ChemicalBook > CAS DataBase List > 4-CHLORO-2-METHYL-5,6,7,8-TETRAHYDRO[1]BENZOTHIENO[2,3-D]PYRIMIDINE

4-CHLORO-2-METHYL-5,6,7,8-TETRAHYDRO[1]BENZOTHIENO[2,3-D]PYRIMIDINE

Product Name
4-CHLORO-2-METHYL-5,6,7,8-TETRAHYDRO[1]BENZOTHIENO[2,3-D]PYRIMIDINE
CAS No.
81765-97-1
Chemical Name
4-CHLORO-2-METHYL-5,6,7,8-TETRAHYDRO[1]BENZOTHIENO[2,3-D]PYRIMIDINE
Synonyms
AKOS 92583;IFLAB-BB F0307-0219;4-CHLORO-2-METHYL-5,6,7,8-TETRAHYDRO[1]BENZOTHIENO[2,3-D]PYRIMIDINE;4-CHLORO-2-METHYL-5,6,7,8-TETRAHYDROBENZO[4,5]THIENO[2,3-D]PYRIMIDINE;[1]BENZOTHIENO[2,3-D]PYRIMIDINE, 4-CHLORO-5,6,7,8-TETRAHYDRO-2-METHYL-;4-Chloro-2-Methyl-5,6,7,8-tetrahydrobenzo[b]thieno[2,3-d]pyriMidine, 96%
CBNumber
CB7781856
Molecular Formula
C11H11ClN2S
Formula Weight
238.74
MOL File
81765-97-1.mol
More
Less

4-CHLORO-2-METHYL-5,6,7,8-TETRAHYDRO[1]BENZOTHIENO[2,3-D]PYRIMIDINE Property

Melting point:
94 °C
Density 
1.367±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
pka
1.27±0.20(Predicted)
More
Less

Safety

HS Code 
2934999090
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

More
Less

N-Bromosuccinimide Price

TRC
Product number
C368828
Product name
4-Chloro-2-methyl-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidine
Packaging
25mg
Price
$45
Updated
2021/12/16
Matrix Scientific
Product number
135564
Product name
4-Chloro-2-methyl-5,6,7,8-tetrahydro-benzo[4,5]thieno[2,3-d]pyrimidine
Purity
95%+
Packaging
1g
Price
$101
Updated
2021/12/16
SynQuest Laboratories
Product number
7H66-5-88
Product name
4-Chloro-2-methyl-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidine
Packaging
250mg
Price
$157
Updated
2021/12/16
Matrix Scientific
Product number
135564
Product name
4-Chloro-2-methyl-5,6,7,8-tetrahydro-benzo[4,5]thieno[2,3-d]pyrimidine
Purity
95%+
Packaging
2.500g
Price
$215
Updated
2021/12/16
Matrix Scientific
Product number
135564
Product name
4-Chloro-2-methyl-5,6,7,8-tetrahydro-benzo[4,5]thieno[2,3-d]pyrimidine
Purity
95%+
Packaging
5g
Price
$323
Updated
2021/12/16
More
Less

4-CHLORO-2-METHYL-5,6,7,8-TETRAHYDRO[1]BENZOTHIENO[2,3-D]PYRIMIDINE Chemical Properties,Usage,Production

Uses

4-chloro-2-methyl-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidine is a useful reactant for the synthesis of thieno[2,?3-?d]?pyrimidines and furo[2,?3-?d]?pyrimidines derivatives, for the use as c-?Met inhibitiors as a potential antitumor agents.

Synthesis

19819-15-9

81765-97-1

GENERAL METHOD: Different thieno[2,3-d]pyrimidin-4-one derivatives (6a-d or f-i) (1 eq.) were mixed with phosphorochloridic acid chloride (2.9 mL/mmol eq.) and heated to reflux for 8 hours. Upon completion of the reaction, the reaction mixture was cooled in an ice bath and neutralized by slow addition of saturated aqueous sodium bicarbonate solution. Subsequently, the reaction mixture was extracted with ethyl acetate (15 mL/millimolar equivalent), the organic layer was separated, dried with anhydrous magnesium sulfate and concentrated under reduced pressure. The crude product was purified by fast column chromatography with the eluent being n-hexane-ethyl acetate (initial ratio 100:0 v/v), which was gradually adjusted to n-hexane-ethyl acetate (85:15 v/v), unless otherwise stated.

References

[1] Chemical and Pharmaceutical Bulletin, 1982, vol. 30, # 1, p. 326 - 332
[2] European Journal of Medicinal Chemistry, 2016, vol. 123, p. 31 - 47
[3] Synthesis, 2001, # 14, p. 2119 - 2123

4-CHLORO-2-METHYL-5,6,7,8-TETRAHYDRO[1]BENZOTHIENO[2,3-D]PYRIMIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

4-CHLORO-2-METHYL-5,6,7,8-TETRAHYDRO[1]BENZOTHIENO[2,3-D]PYRIMIDINE Suppliers

Belgium 1 Canada 1 China 13 Germany 2 India 1 Ukraine 2 United Kingdom 2 United States 7 Global 29
A.J Chemicals
Tel
--
Fax
--
Email
sales@ajchem.in
Country
India
ProdList
6100
Advantage
58

81765-97-1, 4-CHLORO-2-METHYL-5,6,7,8-TETRAHYDRO[1]BENZOTHIENO[2,3-D]PYRIMIDINERelated Search:

4-CHLORO-2-METHYL-5,6,7,8-TETRAHYDRO[1]BENZOTHIENO[2,3-D]PYRIMIDINE 4-CHLORO-7-METHYL-5,6,7,8-TETRAHYDRO[1]BENZOTHIENO[2,3-D]PYRIMIDINE Pyrimidine 4-CHLORO-2-PYRIDIN-3-YL-5,6,7,8-TETRAHYDRO[1]BENZOTHIENO[2,3-D]PYRIMIDINE 4-CHLORO-7-METHYL-2-PYRIDIN-3-YL-5,6,7,8-TETRAHYDRO[1]BENZOTHIENO[2,3-D]PYRIMIDINE 4-CHLORO-2,7-DIMETHYL-5,6,7,8-TETRAHYDRO[1]BENZOTHIENO[2,3-D]PYRIMIDINE 4-CHLORO-7-METHYL-2-[(PHENYLTHIO)METHYL]-5,6,7,8-TETRAHYDRO[1]BENZOTHIENO[2,3-D]PYRIMIDINE 4-CHLORO-2-(MORPHOLIN-4-YLMETHYL)-5,6,7,8-TETRAHYDRO[1]BENZOTHIENO[2,3-D]PYRIMIDINE 4-CHLORO-2-([(4-CHLOROPHENYL)THIO]METHYL)-7-METHYL-5,6,7,8-TETRAHYDRO[1]BENZOTHIENO[2,3-D]PYRIMIDINE 2-([(4-BROMOPHENYL)THIO]METHYL)-4-CHLORO-7-METHYL-5,6,7,8-TETRAHYDRO[1]BENZOTHIENO[2,3-D]PYRIMIDINE 4-CHLORO-2-CHLOROMETHYL-5,6,7,8-TETRAHYDRO-BENZO[4,5]THIENO[2,3-D]PYRIMIDINE 4-CHLORO-2-(PIPERIDIN-1-YLMETHYL)-5,6,7,8-TETRAHYDRO[1]BENZOTHIENO[2,3-D]PYRIMIDINE 4-CHLORO-2-[[(4-CHLOROPHENYL)THIO]METHYL]-5,6,7,8-TETRAHYDRO[1]BENZOTHIENO[2,3-D]PYRIMIDINE 4-CHLORO-2-ETHYL-5,6,7,8-TETRAHYDRO[1]BENZOTHIENO[2,3-D]PYRIMIDINE 4-CHLORO-2-[(PHENYLTHIO)METHYL]-5,6,7,8-TETRAHYDRO[1]BENZOTHIENO[2,3-D]PYRIMIDINE AKOS 92590 2-[(E)-2-(4-BROMOPHENYL)VINYL]-4-CHLORO-5,6,7,8-TETRAHYDRO[1]BENZOTHIENO[2,3-D]PYRIMIDINE 2-(4-BROMO-PHENYLSULFANYLMETHYL)-4-CHLORO-5,6,7,8-TETRAHYDRO-BENZO[4,5]THIENO[2,3-D]PYRIMIDINE

  • IFLAB-BB F0307-0219
  • [1]BENZOTHIENO[2,3-D]PYRIMIDINE, 4-CHLORO-5,6,7,8-TETRAHYDRO-2-METHYL-
  • 4-CHLORO-2-METHYL-5,6,7,8-TETRAHYDRO[1]BENZOTHIENO[2,3-D]PYRIMIDINE
  • 4-CHLORO-2-METHYL-5,6,7,8-TETRAHYDROBENZO[4,5]THIENO[2,3-D]PYRIMIDINE
  • AKOS 92583
  • 4-Chloro-2-Methyl-5,6,7,8-tetrahydrobenzo[b]thieno[2,3-d]pyriMidine, 96%
  • 81765-97-1
  • C11H11ClN2S