ChemicalBook > CAS DataBase List > SB 221284

SB 221284

Product Name
SB 221284
CAS No.
196965-14-7
Chemical Name
SB 221284
Synonyms
SB 221284;5-(METHYLTHIO)-1-(3-PYRIDYLCARBAMOYL)-6-(TRIFLUOROMETHYL)INDOLINE;2,3-DIHYDRO-5-(METHYLTHIO)-N-3-PYRIDINYL-6-(TRIFLUOROMETHYL)-1H-INDOLE-1-CARBOXAMIDE;1H-Indole-1-carboxamide, 2,3-dihydro-5-(methylthio)-N-3-pyridinyl-6-(trifluoromethyl)-
CBNumber
CB4704933
Molecular Formula
C16H14F3N3OS
Formula Weight
353.36
MOL File
196965-14-7.mol
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SB 221284 Property

Melting point:
262-264 °C
Boiling point:
536.2±50.0 °C(Predicted)
Density 
1.43±0.1 g/cm3(Predicted)
storage temp. 
Store at +4°C
solubility 
DMSO: ~14 mg/mL, soluble
pka
13.13±0.20(Predicted)
form 
solid
color 
white
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Tocris
Product number
1379
Product name
SB221284
Purity
≥99%(HPLC)
Packaging
10
Price
$96
Updated
2021/12/16
Tocris
Product number
1379
Product name
SB221284
Purity
≥99%(HPLC)
Packaging
50
Price
$400
Updated
2021/12/16
TRC
Product number
S155028
Product name
SB221284
Packaging
5mg
Price
$170
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
BRS0000723
Product name
SB 221284
Purity
95.00%
Packaging
10MG
Price
$709.46
Updated
2021/12/16
ApexBio Technology
Product number
B6713
Product name
SB221284
Packaging
50mg
Price
$786
Updated
2021/12/16
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SB 221284 Chemical Properties,Usage,Production

Uses

SB 221284 is a potent, selective SR-2C/SR-2B antagonist.

Definition

ChEBI: SB 221284 is an indolyl carboxylic acid.

Biological Activity

Potent, selective 5-HT 2C/2B receptor antagonist. pK i values are 6.4, 7.9 and 8.6 for 5-HT 2A , 2B and 2C receptors respectively. Centrally active upon systemic administration in vivo .

in vivo

SB 221284 (0.1~1 mg/kg, i.p.) pre-treatment doses shows to block mCPP induced hypolocomotion, significantly enhances the hyperactivity induced by phencyclidine or MK-801[1].
SB 221284 (1 mg/kg, i.p.) significantly enhances the magnitude and duration of the increase induced by phencyclidine[1]

Animal Model:Male Sprague Dawley rats (250–360 g)[1]
Dosage:0.1~1 mg/kg
Administration:I.p.
Result:Pre-treatment doses showed to block mCPP induced hypolocomotion, significantly enhanced the hyperactivity induced by phencyclidine or MK-801.
Animal Model:Male Sprague Dawley rats (250–360 g)[1]
Dosage:1 mg/kg
Administration:I.p.
Result:Significantly enhanced the magnitude and duration of the increase induced by phencyclidine.

IC 50

5-HT2A Receptor: 6.4 (pKi); 5-HT2B Receptor: 7.9 (pKi); 5-HT2C Receptor: 8.6 (pKi)

SB 221284 Preparation Products And Raw materials

Raw materials

Preparation Products

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SB 221284 Suppliers

China 21 Germany 1 Switzerland 1 United Kingdom 4 United States 10 USA 1 Global 38
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15838
Advantage
69
Energy Chemical
Tel
021-58432009 400-005-6266
Fax
021-58436166
Email
marketing1@energy-chemical.com
Country
China
ProdList
44894
Advantage
58
TargetMol Chemicals Inc.
Tel
4008200310
Email
marketing@tsbiochem.com
Country
China
ProdList
24961
Advantage
58
Nantong QuanYi Biotechnology Co., Ltd
Tel
0513-66337626 18051384581
Email
sales@chemhifuture.com
Country
China
ProdList
5929
Advantage
58
Shanghai Fine Biotech Co.，Ltd
Tel
18221172427
Email
sale@fine-biotech.com
Country
China
ProdList
2760
Advantage
58
Santa Cruz Biotechnology Inc
Tel
021-60936350
Email
scbt@scbt.com
Country
China
ProdList
6594
Advantage
58
Guangzhou Weisheng Biotechnology Co., Ltd.
Tel
17765667235
Country
CHINA
ProdList
129
Advantage
58
Guangzhou Junuo Biotechnology Co., Ltd.
Tel
13432975901
Country
CHINA
ProdList
132
Advantage
58
Absin Bioscience Inc.
Tel
--
Fax
--
Email
chenjw@absin.cn
Country
CHINA
ProdList
6208
Advantage
58
Beijing Taize Jiaye Technology Development Co., Ltd.
Tel
--
Fax
--
Country
CHINA
ProdList
6050
Advantage
58
Shanghai Haoyang Biological Technology Co., Ltd.
Tel
--
Fax
--
Email
596799915@QQ.COM
Country
CHINA
ProdList
2905
Advantage
58
Xiamen Huijia Biological Technology Co., Ltd.
Tel
--
Fax
--
Country
CHINA
ProdList
6973
Advantage
58
Shanghai Hao Biological Technology Co., Ltd.
Tel
--
Fax
--
Email
shxiyuanbio@163.com
Country
CHINA
ProdList
6906
Advantage
58
Qingdao Jieshikang Biotechnology Co., Ltd.
Tel
--
Fax
--
Email
jskangchina@163.com
Country
CHINA
ProdList
4980
Advantage
58
Shanghai Weiwei Biological Technology Co., Ltd.
Tel
--
Fax
--
Email
sales@wheybio.com
Country
CHINA
ProdList
4398
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58
Shanghai Chaoyan Biotechnology Co., Ltd.
Tel
--
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Email
471161314@qq.com
Country
CHINA
ProdList
6210
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58
Beijing Bolide Biotechnology Co., Ltd.
Tel
--
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Email
1985563437@qq.com
Country
CHINA
ProdList
6525
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58
Shanghai Yuda Industrial Co., Ltd.
Tel
--
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Email
lucy@runwelltac.com
Country
CHINA
ProdList
6448
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58
Beijing Fubo Biotechnology Co., Ltd.
Tel
--
Fax
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Email
info@f-biology.com
Country
CHINA
ProdList
6170
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58
Guangzhou WeiBo Chemical Co., Ltd.
Tel
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Email
weibochem@163.com
Country
China
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6187
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67
Shanghai PI Chemicals Ltd.
Tel
--
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--
Email
sales@pipharm.com
Country
China
ProdList
6344
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56

196965-14-7, SB 221284Related Search:

2-(4-TRIFLUOROMETHYL-PHENYL)-ETHYLAMINE 2-(TRIFLUOROMETHYL)THIOPHENOL 6-METHYL-2,3-DIHYDRO-1H-INDOLE 6-(Trifluoromethyl)indoline SB 221284 4-METHYLTHIO-3-(TRIFLUOROMETHYL)ANILINE

  • 5-(METHYLTHIO)-1-(3-PYRIDYLCARBAMOYL)-6-(TRIFLUOROMETHYL)INDOLINE
  • 2,3-DIHYDRO-5-(METHYLTHIO)-N-3-PYRIDINYL-6-(TRIFLUOROMETHYL)-1H-INDOLE-1-CARBOXAMIDE
  • SB 221284
  • 1H-Indole-1-carboxamide, 2,3-dihydro-5-(methylthio)-N-3-pyridinyl-6-(trifluoromethyl)-
  • 196965-14-7
  • C16H14N3F3OS