ACDCRGDCFCG (DISULFIDE BRIDGE: 2-10 AND 4-8)

Product Name: ACDCRGDCFCG (DISULFIDE BRIDGE: 2-10 AND 4-8)
CAS No.: 332179-76-7
Chemical Name: ACDCRGDCFCG (DISULFIDE BRIDGE: 2-10 AND 4-8)
Synonyms: RGD-4C;ACDCRGDCFCG (DISULFIDE BRIDGE: 2-10 AND 4-8);H-Ala-Cys-Asp-Cys-Arg-Gly-Asp-Cys-Phe-Cys-Gly-OH(Cys2-Cys10 , Cys4-Cys8);H-ALA-CYS-ASP-CYS-ARG-GLY-ASP-CYS-PHE-CYS-GLY-OH (DISULFIDE BRIDGE: 2-10 AND 4-8);ALA-CYS-ASP-CYS-ARG-GLY-ASP-CYS-PHE-CYS-GLY(DISULFIDE BRIDGE:CYS2-CYS10, CYS4-CYS8);Glycine, L-alanyl-L-cysteinyl-L-α-aspartyl-L-cysteinyl-L-arginylglycyl-L-α-aspartyl-L-cysteinyl-L-phenylalanyl-L-cysteinyl-, cyclic (2→10),(4→8)-bis(disulfide)
CBNumber: CB4702333
Molecular Formula: C42H60N14O16S4
Formula Weight: 1145.27
MOL File: Mol file

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ACDCRGDCFCG (DISULFIDE BRIDGE: 2-10 AND 4-8) Property

Density: 1.69±0.1 g/cm3(Predicted)
pka: 3.57±0.10(Predicted)
form: Solid
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: PEP0003043
Product name: RGD - 4C
Purity: 95.00%
Packaging: 1MG
Price: $702.19
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: PEP0003043
Product name: RGD - 4C
Purity: 95.00%
Packaging: 2MG
Price: $772.23
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: PEP0003043
Product name: RGD - 4C
Purity: 95.00%
Packaging: 5MG
Price: $1063.54
Updated: 2021/12/16

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ACDCRGDCFCG (DISULFIDE BRIDGE: 2-10 AND 4-8) Chemical Properties,Usage,Production

Uses

RGD-4C is a arginine-glycine-aspartic acid peptide (ACDCRGDCFC) with integrin binding activity. The Arg-Gly-Asp (RGD) sequence serves as the primary integrin recognition site in extracellular matrix proteins, and peptides containing this sequence can mimic the recognition specificity of the matrix proteins. RGD-4C is a αv-integrin ligand, can conjugate with bioactive molecule to exert antitumor effects in animal models[1][2][3].

in vivo

RGD-4C (9.11 mg/kg; injection; single dose) inhibits the growth of B16F10 mouse melanoma in vivo^[2].
Modified RGD-4C fused with the N-terminus of plant-derived single-chain ribosome inactivating protein saporin (SAP) (called RGD-SAP), (diluted in sodium chloride, 0.9%; i.v.; 200 μL; every 5 days, for 3 times) exerts anti-tumor activity in a model of muscle invasive bladder cancer^[3].
RGD-SAP in combination with mitomycin C, a chemotherapeutic drug, increases the survival of mice bearing orthotopic bladder cancer with no evidence of systemic toxicity^[3].

References

[1] Assa-Munt N, et al. Solution structures and integrin binding activities of an RGD peptide with two isomers. Biochemistry. 2001 Feb 27;40(8):2373-8. DOI:10.1021/bi002101f
[2] Yin R, et al. Effect of RGD-4C position is more important than disulfide bonds on antiangiogenic activity of RGD-4C modified endostatin derived synthetic polypeptide. Bioconjug Chem. 2010 Jul 21;21(7):1142-7. DOI:10.1021/bc900292y
[3] Zuppone S, et al. A Novel RGD-4C-Saporin Conjugate Inhibits Tumor Growth in Mouse Models of Bladder Cancer. Front Oncol. 2022 Apr 11;12:846958. DOI:10.3389/fonc.2022.846958

ACDCRGDCFCG (DISULFIDE BRIDGE: 2-10 AND 4-8) Preparation Products And Raw materials

Raw materials

Preparation Products

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ACDCRGDCFCG (DISULFIDE BRIDGE: 2-10 AND 4-8) Suppliers

China 69 Germany 1 United States 4 Global 74

GL Biochem (Shanghai) Ltd

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Nanjing Meihao Pharmaceutical Technology Co., Ltd.

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Hangzhou Go Top Peptide Biotech

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332179-76-7, ACDCRGDCFCG (DISULFIDE BRIDGE: 2-10 AND 4-8)Related Search:

RGDV GRGDNP H-ARG-GLY-GLU-SER-OH ARG-GLY-ASP-SER ARG-GLY-ASP-THR ARG-GLY-ASP-SER-PRO-ALA-SER-SER-LYS-PRO H-ARG-GLY-ASP-CYS-OH ARG-GLY-ASP

ACDCRGDCFCG (DISULFIDE BRIDGE: 2-10 AND 4-8)

H-ALA-CYS-ASP-CYS-ARG-GLY-ASP-CYS-PHE-CYS-GLY-OH (DISULFIDE BRIDGE: 2-10 AND 4-8)

ALA-CYS-ASP-CYS-ARG-GLY-ASP-CYS-PHE-CYS-GLY(DISULFIDE BRIDGE:CYS2-CYS10, CYS4-CYS8)

RGD-4C

H-Ala-Cys-Asp-Cys-Arg-Gly-Asp-Cys-Phe-Cys-Gly-OH(Cys2-Cys10 , Cys4-Cys8)

Glycine, L-alanyl-L-cysteinyl-L-α-aspartyl-L-cysteinyl-L-arginylglycyl-L-α-aspartyl-L-cysteinyl-L-phenylalanyl-L-cysteinyl-, cyclic (2→10),(4→8)-bis(disulfide)

332179-76-7

C42H60N14O16S4

Peptide