91216061
- Molecular Formula
- C12H13IN2O2
- Formula Weight
- 344.15
- MOL File
- 290368-00-2.mol
1-Boc-3-iodoindazole Property
- Melting point:
- 117℃
- Density
- 1.65
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- Appearance
- White to off-white Solid
Safety
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H312Harmful in contact with skin
H332Harmful if inhaled
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P322Specific measures (see …on this label).
P330Rinse mouth.
P363Wash contaminated clothing before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- B695205
- Product name
- tert-Butyl3-Iodo-1H-indazole-1-carboxylate
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- FB140400
- Product name
- 1-Boc-3-iodo-1H-indazole
- Packaging
- 1g
- Price
- $83
- Updated
- 2021/12/16
- Product number
- W5165
- Product name
- 1-Boc-3-iodo-1H-indazole
- Packaging
- 1g
- Price
- $137
- Updated
- 2021/12/16
- Product number
- FB140400
- Product name
- 1-Boc-3-iodo-1H-indazole
- Packaging
- 2g
- Price
- $145
- Updated
- 2021/12/16
- Product number
- FB140400
- Product name
- 1-Boc-3-iodo-1H-indazole
- Packaging
- 5G
- Price
- $290
- Updated
- 2021/12/16
1-Boc-3-iodoindazole Chemical Properties,Usage,Production
Synthesis
24424-99-5
66607-27-0
290368-00-2
1. 3-Iodo-1H-indazole (0.2 g, 0.82 mmol), di-tert-butyl dicarbonate (0.2 g, 0.92 mmol) and triethylamine (1 mL) were mixed and placed under ultrasonic radiation for 10 minutes. 2. After completion of the reaction, the reaction mixture was neutralized with 1 M HCl solution. 3. The neutralized solution was extracted using dichloromethane (3 x 30 mL). 4. The organic layers were combined and dried over anhydrous sodium sulfate. 5. Vacuum remove the solvent to give the pure product 3-iodo-1H-indazole-1-carboxylic acid tert-butyl ester as light yellow crystals. Yield: 100%; Melting point: 93-95°C; IR (KBr) ν (cm^-1): 1728 (C=O); 1150 (C-O); 424 (C-I). 1H-NMR (CDCl3) δ (ppm): 8.09 (1H, d, J=8.5 Hz, H-7); 7.55 (1H, t, J=7.8 Hz, H-4); 7.46 (1H, d, J=7.9 Hz, H-6); 7.33 (1H, t, J=7.6 Hz, H-5); 1.71 (9H, s, CH3). 13C-NMR (CDCl3) δ (ppm): 148.35; 139.59; 130.17; 129.98; 124.21; 121.96; 114.56; 102.95; 85.48; 28.18. HRMS (ESI) m/z calculated value C12H13IN2O2 [M+H]+: 344.0022, measured value: 344.0016. For the synthesis of tert-butyl 3-iodo-5-nitro-1H-indazole-1-carboxylate (2b): 1. 3-iodo-5-nitro-1H-indazole (0.2 g, 0.69 mmol), di-tert-butyl dicarbonate (0.17 g, 0.78 mmol) and triethylamine (1 mL) were used as raw materials, and the same procedure as above was followed. 2. 0.27 g of pure product as a pale yellow solid was obtained. Yield: 100%; Melting point: 144-145 °C; IR (KBr) ν (cm^-1): 1744 (C=O); 1528 (NO2).
References
[1] Molecules, 2018, vol. 23, # 8,
[2] Patent: WO2015/58140, 2015, A1. Location in patent: Paragraph 00447
[3] Patent: WO2016/58544, 2016, A1. Location in patent: Paragraph 389; 390
[4] Beilstein Journal of Organic Chemistry, 2013, vol. 9, p. 1501 - 1507
[5] Patent: WO2014/47662, 2014, A2. Location in patent: Paragraph 00283
1-Boc-3-iodoindazole Preparation Products And Raw materials
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View Lastest Price from 1-Boc-3-iodoindazole manufacturers
- Product
- 1-Boc-3-iodoindazole 290368-00-2
- Price
- US $6.60/KG
- Min. Order
- 1KG
- Purity
- 97%-99%
- Supply Ability
- 1kg-1000kg
- Release date
- 2019-12-25