4-CHLORO-2-METHYL-THIENO[2,3-D]PYRIMIDINE
Uses- Product Name
- 4-CHLORO-2-METHYL-THIENO[2,3-D]PYRIMIDINE
- CAS No.
- 56843-79-9
- Chemical Name
- 4-CHLORO-2-METHYL-THIENO[2,3-D]PYRIMIDINE
- Synonyms
- Propanoicacid,2-(9-nitrophenoxy)-;4-CHLORO-2-METHYL-THIENO[2,3-D]PYRIMIDIN;4-CHLORO-2-METHYL-THIENO[2,3-D]PYRIMIDINE;Thieno[2,3-d]pyrimidine, 4-chloro-2-methyl-;3-Pyridinecarboxylicacid,2,9-dimethyl-,methylester;4-CHLORO-2-METHYL-THIENO[2,3-D]PYRIMIDINE ISO 9001：2015 REACH
- CBNumber
- CB4702924
- Molecular Formula
- C7H5ClN2S
- Formula Weight
- 184.65
- MOL File
- 56843-79-9.mol
4-CHLORO-2-METHYL-THIENO[2,3-D]PYRIMIDINE Property
- Melting point:
- 90 - 92°C
- Boiling point:
- 208.1±22.0 °C(Predicted)
- Density
- 1.445±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 0.87±0.40(Predicted)
- color
- Beige
- InChI
- InChI=1S/C7H5ClN2S/c1-4-9-6(8)5-2-3-11-7(5)10-4/h2-3H,1H3
- InChIKey
- VYUDXHRVZLZWMP-UHFFFAOYSA-N
- SMILES
- C1(C)=NC(Cl)=C2C=CSC2=N1
Safety
- HS Code
- 2934999090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- C368935
- Product name
- 4-Chloro-2-methylthieno[2,3-d]pyrimidine
- Packaging
- 50mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- FC148754
- Product name
- 4-Chloro-2-methyl-thieno[2,3-d]pyrimidine
- Packaging
- 50mg
- Price
- $94
- Updated
- 2021/12/16
- Product number
- FC148754
- Product name
- 4-Chloro-2-methyl-thieno[2,3-d]pyrimidine
- Packaging
- 100mg
- Price
- $164
- Updated
- 2021/12/16
- Product number
- OR932569
- Product name
- 4-Chloro-2-methylthieno[2,3-d]pyrimidine
- Purity
- 95%
- Packaging
- 250mg
- Price
- $250
- Updated
- 2021/12/16
- Product number
- X0261
- Product name
- 4-Chloro-2-methylthieno[2,3-d]pyrimidine
- Packaging
- 1g
- Price
- $314
- Updated
- 2021/12/16
4-CHLORO-2-METHYL-THIENO[2,3-D]PYRIMIDINE Chemical Properties,Usage,Production
Uses
4-Chloro-2-methylthieno[2,3-D]pyrimidine can be used as a pharmaceutical synthesis intermediate. It can be prepared from methyl 2-aminothiophene-3-carboxylic acid as a reactant, and then further reacted with phosphorus oxychloride to obtain the intermediate 2-methyl-3H-thieno[2,3-d]pyrimidine-4-one.
Synthesis
21582-51-4
56843-79-9
The general procedure for the synthesis of 4-chloro-2-methylthieno[2,3-D]pyrimidines from 4-hydroxy-2-methylthieno[2,3-D]pyrimidines was as follows: a few drops of pyridine were added to a solution of 2-methylthieno[2,3-d]pyrimidin-4(3H)-one (300 mg, 1.80 mmol) in phosphorus oxychloride (POCl3, 5.0 mL). The reaction mixture was heated to reflux for 24 hours. Upon completion of the reaction, the mixture was cooled to room temperature and slowly poured into ice water. Subsequently, saturated sodium carbonate (Na2CO3) solution was added to neutralize the excess trichlorophosphate. The aqueous phase was extracted with ethyl acetate (EtOAc) and the organic phase was combined. The organic phase was washed with saturated saline, dried over anhydrous sodium sulfate (Na2SO4) and concentrated under reduced pressure to remove the solvent. The crude product was purified by silica gel column chromatography with the eluent of petroleum ether/ethyl acetate (8:2, v/v) to afford the target compound 4-chloro-2-methylthieno[2,3-D]pyrimidine in 61% yield. The product was a yellow solid with a melting point of 93 °C. Nuclear magnetic resonance hydrogen spectrum (1H NMR, 200 MHz, CDCl3) δ= 7.48 (d, J = 6.0 Hz, 1H), 7.35 (d, J = 6.0 Hz, 1H), 2.79 (s, 3H). Nuclear magnetic resonance carbon spectrum (13C NMR, 50 MHz, CDCl3) δ= 169.2, 163.0, 154.4, 126.8, 126.6, 119.5, 25.5. liquid chromatography-mass spectrometry (LC-MS, ESI, 35 eV): retention time (tR) = 1.84 min, mass-to-charge ratio (m/z) = 185 [M + H]+ The results are summarized in the following table.
References
[1] European Journal of Medicinal Chemistry, 2017, vol. 125, p. 68 - 86
4-CHLORO-2-METHYL-THIENO[2,3-D]PYRIMIDINE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-CHLORO-2-METHYL-THIENO[2,3-D]PYRIMIDINE manufacturers
- Product
- 4-CHLORO-2-METHYL-THIENO[2,3-D]PYRIMIDINE 56843-79-9
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.0% min
- Supply Ability
- 100 tons min
- Release date
- 2021-05-13