3-Amino-3-(4-fluorophenyl)propanoic acid
Uses- Product Name
- 3-Amino-3-(4-fluorophenyl)propanoic acid
- CAS No.
- 325-89-3
- Chemical Name
- 3-Amino-3-(4-fluorophenyl)propanoic acid
- Synonyms
- 3-Amino-3-(4-fL;TIMTEC-BB SBB003727;RARECHEM AK HC T330;3-AMINO-(4-FLUOROPHENYL;DL-BETA-(P-FLUOROPHENYL)ALANINE;3-(4-FLUOROPHENYL)-BETA-ALANINE;3-(p-fluorophenyl)-DL-beta-alanine;3-Amino-3-(4-fluorophenyl)propionic;1-(2,5-diethylphenyl)propan-1-amine;3-AMINO-(4-FLUOROPHENYL)PROPIONIC ACID,&
- CBNumber
- CB4707853
- Molecular Formula
- C9H10FNO2
- Formula Weight
- 183.18
- MOL File
- 325-89-3.mol
3-Amino-3-(4-fluorophenyl)propanoic acid Property
- Melting point:
- 224-228 °C (dec.) (lit.)
- Boiling point:
- 308.8±32.0 °C(Predicted)
- Density
- 1.289±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- form
- powder to crystal
- pka
- 3.66±0.10(Predicted)
- color
- White to Almost white
- optical activity
- 0.20°(C=0.55g/100mL, HCL, 20°C, 589nm)
- BRN
- 3258498
- InChIKey
- CPGFMWPQXUXQRX-UHFFFAOYSA-N
- CAS DataBase Reference
- 325-89-3(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- 573418
- Product name
- 3-Amino-3-(4-fluorophenyl)propionic acid
- Purity
- 97%
- Packaging
- 1g
- Price
- $50.4
- Updated
- 2023/06/20
- Product number
- A2430
- Product name
- 3-Amino-3-(4-fluorophenyl)propionic Acid
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 1g
- Price
- $239
- Updated
- 2023/06/20
- Product number
- A634645
- Product name
- 3-Amino-3-(4-fluorophenyl)propanoicAcid
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 008797
- Product name
- 3-Amino-3-(4-fluorophenyl)propanoic acid
- Purity
- 97%
- Packaging
- 1g
- Price
- $30
- Updated
- 2021/12/16
- Product number
- 008797
- Product name
- 3-Amino-3-(4-fluorophenyl)propanoic acid
- Purity
- 97%
- Packaging
- 5g
- Price
- $90
- Updated
- 2021/12/16
3-Amino-3-(4-fluorophenyl)propanoic acid Chemical Properties,Usage,Production
Uses
3-Amino-3-(4-fluorophenyl)propionic acid is a carboxylic acid derivative that can be used as a pharmaceutical intermediate for pharmaceutical synthesis and experimental research.
Chemical Properties
White powder
Synthesis
141-82-2
459-57-4
325-89-3
To a 150 mL round bottom flask was added 30.5 g (0.25 mol) of 4-fluorobenzaldehyde, 25.6 g (0.25 mol) of malonic acid and 28.4 g (0.37 mol) of ammonium acetate dissolved in ethanol. The reaction mixture was heated to 75-80°C and the reaction was stirred under reflux conditions for 8 hours. After completion of the reaction, the mixture was cooled to room temperature and stirring was continued for 1 hour. Subsequently, the precipitate was collected by filtration and dried under reduced pressure at 45°C to give 28.3 g of 3-amino-3-(4-fluorophenyl)propionic acid (racemic mixture) in 62.8% yield (calculated based on 4-fluorobenzaldehyde), the product was a white powder. The physical properties of 3-amino-3-(4-fluorophenyl)propionic acid (racemic mixture) were as follows: 1H-NMR (δ, ppm, D2O): 2.49 (dd, 1H, J = 17.1, 6.8 Hz), 2.62 (dd, 1H, J = 17.1, 7.8 Hz), 4.20 (dd, 1H, J = 7.8, 6.8 Hz), 6.58-6.62 (m, 2H), 6.88-6.91 (m, 1H) 13C-NMR (δ, ppm, D2O): 37.1, 50.5, 115.5, 115.8, 128.9, 130.4, 172.6 MS (EI) m/z: 183 (M+) MS (CI, i-C4H10) m/z: 184 (MH+)
References
[1] Chemical Communications, 2011, vol. 47, # 20, p. 5894 - 5896
[2] Beilstein Journal of Organic Chemistry, 2013, vol. 9, p. 260 - 264
[3] Journal of Medicinal Chemistry, 2001, vol. 44, # 12, p. 1938 - 1950
[4] European Journal of Medicinal Chemistry, 2018, vol. 156, p. 252 - 268
[5] European Journal of Medicinal Chemistry, 1992, vol. 27, # 9, p. 961 - 965
3-Amino-3-(4-fluorophenyl)propanoic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-Amino-3-(4-fluorophenyl)propanoic acid manufacturers
- Product
- 3-Amino-3-(4-fluorophenyl)propionic acid 325-89-3
- Price
- US $1.10-9.90/KG
- Min. Order
- 1KG
- Purity
- 99%min
- Supply Ability
- 100KG
- Release date
- 2025-08-20
- Product
- 3-Amino-3-(4-fluorophenyl)propanoic acid 325-89-3
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10
- Product
- 3-Amino-3-(4-fluorophenyl)propanoic acid 325-89-3
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-09