2-Bromothiazole

Description Referrence

Product Name: 2-Bromothiazole
CAS No.: 3034-53-5
Chemical Name: 2-Bromothiazole
Synonyms: 2-BROMO-1,3-THIAZOLE;CL028;TZ-Br;NSC 91532;2-Bromthiazol;2-bromo-thiazol;2-BROMOTHIAZOLE;2-BROMOTHIOAZOLE;Thiazole, 2-bromo-;2-THIAZOLYL BROMIDE
CBNumber: CB1739860
Molecular Formula: C3H2BrNS
Formula Weight: 164.02
MOL File: 3034-53-5.mol

More

Less

2-Bromothiazole Property

Melting point:: 171 C
Boiling point:: 171 °C (lit.)
Density: 1.82 g/mL at 25 °C (lit.)
refractive index: n20/D 1.593(lit.)
Flash point:: 146 °F
storage temp.: 2-8°C
solubility: Chloroform, Dichloromethane
pka: 0.84±0.10(Predicted)
form: Liquid
color: Clear colorless to orange-brown
Specific Gravity: 1.836
Water Solubility: insoluble
BRN: 105724
InChIKey: RXNZFHIEDZEUQM-UHFFFAOYSA-N
CAS DataBase Reference: 3034-53-5(CAS DataBase Reference)
NIST Chemistry Reference: Thiazole, 2-bromo-(3034-53-5)
EPA Substance Registry System: Thiazole, 2-bromo- (3034-53-5)

More

Less

Safety

Hazard Codes: Xi,F
Risk Statements: 36/37/38
Safety Statements: 23-24/25-36-26
RIDADR: 1993
WGK Germany: 3
TSCA: Yes
HazardClass: IRRITANT, FLAMMABLE
HS Code: 29341000

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H227Combustible liquid

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P403+P235Store in a well-ventilated place. Keep cool.

P405Store locked up.

P501Dispose of contents/container to..…

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 160474
Product name: 2-Bromothiazole
Purity: 98%
Packaging: 5g
Price: $54.9
Updated: 2024/03/01

Sigma-Aldrich

Product number: 160474
Product name: 2-Bromothiazole
Purity: 98%
Packaging: 25g
Price: $102
Updated: 2024/03/01

TCI Chemical

Product number: B1280
Product name: 2-Bromothiazole
Purity: >98.0%(GC)
Packaging: 25g
Price: $79
Updated: 2024/03/01

TCI Chemical

Product number: B1280
Product name: 2-Bromothiazole
Purity: >98.0%(GC)
Packaging: 250g
Price: $464
Updated: 2024/03/01

Alfa Aesar

Product number: A14838
Product name: 2-Bromothiazole, 99%
Packaging: 10g
Price: $59.65
Updated: 2024/03/01

More

Less

2-Bromothiazole Chemical Properties,Usage,Production

Description

It is usually used as the intermediate or raw material to produce various products in the organic synthesis and pharmaceutical industry, such as 2-acetylthiazole, antibiotics, and anticholinergic drugs. Specifically, this chemical can act as the raw material to produce camalexin through reaction with indolylmagnesium iodide.¹Moreover, this substance has been selected as the reactant to prepare the thiazole Grignard reagents and thiazolyllithium compounds, which can be converted into thiazole-2-carboxylic acid via a halogen-metal exchange reaction.^{2, 3} In addition, 2-bromothiazole has been used to synthesize N-aryl aminothiazoles, which are found to function as the inhibitors of cyclin-dependent kinases.⁴Besides, this compound may be involved in the synthesis of ethynylthiazoles that exhibits a desirable anti-inflammatory activity.⁵

Referrence

Ayer, W. A.; Craw, P. A.; Ma, Y. T.; Miao, S. C., SYNTHESIS OF CAMALEXIN AND RELATED PHYTOALEXINS. Tetrahedron 1992, 48, 2919-2924.
Kurkjy, R. P.; Brown, E. V., THE PREPARATION OF THIAZOLE GRIGNARD REAGENTS AND THIAZOLYLLITHIUM COMPOUNDS. J. Am. Chem. Soc. 1952, 74, 6260-6262.
Beyerman, H. C.; Berben, P. H.; Bontekoe, J. S., THE SYNTHESIS OF THIAZOLE-2-CARBOXYLIC AND OF THIAZOLE-5-CARBOXYLIC ACID VIA A HALOGEN-METAL EXCHANGE REACTION. Recl. Trav. Chim. Pays-Bas-J. Roy. Neth. Chem. Soc. 1954, 73, 325-332.
Misra, R. N.; Xiao, H. Y.; Williams, D. K.; Kim, K. S.; Lu, S. F.; Keller, K. A.; Mulheron, J. G.; Batorsky, R.; Tokarski, J. S.; Sack, J. S.; Kimball, D.; Lee, F. Y.; Webster, K. R., Synthesis and biological activity of N-aryl-2-aminothiazoles: potent pan inhibitors of cyclin-dependent kinases. Bioorg. Med. Chem. Lett. 2004, 14, 2973-2977.
Geronikaki, A.; Vasilevsky, S.; Hadjipavlou-Litina, D.; Lagunin, A.; Poroikov, B. V., Synthesis and anti-inflammatory activity of ethynylthiazoles. Khim. Geterotsiklicheskikh Soedin. 2006, 769-774.

Chemical Properties

Colourless Liquid

Uses

Aryl halide used to N-arylate 5- and 7-azaindoles.1 Copper-catalyzed cyanation provides 2-cyanothiazole.2

Uses

2-Bromothiazole, is intended used for research purpose only. It is also used as Aryl halide which are used to N-arylate 5- and 7-azaindoles. Copper-catalyzed cyanation provides 2-cyanothiazole

Uses

2-Bromothiazole is a heterocyclic S compound to induce base-pair substitution and having mutagenic activity.

2-Bromothiazole Preparation Products And Raw materials

Raw materials

Phosphoric acid Nitric acid

Preparation Products

THIAZOLE-2-CARBOXYLIC ACID 2-Bromo-5-fomylthiazole 1,3-Thiazole-2-carbonyl chloride Thiazole-5-carboxylic acid 5-Bromothiazole

More

Less

2-Bromothiazole Suppliers

Americas 1 Belgium 4 Canada 2 China 304 Europe 2 Germany 10 India 32 Japan 5 Russia 1 Slovakia 1 South Korea 2 Switzerland 4 Ukraine 2 United Kingdom 33 United States 64 Global 467

INTATRADE GmbH

Tel: +49 3493/605464
Fax: +49 3493/605470
Email: sales@intatrade.de
Country: Germany
ProdList: 3572
Advantage: 66

Synchem OHG

Tel: +49 5662 408730
Fax: +49 5662 4087320
Email: info@synchem.de
Country: Germany
ProdList: 4705
Advantage: 70

Merck Millipore

Tel: --
Fax: --
Email: ccc@merckgroup.com
Country: Germany
ProdList: 2008
Advantage: 58

Alfa Aesar, Thermo Fisher Scientific

Tel: --
Fax: --
Email: es@alfa.com
Country: Germany
ProdList: 5123
Advantage: 58

CHEMOS GmbH & Co. KG

Tel: --
Fax: --
Email: chemos@chemos.de
Country: Germany
ProdList: 6727
Advantage: 58

SYNTHON Chemicals GmbH & Co. KG

Tel: --
Fax: --
Email: synthon@synthon-chemicals.com
Country: Germany
ProdList: 2000
Advantage: 65

ABCR GmbH & CO. KG

Tel: --
Fax: --
Email: info@abcr.de
Country: Germany
ProdList: 6831
Advantage: 75

ACTIVATE SCIENTIFIC GmbH

Tel: --
Fax: --
Email: info@activate-scientific.com
Country: Germany
ProdList: 2856
Advantage: 61

Service Chemical Inc.

Tel: --
Fax: --
Email: sales@chemos-group.com
Country: Germany
ProdList: 6350
Advantage: 71

Merck Schuchardt OHG

Tel: --
Fax: --
Email: schuchardt-vertrieb@merck.de
Country: Germany
ProdList: 5827
Advantage: 74

More

Less

View Lastest Price from 2-Bromothiazole manufacturers

JINING XINHE CHEMICAL CO., LTD

Product: 2-Bromothiazole 3034-53-5
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 10ton
Release date: 2024-07-22

Shaanxi Dideu Medichem Co. Ltd

Product: 2-Bromothiazole 3034-53-5
Price: US $1.00/Kg
Min. Order: 1Kg
Purity: 98%
Supply Ability: 20T
Release date: 2024-07-18

Henan Fengda Chemical Co., Ltd

Product: 2-Bromothiazole 3034-53-5
Price: US $32.00-1.10/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-04-22

3034-53-5, 2-BromothiazoleRelated Search:

2,2'-Dithiobis(benzothiazole) Thiazole Benzothiazole 2-Mercaptobenzothiazole Fosthiazate 3-Bromoanisole Methylchloroisothiazolinone/methylisothiazolinone mixture (MCIT/MIT) 2-(2-Aminothiazol-4-yl)glyoxylic acid 2-BROMOCARBAZOLE 2-Bromonaphthalene 2-Bromo-1,3-benzothiazole 2,4-BROMOTHIAZOLE 2-BROMO-4-CHLOROBENZOTHIAZOLE 2-BROMOTHIAZOLE-5-METHANOL ETHYL 2-BROMO-4-METHYL-1,3-THIAZOLE-5-CARBOXYLATE 2-BROMOTHIAZOLE-4-METHANOL 2-BROMOTHIAZOLE-4-CARBALDEHYDE 2-BROMOTHIAZOLE-5-CARBOXYLIC ACID

2-THIAZOLYL BROMIDE

2-BROMOTHIOAZOLE

2-BROMOTHIAZOLE

2-BROMO-1,3-THIAZOLE

TIMTEC-BB SBB003918

2-Bromothiazole, 98+%

Thiazole, 2-bromo-

2-bromo-thiazol

2-BROMOTHIAZOLE 99+%

2-BroMothiazole, 98+% 25ML

2-BroMothiazole, 98+% 5ML

NSC 91532

2-BROMOTHIAZOLE FOR SYNTHESIS

2 - broMine thiazole

CL028

TZ-Br

N,N'-bis(2,4-dinitrophenyl)ethane-1,2-diamine

2-Bromthiazol

2-Bromothiazole &gt

2-bromothiazole-4,5-d2

3034-53-5

3430-53-5

C3H2BrNS

C3H2SNBr

-SCHCHNCBr

Thiazoles

Halogenated Heterocycles

Heterocyclic Building Blocks

Building Blocks

alkyl bromide

Building Blocks

C3 to C7

Chemical Synthesis

Halogenated Heterocycles

Heterocyclic Building Blocks

Sulfur & Selenium Compounds

Thiazoles, Isothiazoles & Benzothiazoles

Building Blocks

Halogenated Heterocycles

Heterocyclic Building Blocks

Heterocyclic Compounds

Thiazoles

Halides

Heterocycles

ThiazolesHeterocyclic Building Blocks

Thiazoles, Isothiazoles &Benzothiazoles

API intermediates

Organohalides

Thiazole

API