2-Bromothiazole

ChemicalBook > CAS DataBase List > 2-Bromothiazole

Description Referrence

Product Name: 2-Bromothiazole
CAS No.: 3034-53-5
Chemical Name: 2-Bromothiazole
Synonyms: 2-BROMO-1,3-THIAZOLE;CL028;TZ-Br;NSC 91532;2-Bromthiazol;2-bromo-thiazol;2-BROMOTHIAZOLE;2-BROMOTHIOAZOLE;Thiazole, 2-bromo-;2-THIAZOLYL BROMIDE
CBNumber: CB1739860
Molecular Formula: C3H2BrNS
Formula Weight: 164.02
MOL File: 3034-53-5.mol

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2-Bromothiazole Property

Melting point:: 171 C
Boiling point:: 171 °C (lit.)
Density: 1.82 g/mL at 25 °C (lit.)
refractive index: n20/D 1.593(lit.)
Flash point:: 146 °F
storage temp.: 2-8°C
solubility: Chloroform, Dichloromethane
pka: 0.84±0.10(Predicted)
form: Liquid
color: Clear colorless to orange-brown
Specific Gravity: 1.836
Water Solubility: insoluble
BRN: 105724
InChIKey: RXNZFHIEDZEUQM-UHFFFAOYSA-N
CAS DataBase Reference: 3034-53-5(CAS DataBase Reference)
NIST Chemistry Reference: Thiazole, 2-bromo-(3034-53-5)
EPA Substance Registry System: Thiazole, 2-bromo- (3034-53-5)

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Safety

Hazard Codes: Xi,F
Risk Statements: 36/37/38
Safety Statements: 23-24/25-36-26
RIDADR: 1993
WGK Germany: 3
TSCA: Yes
HazardClass: IRRITANT, FLAMMABLE
HS Code: 29341000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H227Combustible liquid

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P403+P235Store in a well-ventilated place. Keep cool.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 160474
Product name: 2-Bromothiazole
Purity: 98%
Packaging: 5g
Price: $54.9
Updated: 2024/03/01

Sigma-Aldrich

Product number: 160474
Product name: 2-Bromothiazole
Purity: 98%
Packaging: 25g
Price: $102
Updated: 2024/03/01

TCI Chemical

Product number: B1280
Product name: 2-Bromothiazole
Purity: >98.0%(GC)
Packaging: 25g
Price: $79
Updated: 2024/03/01

TCI Chemical

Product number: B1280
Product name: 2-Bromothiazole
Purity: >98.0%(GC)
Packaging: 250g
Price: $464
Updated: 2024/03/01

Alfa Aesar

Product number: A14838
Product name: 2-Bromothiazole, 99%
Packaging: 10g
Price: $59.65
Updated: 2024/03/01

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2-Bromothiazole Chemical Properties,Usage,Production

Description

It is usually used as the intermediate or raw material to produce various products in the organic synthesis and pharmaceutical industry, such as 2-acetylthiazole, antibiotics, and anticholinergic drugs. Specifically, this chemical can act as the raw material to produce camalexin through reaction with indolylmagnesium iodide.¹Moreover, this substance has been selected as the reactant to prepare the thiazole Grignard reagents and thiazolyllithium compounds, which can be converted into thiazole-2-carboxylic acid via a halogen-metal exchange reaction.^{2, 3} In addition, 2-bromothiazole has been used to synthesize N-aryl aminothiazoles, which are found to function as the inhibitors of cyclin-dependent kinases.⁴Besides, this compound may be involved in the synthesis of ethynylthiazoles that exhibits a desirable anti-inflammatory activity.⁵

Referrence

Ayer, W. A.; Craw, P. A.; Ma, Y. T.; Miao, S. C., SYNTHESIS OF CAMALEXIN AND RELATED PHYTOALEXINS. Tetrahedron 1992, 48, 2919-2924.
Kurkjy, R. P.; Brown, E. V., THE PREPARATION OF THIAZOLE GRIGNARD REAGENTS AND THIAZOLYLLITHIUM COMPOUNDS. J. Am. Chem. Soc. 1952, 74, 6260-6262.
Beyerman, H. C.; Berben, P. H.; Bontekoe, J. S., THE SYNTHESIS OF THIAZOLE-2-CARBOXYLIC AND OF THIAZOLE-5-CARBOXYLIC ACID VIA A HALOGEN-METAL EXCHANGE REACTION. Recl. Trav. Chim. Pays-Bas-J. Roy. Neth. Chem. Soc. 1954, 73, 325-332.
Misra, R. N.; Xiao, H. Y.; Williams, D. K.; Kim, K. S.; Lu, S. F.; Keller, K. A.; Mulheron, J. G.; Batorsky, R.; Tokarski, J. S.; Sack, J. S.; Kimball, D.; Lee, F. Y.; Webster, K. R., Synthesis and biological activity of N-aryl-2-aminothiazoles: potent pan inhibitors of cyclin-dependent kinases. Bioorg. Med. Chem. Lett. 2004, 14, 2973-2977.
Geronikaki, A.; Vasilevsky, S.; Hadjipavlou-Litina, D.; Lagunin, A.; Poroikov, B. V., Synthesis and anti-inflammatory activity of ethynylthiazoles. Khim. Geterotsiklicheskikh Soedin. 2006, 769-774.

Chemical Properties

Colourless Liquid

Uses

Aryl halide used to N-arylate 5- and 7-azaindoles.1 Copper-catalyzed cyanation provides 2-cyanothiazole.2

Uses

2-Bromothiazole, is intended used for research purpose only. It is also used as Aryl halide which are used to N-arylate 5- and 7-azaindoles. Copper-catalyzed cyanation provides 2-cyanothiazole

Uses

2-Bromothiazole is a heterocyclic S compound to induce base-pair substitution and having mutagenic activity.

2-Bromothiazole Preparation Products And Raw materials

Raw materials

Phosphoric acid Nitric acid

Preparation Products

THIAZOLE-2-CARBOXYLIC ACID 2-Bromo-5-fomylthiazole 1,3-Thiazole-2-carbonyl chloride Thiazole-5-carboxylic acid 5-Bromothiazole

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View Lastest Price from 2-Bromothiazole manufacturers

Henan Fengda Chemical Co., Ltd

Product: 2-Bromothiazole 3034-53-5
Price: US $32.00-1.10/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-04-22

Hebei Duling International Trade Co. LTD

Product: 2-Bromothiazole 3034-53-5
Price: US $50.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 50 tons
Release date: 2023-04-19

Henan Aochuang Chemical Co.,Ltd.

Product: 2-Bromothiazole 3034-53-5
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1ton
Release date: 2022-10-10

3034-53-5, 2-BromothiazoleRelated Search:

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2-THIAZOLYL BROMIDE

2-BROMOTHIOAZOLE

2-BROMOTHIAZOLE

2-BROMO-1,3-THIAZOLE

TIMTEC-BB SBB003918

2-Bromothiazole, 98+%

Thiazole, 2-bromo-

2-bromo-thiazol

2-BROMOTHIAZOLE 99+%

2-BroMothiazole, 98+% 25ML

2-BroMothiazole, 98+% 5ML

NSC 91532

2-BROMOTHIAZOLE FOR SYNTHESIS

2 - broMine thiazole

CL028

TZ-Br

N,N'-bis(2,4-dinitrophenyl)ethane-1,2-diamine

2-Bromthiazol

2-Bromothiazole &gt

2-bromothiazole-4,5-d2

3034-53-5

3430-53-5

C3H2BrNS

C3H2SNBr

-SCHCHNCBr

Thiazoles

Halogenated Heterocycles

Heterocyclic Building Blocks

Building Blocks

alkyl bromide

Building Blocks

C3 to C7

Chemical Synthesis

Halogenated Heterocycles

Heterocyclic Building Blocks

Sulfur & Selenium Compounds

Thiazoles, Isothiazoles & Benzothiazoles

Building Blocks

Halogenated Heterocycles

Heterocyclic Building Blocks

Heterocyclic Compounds

Thiazoles

Halides

Heterocycles

ThiazolesHeterocyclic Building Blocks

Thiazoles, Isothiazoles &Benzothiazoles

API intermediates

Organohalides

Thiazole

API