ChemicalBook > CAS DataBase List > 2,5-DIBROMOTHIAZOLE

2,5-DIBROMOTHIAZOLE

Product Name: 2,5-DIBROMOTHIAZOLE
CAS No.: 4175-78-4
Chemical Name: 2,5-DIBROMOTHIAZOLE
Synonyms: DibromoThiazole;2,5-Dibromo-1,3-thiazole;TZ-2Br;NSC 222407;2,5-Dibormothiazole;2,5-DIBROMOTHIAZOLE;2,5-Dibromothiazole>Thiazole, 2,5-dibroMo-;2,5-Dibromothiazole,97%;2,5-DIBROMOTHIAZOLE 95%
CBNumber: CB4709413
Molecular Formula: C3HBr2NS
Formula Weight: 242.92
MOL File: 4175-78-4.mol

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2,5-DIBROMOTHIAZOLE Property

Melting point:: 45-49 °C (lit.)
Boiling point:: 242.8±13.0 °C(Predicted)
Density: 2.324±0.06 g/cm3(Predicted)
Flash point:: 110 °C
storage temp.: Inert atmosphere,Store in freezer, under -20°C
solubility: soluble in Methanol
pka: -0.88±0.10(Predicted)
form: Crystalline Powder
color: White to brown
InChI: InChI=1S/C3HBr2NS/c4-2-1-6-3(5)7-2/h1H
InChIKey: XIBIQFJKUZZLLX-UHFFFAOYSA-N
SMILES: S1C(Br)=CN=C1Br
CAS DataBase Reference: 4175-78-4(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
Hazard Note: Harmful
HS Code: 29341000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 524182
Product name: 2,5-Dibromothiazole
Purity: 97%
Packaging: 5g
Price: $55.72
Updated: 2025/07/31

TCI Chemical

Product number: D3960
Product name: 2,5-Dibromothiazole
Purity: >97.0%(GC)
Packaging: 5g
Price: $93
Updated: 2025/07/31

TRC

Product number: D426055
Product name: 2,5-Dibromothiazole
Packaging: 25g
Price: $1055
Updated: 2021/12/16

TRC

Product number: D426055
Product name: 2,5-Dibromothiazole
Packaging: 2.5g
Price: $130
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD21598
Product name: 2,5-Dibromothiazole
Packaging: 50g
Price: $160
Updated: 2021/12/16

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2,5-DIBROMOTHIAZOLE Chemical Properties,Usage,Production

Chemical Properties

White to brown crystalline powder

Uses

Used as a building block in material science.1,2

Uses

2,5-Dibromothiazole is used in the preparation of arylthiazolylpiperidine derivatives and analogs for use as survival motor neuron (SMN) protein production modulators.

Synthesis

3034-22-8

4175-78-4

2-Amino-5-bromothiazole (5.5 g, 30.72 mmol) was used as starting material and dissolved in acetonitrile (50 mL). Copper (II) bromide (3.43 g, 15.36 mmol) and isoamyl nitrite (4.9 mL, 36.87 mmol) were added sequentially. The reaction mixture was heated at 60 °C for 4 h with stirring. After completion of the reaction, the volatile solvent was removed by rotary evaporator. The residue was diluted with distilled water (50 mL) and subsequently extracted with ethyl acetate (25 mL x 2). The organic phases were combined, washed with saturated saline (50 mL) and dried over anhydrous sodium sulfate. The organic phase was concentrated under reduced pressure to give the crude product. The crude product was purified by silica gel column chromatography (60-120 mesh, eluent 10% ethyl acetate in hexane solution) to afford the target compound 2,5-dibromothiazole (5.05 g, yield 68%) as a yellow liquid. m/z 243.6 [M+2] by LCMS.

References

[1] Patent: WO2015/88045, 2015, A1. Location in patent: Paragraph 0260
[2] Patent: US2017/8885, 2017, A1. Location in patent: Paragraph 0672-0673
[3] Bulletin de la Societe Chimique de France, 1962, p. 2075 - 2078
[4] Journal of Organic Chemistry, 2017, vol. 82, # 11, p. 5947 - 5951

2,5-DIBROMOTHIAZOLE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 2,5-DIBROMOTHIAZOLE manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: 2,5-Dibromothiazole 4175-78-4
Price: US $30.00-10.00/KG
Min. Order: 50KG
Purity: 99%
Supply Ability: 500000kg
Release date: 2024-11-04

Henan Fengda Chemical Co., Ltd

Product: 2,5-DIBROMOTHIAZOLE 4175-78-4
Price: US $35.00-1.10/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-04-19

Hebei Zhanyao Biotechnology Co. Ltd

Product: 2,5-Dibromothiazole 4175-78-4
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20 tons
Release date: 2021-10-12

4175-78-4, 2,5-DIBROMOTHIAZOLERelated Search:

2-Cyclopenten-1-one 2-CHLORO-5-NITROBENZENESULFONAMIDE Methyl 3-cyano-4-fluorobenzoate 2,4-DIBROMOTHIAZOLE 98%,2,4-DIBROMOTHIAZOLE, 97+%,2,4-Dibromothiazole ,98%,2,4-DIBROMOTHIAZOLE 5-Thiazolecarboxylic acid, 2,4-dibromo- 2,4-Dibromothiazole-5-carboxaldehyde 2,4-Dibromothiazole-5-methanol 2,5-DIBROMOTHIAZOLE 2,5-DIBROMO-THIAZOLE-4-CARBOXYLIC ACID ETHYL ESTER 2,5-DIBROMO-THIAZOLE-4-CARBOXYLIC ACID 2,5-DIBROMO-4-METHYLTHIAZOLE 4-CHLOROMETHYL-2,5-DIBROMOTHIAZOLE 2,5-DIBROMO-4-(HYDROXYMETHYL)THIAZOLE 2,5-DIBROMOTHIAZOLE-4-CARBOXYLIC ACID METHYL ESTER, 95+% ETHYL 2,5-DIBROMOTHIAZOLE-4-CARBOXYLATE 2,4-Dibromothiazole-5-carboxylic acid 5-CYANO-2,4-DIBROMOTHIAZOLE 2,5-DIBROMOTHIAZOLE-4-CARBOXYLIC ACID METHYL ESTER

2,5-Dibromo-1,3-thiazole

2,5-DIBROMOTHIAZOLE

2,5-DIBROMOTHIAZOLE 95%

2,5-Dibromothiazole,97%

Thiazole, 2,5-dibroMo-

NSC 222407

2,5-Dibormothiazole

DibromoThiazole

TZ-2Br

2,5-Dibromothiazole&gt

4175-78-4

Building Blocks

Heterocyclic Building Blocks

Halogenated Heterocycles

Thiazoles

Building Blocks

C3 to C7

Chemical Synthesis

Halogenated Heterocycles

Heterocyclic Building Blocks

alkyl bromide

Building Blocks

Halogenated Heterocycles

Heterocyclic Building Blocks

ThiazolesHeterocyclic Building Blocks

Heterocyclic Compounds

Thiazoles

Sulphur Derivatives