2-Bromothiazole
Description Referrence- Product Name
- 2-Bromothiazole
- CAS No.
- 3034-53-5
- Chemical Name
- 2-Bromothiazole
- Synonyms
- 2-BROMO-1,3-THIAZOLE;CL028;TZ-Br;NSC 91532;2-Bromthiazol;2-bromo-thiazol;2-BROMOTHIAZOLE;2-BROMOTHIOAZOLE;Thiazole, 2-bromo-;2-THIAZOLYL BROMIDE
- CBNumber
- CB1739860
- Molecular Formula
- C3H2BrNS
- Formula Weight
- 164.02
- MOL File
- 3034-53-5.mol
2-Bromothiazole Property
- Melting point:
- 171 C
- Boiling point:
- 171 °C (lit.)
- Density
- 1.82 g/mL at 25 °C (lit.)
- refractive index
- n20/D 1.593(lit.)
- Flash point:
- 146 °F
- storage temp.
- 2-8°C
- solubility
- Chloroform, Dichloromethane
- pka
- 0.84±0.10(Predicted)
- form
- Liquid
- color
- Clear colorless to orange-brown
- Specific Gravity
- 1.836
- Water Solubility
- insoluble
- BRN
- 105724
- InChIKey
- RXNZFHIEDZEUQM-UHFFFAOYSA-N
- CAS DataBase Reference
- 3034-53-5(CAS DataBase Reference)
- NIST Chemistry Reference
- Thiazole, 2-bromo-(3034-53-5)
- EPA Substance Registry System
- Thiazole, 2-bromo- (3034-53-5)
Safety
- Hazard Codes
- Xi,F
- Risk Statements
- 36/37/38
- Safety Statements
- 23-24/25-36-26
- RIDADR
- 1993
- WGK Germany
- 3
- TSCA
- Yes
- HazardClass
- IRRITANT, FLAMMABLE
- HS Code
- 29341000
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H227Combustible liquid
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P403+P235Store in a well-ventilated place. Keep cool.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 160474
- Product name
- 2-Bromothiazole
- Purity
- 98%
- Packaging
- 5g
- Price
- $54.9
- Updated
- 2024/03/01
- Product number
- 160474
- Product name
- 2-Bromothiazole
- Purity
- 98%
- Packaging
- 25g
- Price
- $102
- Updated
- 2024/03/01
- Product number
- B1280
- Product name
- 2-Bromothiazole
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $79
- Updated
- 2024/03/01
- Product number
- B1280
- Product name
- 2-Bromothiazole
- Purity
- >98.0%(GC)
- Packaging
- 250g
- Price
- $464
- Updated
- 2024/03/01
- Product number
- A14838
- Product name
- 2-Bromothiazole, 99%
- Packaging
- 10g
- Price
- $59.65
- Updated
- 2024/03/01
2-Bromothiazole Chemical Properties,Usage,Production
Description
It is usually used as the intermediate or raw material to produce various products in the organic synthesis and pharmaceutical industry, such as 2-acetylthiazole, antibiotics, and anticholinergic drugs. Specifically, this chemical can act as the raw material to produce camalexin through reaction with indolylmagnesium iodide.1 Moreover, this substance has been selected as the reactant to prepare the thiazole Grignard reagents and thiazolyllithium compounds, which can be converted into thiazole-2-carboxylic acid via a halogen-metal exchange reaction.2, 3 In addition, 2-bromothiazole has been used to synthesize N-aryl aminothiazoles, which are found to function as the inhibitors of cyclin-dependent kinases.4 Besides, this compound may be involved in the synthesis of ethynylthiazoles that exhibits a desirable anti-inflammatory activity.5
Referrence
- Ayer, W. A.; Craw, P. A.; Ma, Y. T.; Miao, S. C., SYNTHESIS OF CAMALEXIN AND RELATED PHYTOALEXINS. Tetrahedron 1992, 48, 2919-2924.
- Kurkjy, R. P.; Brown, E. V., THE PREPARATION OF THIAZOLE GRIGNARD REAGENTS AND THIAZOLYLLITHIUM COMPOUNDS. J. Am. Chem. Soc. 1952, 74, 6260-6262.
- Beyerman, H. C.; Berben, P. H.; Bontekoe, J. S., THE SYNTHESIS OF THIAZOLE-2-CARBOXYLIC AND OF THIAZOLE-5-CARBOXYLIC ACID VIA A HALOGEN-METAL EXCHANGE REACTION. Recl. Trav. Chim. Pays-Bas-J. Roy. Neth. Chem. Soc. 1954, 73, 325-332.
- Misra, R. N.; Xiao, H. Y.; Williams, D. K.; Kim, K. S.; Lu, S. F.; Keller, K. A.; Mulheron, J. G.; Batorsky, R.; Tokarski, J. S.; Sack, J. S.; Kimball, D.; Lee, F. Y.; Webster, K. R., Synthesis and biological activity of N-aryl-2-aminothiazoles: potent pan inhibitors of cyclin-dependent kinases. Bioorg. Med. Chem. Lett. 2004, 14, 2973-2977.
- Geronikaki, A.; Vasilevsky, S.; Hadjipavlou-Litina, D.; Lagunin, A.; Poroikov, B. V., Synthesis and anti-inflammatory activity of ethynylthiazoles. Khim. Geterotsiklicheskikh Soedin. 2006, 769-774.
Chemical Properties
Colourless Liquid
Uses
Aryl halide used to N-arylate 5- and 7-azaindoles.1 Copper-catalyzed cyanation provides 2-cyanothiazole.2
Uses
2-Bromothiazole, is intended used for research purpose only. It is also used as Aryl halide which are used to N-arylate 5- and 7-azaindoles. Copper-catalyzed cyanation provides 2-cyanothiazole
Uses
2-Bromothiazole is a heterocyclic S compound to induce base-pair substitution and having mutagenic activity.
2-Bromothiazole Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-Bromothiazole manufacturers
- Product
- 2-Bromothiazole 3034-53-5
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 10ton
- Release date
- 2024-07-22
- Product
- 2-Bromothiazole 3034-53-5
- Price
- US $1.00/Kg
- Min. Order
- 1Kg
- Purity
- 98%
- Supply Ability
- 20T
- Release date
- 2024-07-18
- Product
- 2-Bromothiazole 3034-53-5
- Price
- US $32.00-1.10/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-04-22