ChemicalBook > CAS DataBase List > 4-CHLORO-2-METHYL-5,6,7,8-TETRAHYDRO[1]BENZOTHIENO[2,3-D]PYRIMIDINE

4-CHLORO-2-METHYL-5,6,7,8-TETRAHYDRO[1]BENZOTHIENO[2,3-D]PYRIMIDINE

Product Name
4-CHLORO-2-METHYL-5,6,7,8-TETRAHYDRO[1]BENZOTHIENO[2,3-D]PYRIMIDINE
CAS No.
81765-97-1
Chemical Name
4-CHLORO-2-METHYL-5,6,7,8-TETRAHYDRO[1]BENZOTHIENO[2,3-D]PYRIMIDINE
Synonyms
AKOS 92583;IFLAB-BB F0307-0219;4-CHLORO-2-METHYL-5,6,7,8-TETRAHYDRO[1]BENZOTHIENO[2,3-D]PYRIMIDINE;4-CHLORO-2-METHYL-5,6,7,8-TETRAHYDROBENZO[4,5]THIENO[2,3-D]PYRIMIDINE;[1]BENZOTHIENO[2,3-D]PYRIMIDINE, 4-CHLORO-5,6,7,8-TETRAHYDRO-2-METHYL-;4-Chloro-2-Methyl-5,6,7,8-tetrahydrobenzo[b]thieno[2,3-d]pyriMidine, 96%
CBNumber
CB7781856
Molecular Formula
C11H11ClN2S
Formula Weight
238.74
MOL File
81765-97-1.mol
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4-CHLORO-2-METHYL-5,6,7,8-TETRAHYDRO[1]BENZOTHIENO[2,3-D]PYRIMIDINE Property

Melting point:
94 °C
Density 
1.367±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
pka
1.27±0.20(Predicted)
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Safety

HS Code 
2934999090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TRC
Product number
C368828
Product name
4-Chloro-2-methyl-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidine
Packaging
25mg
Price
$45
Updated
2021/12/16
Matrix Scientific
Product number
135564
Product name
4-Chloro-2-methyl-5,6,7,8-tetrahydro-benzo[4,5]thieno[2,3-d]pyrimidine
Purity
95%+
Packaging
1g
Price
$101
Updated
2021/12/16
SynQuest Laboratories
Product number
7H66-5-88
Product name
4-Chloro-2-methyl-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidine
Packaging
250mg
Price
$157
Updated
2021/12/16
Matrix Scientific
Product number
135564
Product name
4-Chloro-2-methyl-5,6,7,8-tetrahydro-benzo[4,5]thieno[2,3-d]pyrimidine
Purity
95%+
Packaging
2.500g
Price
$215
Updated
2021/12/16
Matrix Scientific
Product number
135564
Product name
4-Chloro-2-methyl-5,6,7,8-tetrahydro-benzo[4,5]thieno[2,3-d]pyrimidine
Purity
95%+
Packaging
5g
Price
$323
Updated
2021/12/16
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4-CHLORO-2-METHYL-5,6,7,8-TETRAHYDRO[1]BENZOTHIENO[2,3-D]PYRIMIDINE Chemical Properties,Usage,Production

Uses

4-chloro-2-methyl-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidine is a useful reactant for the synthesis of thieno[2,?3-?d]?pyrimidines and furo[2,?3-?d]?pyrimidines derivatives, for the use as c-?Met inhibitiors as a potential antitumor agents.

Synthesis

19819-15-9

81765-97-1

GENERAL METHOD: Different thieno[2,3-d]pyrimidin-4-one derivatives (6a-d or f-i) (1 eq.) were mixed with phosphorochloridic acid chloride (2.9 mL/mmol eq.) and heated to reflux for 8 hours. Upon completion of the reaction, the reaction mixture was cooled in an ice bath and neutralized by slow addition of saturated aqueous sodium bicarbonate solution. Subsequently, the reaction mixture was extracted with ethyl acetate (15 mL/millimolar equivalent), the organic layer was separated, dried with anhydrous magnesium sulfate and concentrated under reduced pressure. The crude product was purified by fast column chromatography with the eluent being n-hexane-ethyl acetate (initial ratio 100:0 v/v), which was gradually adjusted to n-hexane-ethyl acetate (85:15 v/v), unless otherwise stated.

References

[1] Chemical and Pharmaceutical Bulletin, 1982, vol. 30, # 1, p. 326 - 332
[2] European Journal of Medicinal Chemistry, 2016, vol. 123, p. 31 - 47
[3] Synthesis, 2001, # 14, p. 2119 - 2123

4-CHLORO-2-METHYL-5,6,7,8-TETRAHYDRO[1]BENZOTHIENO[2,3-D]PYRIMIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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4-CHLORO-2-METHYL-5,6,7,8-TETRAHYDRO[1]BENZOTHIENO[2,3-D]PYRIMIDINE Suppliers

Belgium 1 Canada 1 China 13 Germany 2 India 1 Ukraine 2 United Kingdom 2 United States 7 Global 29
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30123
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84
Aikon International Limited
Tel
025-66113011 13155353615
Fax
(7)02557626880
Email
qzhang@aikonchem.com
Country
China
ProdList
15394
Advantage
58
Henan Weituxi Chemical Technology Co., Ltd.
Tel
0371-63284658 18135795563
Fax
QQ:2885349392
Email
2885349392@qq.com
Country
China
ProdList
9992
Advantage
58
Energy Chemical
Tel
021-58432009 400-005-6266
Fax
021-58436166
Email
marketing@energy-chemical.com
Country
China
ProdList
44918
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Hubei Co-prosperity Medicine Technonlogy Co., Ltd
Tel
2383948258 19172820304
Email
2383948258@qq.com
Country
China
ProdList
12987
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58
Beijing Jin Ming Biotechnology Co., Ltd.
Tel
010-60605840 15801484223;
Email
psaitong@jm-bio.com
Country
China
ProdList
29757
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58
Bide Pharmatech Ltd.
Tel
400-6005915
Email
sales@picasso-e.com
Country
China
ProdList
39653
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58
Beijing Solarbio Science & Tecnology Co., Ltd.
Tel
010-50973130 17801761073
Email
Gsiyu@solarbio.com
Country
China
ProdList
50464
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58
Suzhou Haiben Pharmaceutical Co., Ltd
Tel
19353112242
Email
1816280386@qq.com
Country
China
ProdList
8045
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58
Changzhou Qianai Biotechnology Co., Ltd
Tel
051915240519135 13961152745
Email
yudiguimo@126.COM
Country
China
ProdList
10000
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58

81765-97-1, 4-CHLORO-2-METHYL-5,6,7,8-TETRAHYDRO[1]BENZOTHIENO[2,3-D]PYRIMIDINERelated Search:

4-CHLORO-2-METHYL-5,6,7,8-TETRAHYDRO[1]BENZOTHIENO[2,3-D]PYRIMIDINE 4-CHLORO-7-METHYL-5,6,7,8-TETRAHYDRO[1]BENZOTHIENO[2,3-D]PYRIMIDINE Pyrimidine 4-CHLORO-2-PYRIDIN-3-YL-5,6,7,8-TETRAHYDRO[1]BENZOTHIENO[2,3-D]PYRIMIDINE 4-CHLORO-7-METHYL-2-PYRIDIN-3-YL-5,6,7,8-TETRAHYDRO[1]BENZOTHIENO[2,3-D]PYRIMIDINE 4-CHLORO-2,7-DIMETHYL-5,6,7,8-TETRAHYDRO[1]BENZOTHIENO[2,3-D]PYRIMIDINE 4-CHLORO-7-METHYL-2-[(PHENYLTHIO)METHYL]-5,6,7,8-TETRAHYDRO[1]BENZOTHIENO[2,3-D]PYRIMIDINE 4-CHLORO-2-(MORPHOLIN-4-YLMETHYL)-5,6,7,8-TETRAHYDRO[1]BENZOTHIENO[2,3-D]PYRIMIDINE 4-CHLORO-2-([(4-CHLOROPHENYL)THIO]METHYL)-7-METHYL-5,6,7,8-TETRAHYDRO[1]BENZOTHIENO[2,3-D]PYRIMIDINE 2-([(4-BROMOPHENYL)THIO]METHYL)-4-CHLORO-7-METHYL-5,6,7,8-TETRAHYDRO[1]BENZOTHIENO[2,3-D]PYRIMIDINE 4-CHLORO-2-CHLOROMETHYL-5,6,7,8-TETRAHYDRO-BENZO[4,5]THIENO[2,3-D]PYRIMIDINE 4-CHLORO-2-(PIPERIDIN-1-YLMETHYL)-5,6,7,8-TETRAHYDRO[1]BENZOTHIENO[2,3-D]PYRIMIDINE 4-CHLORO-2-[[(4-CHLOROPHENYL)THIO]METHYL]-5,6,7,8-TETRAHYDRO[1]BENZOTHIENO[2,3-D]PYRIMIDINE 4-CHLORO-2-ETHYL-5,6,7,8-TETRAHYDRO[1]BENZOTHIENO[2,3-D]PYRIMIDINE 4-CHLORO-2-[(PHENYLTHIO)METHYL]-5,6,7,8-TETRAHYDRO[1]BENZOTHIENO[2,3-D]PYRIMIDINE AKOS 92590 2-[(E)-2-(4-BROMOPHENYL)VINYL]-4-CHLORO-5,6,7,8-TETRAHYDRO[1]BENZOTHIENO[2,3-D]PYRIMIDINE 2-(4-BROMO-PHENYLSULFANYLMETHYL)-4-CHLORO-5,6,7,8-TETRAHYDRO-BENZO[4,5]THIENO[2,3-D]PYRIMIDINE

  • IFLAB-BB F0307-0219
  • [1]BENZOTHIENO[2,3-D]PYRIMIDINE, 4-CHLORO-5,6,7,8-TETRAHYDRO-2-METHYL-
  • 4-CHLORO-2-METHYL-5,6,7,8-TETRAHYDRO[1]BENZOTHIENO[2,3-D]PYRIMIDINE
  • 4-CHLORO-2-METHYL-5,6,7,8-TETRAHYDROBENZO[4,5]THIENO[2,3-D]PYRIMIDINE
  • AKOS 92583
  • 4-Chloro-2-Methyl-5,6,7,8-tetrahydrobenzo[b]thieno[2,3-d]pyriMidine, 96%
  • 81765-97-1
  • C11H11ClN2S