2,4-Dibromothiazole

Product Name: 2,4-Dibromothiazole
CAS No.: 4175-77-3
Chemical Name: 2,4-Dibromothiazole
Synonyms: 2,4-Dibromo-1,3-thiazole;2,4-BROMOTHIAZOLE;2,4-Dibrmothiazole;2,4-dibormothiazole;2,4-DIBROMOTHIAZOLE;2,4-Dibromothiazole>Thiazole, 2,4-dibroMo-;2,4-DIBROMOTHIAZOLE 98%;2,4-Dibromothiazole ,98%;2,4-DIBROMOTHIAZOLE, 97+%
CBNumber: CB0179775
Molecular Formula: C3HBr2NS
Formula Weight: 242.92
MOL File: 4175-77-3.mol

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2,4-Dibromothiazole Property

Melting point:: 80-84 °C
Boiling point:: 242.8±13.0 °C(Predicted)
Density: 2.324±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: soluble in Methanol
form: powder to crystal
pka: -1.93±0.10(Predicted)
color: White to Light yellow
InChI: InChI=1S/C3HBr2NS/c4-2-1-7-3(5)6-2/h1H
InChIKey: MKEJZKKVVUZXIS-UHFFFAOYSA-N
SMILES: S1C=C(Br)N=C1Br
CAS DataBase Reference: 4175-77-3(CAS DataBase Reference)

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Safety

Hazard Codes: Xn,Xi
Risk Statements: 22-37/38-41-36/37/38
Safety Statements: 26-39-36-37/39
WGK Germany: 3
Hazard Note: Harmful
HazardClass: IRRITANT, KEEP COLD
HS Code: 29349990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 677914
Product name: 2,4-Dibromothiazole
Purity: 97%
Packaging: 5g
Price: $27.79
Updated: 2025/07/31

Sigma-Aldrich

Product number: 677914
Product name: 2,4-Dibromothiazole
Purity: 97%
Packaging: 1g
Price: $25
Updated: 2023/06/20

TCI Chemical

Product number: D3667
Product name: 2,4-Dibromothiazole
Purity: >98.0%(GC)
Packaging: 1g
Price: $20
Updated: 2025/07/31

TCI Chemical

Product number: D3667
Product name: 2,4-Dibromothiazole
Purity: >98.0%(GC)
Packaging: 5g
Price: $43
Updated: 2025/07/31

TCI Chemical

Product number: D3667
Product name: 2,4-Dibromothiazole
Purity: >98.0%(GC)
Packaging: 25g
Price: $161
Updated: 2025/07/31

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2,4-Dibromothiazole Chemical Properties,Usage,Production

Chemical Properties

Off-white crystalline powder

Uses

2,4-Dibromothiazole is an intermediate used in the preparation of various 2,4-disubstituted thiazole derivatives with biologically active properties such as survival motor neuron (SMN) protein modula tors.

Uses

2,4-Dibromothiazole is applied as a building block in a synthesis of Melithiazole C employing a highly (E)-selective cross-metathesis between the derived 4-vinylthiazole and a dienote side-chain. It is also used as an intermediate in the preparation of various 2,4-disubstituted thiazole derivatives with biologically active properties such as survival motor neuron (SMN) protein modulators.

Uses

Building block in a synthesis of Melithiazole C employing a highly (E)-selective cross-metathesis between the derived 4-vinylthiazole and a dienote side-chain.

Synthesis

2295-31-0

4175-77-3

General procedure for the synthesis of 2,4-dibromothiazoles from 2,4-thiazolidinediones: Example 41: Preparation of 2-amino-3-methyl-5-(3-pyrimidin-5-ylphenyl)-5-(1,3-thiazol-4-yl)-3,5-dihydro-4H-imidazol-4-one Step a) Preparation of compound 2 A mixture of 2,4-thiazolidinedione 1 (2.28 g, 19.5 mmol) with phosphorus tribromide (25.0 g, 87.0 mmol) was heated at 130°C for 30 min and subsequently cooled to room temperature. The reaction mixture was diluted with ice water (300 mL) and neutralized by batchwise addition of solid sodium carbonate. After neutralization was complete, the mixture was extracted with dichloromethane (3 x 150 mL). The organic layers were combined, dried over anhydrous sodium sulfate, filtered and concentrated. The residue was purified by fast column chromatography (silica gel, elution gradient: 0:100 to 5:95 ethyl acetate/hexane) to afford compound 2 (3.34 g, 71%) as light yellow crystals.1H NMR (500 MHz, CDCl3) δ 7.21 (s, 1H).

References

[1] Journal of Organic Chemistry, 2006, vol. 71, # 10, p. 3754 - 3761
[2] Synthesis, 2012, vol. 44, # 7, p. 1026 - 1029
[3] Journal of Materials Chemistry C, 2017, vol. 5, # 45, p. 11927 - 11936
[4] Patent: US2007/4786, 2007, A1. Location in patent: Page/Page column 21
[5] Tetrahedron, 2006, vol. 62, # 38, p. 9017 - 9037

2,4-Dibromothiazole Preparation Products And Raw materials

Raw materials

Phosphorus oxybromide PETROLEUM ETHER

Preparation Products

4-METHOXY-2-MORPHOLIN-4-YL-THIAZOLE-5-CARBALDEHYDE

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2,4-Dibromothiazole Suppliers

Americas 1 Belgium 1 Canada 2 China 282 Europe 1 France 1 Germany 5 India 22 Japan 1 Slovakia 2 Switzerland 1 Ukraine 2 United Kingdom 17 United States 41 Global 379

Nanjing Chemrui Pharmtech Co., Ltd.

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J & K SCIENTIFIC LTD.

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INTATRADE GmbH

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ChemFuture PharmaTech (Jiangsu) Ltd

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TCI (Shanghai) Development Co., Ltd.

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Energy Chemical

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View Lastest Price from 2,4-Dibromothiazole manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: 2,4-Dibromothiazole 4175-77-3
Price: US $1.60-6.60/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2025-06-19

Hebei Fengjia New Material Co., Ltd

Product: 2,4-Dibromothiazole 4175-77-3
Price: US $67.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 100000
Release date: 2024-08-16

Hebei Chuanghai Biotechnology Co., Ltd

Product: 2,4-Dibromothiazole 4175-77-3
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 500000kg
Release date: 2024-10-31

4175-77-3, 2,4-DibromothiazoleRelated Search:

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2,4-Dibromo-1,3-thiazole

2,4-DIBROMOTHIAZOLE

2,4-BROMOTHIAZOLE

2,4-DIBROMOTHIAZOLE 98%

2,4-Dibromothiazole ,98%

2,4-DIBROMOTHIAZOLE, 97+%

2,4-Dibrmothiazole

2,4-dibormothiazole

Thiazole, 2,4-dibroMo-

2,4-Dibromothiazole&gt

TIANFU-CHEM 2,4-Dibromothiazole 4175-77-3

4175-77-3

C3HBr2NS

C3HNBr2S

Building Blocks

Halogenated Heterocycles

Heterocyclic Building Blocks

ThiazolesHeterocyclic Building Blocks

Halogenated

Organohalides

Thiazole

Thiazoles

blocks

Bromides